Results 31 to 40 of about 12,064 (247)

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy [PDF]

, 2014
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post-partum haemorrhage.
Dale, T, Nan Lin, Brown, Pamela, England, Sarah, Pamela Brown, Jeff Jerman, McCavera, Samantha, Rand, DA, Tickle, D, Kettleborough, Catherine, McCavera, S, Brosens, Jan, Taggart, MJ, Chan, YW, Trezise, Derek J., Catherine Kettleborough, Manu Vatish, Denton, JS, Jerod S Denton, van den Berg, HA, Siobhan Quenby, Atia, Jolene, Cara Rada, England, Sarah K, Rada, C, Rada, Cara, Rand, David A., Shmygol, A, Catalano, R, Vatish, M, Brown, P, van den Berg, Hugo A., Dale, Timothy, David A Rand, Michael J Taggart, Kettleborough, C, McCloskey, C., Lin, Nan, McCloskey, C, Bailey, Elizabeth H., Chan, Yi-Wah, Vatish, Manu, Jerman, J, Andrew M Blanks, Sarah K England, Tickle, David, Berg, Hugo van den, Kanumilli, S, Shmygol, Anatoly, England, Sarah K., Quenby, S, Chan, Y-W, Srinivasan Kanumilli, Steve Thornton, Conor McCloskey, Timothy Dale, Zhang, J, Kanumilli, Srinivasan, David Tickle, Catalano, Roberto D., Atia, J, Yi‐Wah Chan, Jan J Brosens, England, S., Trezise, Derek, Paul Wright, Trezise, DJ, Jie Zhang, Roberto Catalano, Quenby, Siobhan, Bailey, Elizabeth, Derek J Trezise, Brosens, Jan J., McCloskey, Conor, Jerman, Jeff, England, SK, Denton, Jerod S., Zhang, Jie, Brosens, JJ, et al,, Wright, P, Thornton, S, Thornton, Steven, Hugo A van den Berg, Jolene Atia, Taggart, Michael J., Blanks, Andrew M., van den Berg, H. A., Thornton, Steve, Catalano, Roberto, Blanks, AM, Samantha McCavera, Rand, D. A., Blanks, Andrew, Denton, Jerod, Lin, N, Taggart, Michael, Wright, Paul, Bailey, E, Elizabeth Bailey, Anatoly Shmygol   +100 more
core   +1 more source

The therapeutic agents that target ATP-sensitive potassium channels

Acta Pharmaceutica, 2016
ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
doaj   +1 more source

Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines

BMC Cancer, 2005
Background Previous data from our laboratory has indicated that there is a functional link between the β-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to
Schuller Hildegard M, Cekanova Maria, Dhar Madhu S, Plummer Howard K   +3 more
doaj   +1 more source

Subunit gating resulting from individual protonation events in Kir2 channels

Nature Communications, 2023
Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore.
Grigory Maksaev, Michael Bründl-Jirout, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl, Sun-Joo Lee, Colin G. Nichols   +5 more
doaj   +1 more source

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes

, 2010
An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone ...
Muriel Nobles, Sonia Sebastian, Tinker, A., Andrew Tinker, Nobles, M., Sebastian, S., Nobles, Muriel   +6 more
core   +1 more source

Association Between KCNJ6 (GIRK2) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence

Journal of Pharmacological Sciences, 2014
.: G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several Gi/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of ...
Daisuke Nishizawa, Ken-ichi Fukuda, Shinya Kasai, Yasukazu Ogai, Junko Hasegawa, Naomi Sato, Hidetaka Yamada, Fumihiko Tanioka, Haruhiko Sugimura, Masakazu Hayashida, Kazutaka Ikeda   +10 more
doaj   +1 more source

Permeation and Gating of an Inwardly Rectifying Potassium Channel [PDF]

The Journal of General Physiology, 1998
Permeation, gating, and their interrelationship in an inwardly rectifying potassium (K+) channel, ROMK2, were studied using heterologous expression in Xenopus oocytes. Patch-clamp recordings of single channels were obtained in the cell-attached mode. The gating kinetics of ROMK2 were well described by a model having one open and two closed states.
Han Choe, Henry Sackin, Lawrence G. Palmer   +2 more
openaire   +1 more source

Involvement of Inwardly Rectifying Potassium (Kir) Channels in the Toxicity of Flonicamid to Drosophila melanogaster

Insects
Inwardly rectifying potassium (Kir) channels regulate essential physiological processes in insects and have been identified as potential targets for developing new insecticides.
Xuan Liu, Yuying Gao, Tengfei Liu, Hailiang Guo, Jizu Qiao, Jianya Su   +5 more
doaj   +1 more source

Voltage‐gated and inwardly rectifying potassium channels [PDF]

The Journal of Physiology, 1997
This lecture is dedicated to Max Delbrück and Seymour Benzer. Max Delbrück was our graduate advisor. He introduced us to a variety of biophysical problems, and taught us ways of thinking about these problems by example. Potassium channels was one of the topics included in his journal club in the early seventies; Max also carefully considered the ...
Lily Yeh Jan, Yuh Nung Jan
openaire   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source