Results 41 to 50 of about 11,215 (198)
Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels
iScience, 2021 Summary: Mutations in the GNB1 gene, encoding the Gβ1 subunit of heterotrimeric G proteins, cause GNB1 Encephalopathy. Patients experience seizures, pointing to abnormal activity of ion channels or neurotransmitter receptors.
Haritha P. Reddy +11 more
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Inwardly Rectifying Potassium Channels: Their Molecular Heterogeneity and Function.
The Japanese Journal of Physiology, 1997 A variety of cells including cardiac myocytes and neuronal cells possess inwardly rectifying K+ (Kir) channels through which currents flow more readily in the inward direction than outward. These K+ channels play pivotal roles in maintenance of the resting membrane potential, in regulation of the action potential duration, in receptor-dependent ...
ISOMOTO, Shojiro +2 more
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Unconventional voltage sensing in an inwardly rectifying potassium channel
Journal of General Physiology, 2021 Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with ...
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Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
iScienceSummary: There is a paucity of information pertaining to the fundamental roles of glia in insect central nervous system (CNS) function and in the maintenance of ionic gradients. Inward rectifier potassium (Kir) channels are known to drive K+ buffering in
Rui Chen +3 more
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Scientific Reports, 2017 Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron’s membrane potential, providing an important component of inhibition in the brain.
Ian W. Glaaser, Paul A. Slesinger
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BMC Cancer, 2004 Background Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways.
Cakir Yavuz +3 more
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Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases
Genes and Diseases, 2021 Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by KCNJ16) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by
Junhui Zhang +10 more
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Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels [PDF]
The Journal of Physiology, 2006 Recent studies have shown that Kir2 channels display differential sensitivity to intracellular polyamines, and have raised a number of questions about several properties of inward rectification important to the understanding of their physiological roles.
Panama, Brian K., Lopatin, Anatoli N.
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Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity
Cellular and Molecular Life Sciences, 2022 AbstractPolymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a dose-limiting factor of paramount importance and can lead to suboptimal treatment. To elucidate the mechanism and develop effective strategies to overcome polymyxin toxicity, we employed ...
Jing Lu +16 more
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