Results 51 to 60 of about 12,064 (247)

Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila

Nature Communications, 2023
A neuron’s regenerative capacity is governed by its intrinsic and extrinsic environment. Both peripheral and central neurons exhibit cell-type-dependent axon regeneration, but the underlying mechanism is unclear.
Shannon Trombley, Jackson Powell, Pavithran Guttipatti, Andrew Matamoros, Xiaohui Lin, Tristan O’Harrow, Tobias Steinschaden, Leann Miles, Qin Wang, Shuchao Wang, Jingyun Qiu, Qingyang Li, Feng Li, Yuanquan Song   +13 more
doaj   +1 more source

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

iScience, 2021
Summary: Mutations in the GNB1 gene, encoding the Gβ1 subunit of heterotrimeric G proteins, cause GNB1 Encephalopathy. Patients experience seizures, pointing to abnormal activity of ion channels or neurotransmitter receptors.
Haritha P. Reddy, Daniel Yakubovich, Tal Keren-Raifman, Galit Tabak, Vladimir A. Tsemakhovich, Maria H. Pedersen, Boris Shalomov, Sophie Colombo, David B. Goldstein, Jonathan A. Javitch, Amal K. Bera, Nathan Dascal   +11 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Identification of putative potassium channel homologues in pathogenic protozoa [PDF]

, 2012
K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L, Neil V Marrion, Marrion, NV, David L Prole   +3 more
core   +1 more source

G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury [PDF]

, 2020
Background: G protein-gated inwardly rectifying potassium (GIRK) channels are involved in the regulation of neuronal excitability. Four GIRK subunits (GIRK1-4) are expressed in rat dorsal root ganglia (DRGs).
Mulder, J,, Lyu, Chuang, Lyu, Gong-Wei, Martinez, A, Shi, Tie-Jun, Lyu, C, Lyu, G-W, Shi, T-JS, Mulder, Jan, Martinez, Aurora   +9 more
core   +1 more source

Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

Genes and Diseases, 2021
Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by KCNJ16) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by
Junhui Zhang, Jian Han, Lingfei Li, Qiong Zhang, Yanhai Feng, Youzhao Jiang, Fang Deng, Yuping Zhang, Qinan Wu, Bing Chen, Jiongyu Hu   +10 more
doaj   +1 more source

Inwardly Rectifying Potassium Channels: Their Molecular Heterogeneity and Function.

The Japanese Journal of Physiology, 1997
A variety of cells including cardiac myocytes and neuronal cells possess inwardly rectifying K+ (Kir) channels through which currents flow more readily in the inward direction than outward. These K+ channels play pivotal roles in maintenance of the resting membrane potential, in regulation of the action potential duration, in receptor-dependent ...
ISOMOTO, Shojiro, KONDO, Chikako, KURACHI, Yoshihisa   +2 more
openaire   +3 more sources

Unconventional voltage sensing in an inwardly rectifying potassium channel

Journal of General Physiology, 2021
Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with ...
openaire   +2 more sources

Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels [PDF]

The Journal of Physiology, 2006
Recent studies have shown that Kir2 channels display differential sensitivity to intracellular polyamines, and have raised a number of questions about several properties of inward rectification important to the understanding of their physiological roles.
Panama, Brian K., Lopatin, Anatoli N.
openaire   +3 more sources

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
wiley   +1 more source