Results 31 to 40 of about 19,097 (250)
Polyamine Block of Inwardly Rectifying Potassium Channels [PDF]
, 2011 Polyamine blockade of inwardly rectifying potassium (Kir) channels underlies their steep voltage--dependence observed in native cells. The structural determinants of polyamine blockade and the structure-activity profile of endogenous polyamines requires specialized methodology for characterizing polyamine interactions with Kir channels.
Harley T, Kurata +2 more
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The therapeutic agents that target ATP-sensitive potassium channels
Acta Pharmaceutica, 2016 ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
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Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines
BMC Cancer, 2005 Background Previous data from our laboratory has indicated that there is a functional link between the β-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to
Schuller Hildegard M +3 more
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Subunit gating resulting from individual protonation events in Kir2 channels
Nature Communications, 2023 Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore.
Grigory Maksaev +5 more
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Frontiers in Cell and Developmental Biology, 2022 Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders.
Natalie A. Hager +3 more
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Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes [PDF]
, 1993 Injection of rat atrial RNA into Xenopus oocytes resulted in the expression of a guanine nucleotide binding (G) protein-activated K+ channel. Current through the channel could be activated by acetylcholine or, if RNA encoding a neuronal 5HT1A receptor ...
Dascal, Nathan +5 more
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Genetic mapping of natural variation in potassium concentrations in shoots of Arabidopsis thaliana [PDF]
, 2006 Naturally-occurring variation in K+ concentrations between plant genotypes is potentially exploitable in a number of ways, including altering the relationship between K+ accumulation and growth, enhancing salinity resistance, or improving forage quality.
Harada, H., Leigh, R.
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Voltage‐gated and inwardly rectifying potassium channels [PDF]
The Journal of Physiology, 1997 This lecture is dedicated to Max Delbrück and Seymour Benzer. Max Delbrück was our graduate advisor. He introduced us to a variety of biophysical problems, and taught us ways of thinking about these problems by example. Potassium channels was one of the topics included in his journal club in the early seventies; Max also carefully considered the ...
Lily Yeh Jan, Yuh Nung Jan
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Journal of Pharmacological Sciences, 2014 .: G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several Gi/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of ...
Daisuke Nishizawa +10 more
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Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels [PDF]
The Journal of Physiology, 2006 Recent studies have shown that Kir2 channels display differential sensitivity to intracellular polyamines, and have raised a number of questions about several properties of inward rectification important to the understanding of their physiological roles.
Panama, Brian K., Lopatin, Anatoli N.
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