Results 51 to 60 of about 1,076,274 (226)

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila

Nature Communications, 2023
A neuron’s regenerative capacity is governed by its intrinsic and extrinsic environment. Both peripheral and central neurons exhibit cell-type-dependent axon regeneration, but the underlying mechanism is unclear.
Shannon Trombley, Jackson Powell, Pavithran Guttipatti, Andrew Matamoros, Xiaohui Lin, Tristan O’Harrow, Tobias Steinschaden, Leann Miles, Qin Wang, Shuchao Wang, Jingyun Qiu, Qingyang Li, Feng Li, Yuanquan Song   +13 more
doaj   +1 more source

Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

Genes and Diseases, 2021
Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by KCNJ16) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by
Junhui Zhang, Jian Han, Lingfei Li, Qiong Zhang, Yanhai Feng, Youzhao Jiang, Fang Deng, Yuping Zhang, Qinan Wu, Bing Chen, Jiongyu Hu   +10 more
doaj   +1 more source

Unconventional voltage sensing in an inwardly rectifying potassium channel

Journal of General Physiology, 2021
Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with ...
openaire   +2 more sources

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Contribution of glial inwardly rectifying potassium (Kir) channels to potassium buffering in insect neural systems

iScience
Summary: There is a paucity of information pertaining to the fundamental roles of glia in insect central nervous system (CNS) function and in the maintenance of ionic gradients. Inward rectifier potassium (Kir) channels are known to drive K+ buffering in
Rui Chen, Zhilin Li, Alyssa Johnson, Daniel R. Swale   +3 more
doaj   +1 more source

Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol

Scientific Reports, 2017
Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron’s membrane potential, providing an important component of inhibition in the brain.
Ian W. Glaaser, Paul A. Slesinger
doaj   +1 more source

Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines

BMC Cancer, 2004
Background Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways.
Cakir Yavuz, Yu Qiang, Plummer Howard K, Schuller Hildegard M   +3 more
doaj   +1 more source

Inwardly Rectifying Potassium Channels: Their Molecular Heterogeneity and Function.

The Japanese Journal of Physiology, 1997
A variety of cells including cardiac myocytes and neuronal cells possess inwardly rectifying K+ (Kir) channels through which currents flow more readily in the inward direction than outward. These K+ channels play pivotal roles in maintenance of the resting membrane potential, in regulation of the action potential duration, in receptor-dependent ...
ISOMOTO, Shojiro, KONDO, Chikako, KURACHI, Yoshihisa   +2 more
openaire   +3 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source