Results 51 to 60 of about 19,097 (250)

Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

Genes and Diseases, 2021
Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by KCNJ16) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by
Junhui Zhang, Jian Han, Lingfei Li, Qiong Zhang, Yanhai Feng, Youzhao Jiang, Fang Deng, Yuping Zhang, Qinan Wu, Bing Chen, Jiongyu Hu   +10 more
doaj   +1 more source

Revisit of the Cardiac Inward Rectifier Potassium Current IK1 [PDF]

, 2010
Inward rectifier potassium currents are present in different types of cells. In the heart, the inward rectifier potassium current IK1 plays a crucial role in maintaining cardiac resting membrane potential and excitability. It is generally believed that
Dong, MQ, Li, GR
core   +1 more source

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues

Advanced Science, EarlyView.
Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak, Ashley D. Westerfield, Vardhman Kumar, Kasturi Chakraborty, Navaneeth Krishna Rajeeva Pandian, Christopher S. Chen, Sangeeta N. Bhatia   +6 more
wiley   +1 more source

Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. [PDF]

, 1998
A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two
Goldstein, SA, Ilan, N, Pausch, MH, Wang, KW   +3 more
core  

Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade [PDF]

, 2012
Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially anti-arrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K+ currents.
A Alday, A Maguy, AA Dawodu, AEG Raine, AJ Camm, AJ Workman, AJ Workman, AJ Workman, AJ Workman, AJ Workman, Andrew C. Rankin, Antony J. Workman, B Fermini, CA Karle, CJ Redpath, D Dobrev, D Escande, F Cao, F Lesage, G Bru-Mercier, Gillian E. Marshall, GR Li, J Lopez-Sendon, James O. Tellez, JL Greenstein, JM Nerbonne, JM Nerbonne, John Dempster, Julie A. Russell, Kathleen A. Kane, M Courtemanche, M Courtemanche, M Fink, M Greiser, Mark R. Boyett, N Gaborit, N Niwa, Pardeep S. Jhund, QY Liu, RP Xiao, S Koumi, S Nattel, Susan Currie, SV Pandit, T Christ, U Schotten, W Kong   +46 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Contribution of glial inwardly rectifying potassium (Kir) channels to potassium buffering in insect neural systems

iScience
Summary: There is a paucity of information pertaining to the fundamental roles of glia in insect central nervous system (CNS) function and in the maintenance of ionic gradients. Inward rectifier potassium (Kir) channels are known to drive K+ buffering in
Rui Chen, Zhilin Li, Alyssa Johnson, Daniel R. Swale   +3 more
doaj   +1 more source

Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol

Scientific Reports, 2017
Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron’s membrane potential, providing an important component of inhibition in the brain.
Ian W. Glaaser, Paul A. Slesinger
doaj   +1 more source

Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines

BMC Cancer, 2004
Background Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways.
Cakir Yavuz, Yu Qiang, Plummer Howard K, Schuller Hildegard M   +3 more
doaj   +1 more source

Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination [PDF]

, 2001
To understand the cellular and in vivo functions of specific K^+ channels in glia, we have studied mice with a null mutation in the weakly inwardly rectifying K^+ channel subunit Kir4.1.
Jacobs, Russell E., Kofuji, Paulo, Lester, Henry A., Neusch, Clemens, Rozengurt, Nora   +4 more
core   +1 more source