Results 21 to 30 of about 12,064 (247)
INWARD RECTIFIERS AND THEIR REGULATION BY ENDOGENOUS POLYAMINES
Frontiers in Physiology, 2014 Inwardly-rectifying potassium (Kir) channels contribute to maintenance of the resting membrane potential and regulation of electrical excitation in many cell types.
Victoria A Baronas +1 more
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Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Cell Reports, 2021 Summary: G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with ...
Yamuna Kalyani Mathiharan +5 more
doaj +1 more source
Why do platelets express K+ channels?
Platelets, 2021 Potassium ions have widespread roles in cellular homeostasis and activation as a consequence of their large outward concentration gradient across the surface membrane and ability to rapidly move through K+-selective ion channels.
Joy R Wright, Martyn P. Mahaut-Smith
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Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro [PDF]
, 1989 The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular
Ten Bruggencate, Gerrit +2 more
core +1 more source
Nature Communications, 2019 Opening of G protein-gated inwardly rectifying potassium channels (GIRK) is coupled to the activation of a GPCR. Here the authors use NMR and cell-based BRET assays to gain insights into the mechanisms underlying family-specific activation and find that ...
Hanaho Kano +7 more
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Reciprocal modulation of IK1-INa extends excitability in cardiac ventricular cells
Frontiers in Physiology, 2016 The inwardly rectifying potassium current (IK1) and the fast inward sodium current (INa) are reciprocally modulated in mammalian ventricular myocytes.
Anthony Varghese
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Frontiers in Genetics, 2019 Inwardly rectifying K+ channel 4.1 (Kir4.1), encoded by KCNJ10, is a member of the inwardly rectifying potassium channel family. In the brain, Kir4.1 is predominant in astrocytic glia and accounts for the spatial buffering of K+ released by neurons ...
Hongfeng Zhang +14 more
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Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels [PDF]
Cell, 1996 Inwardly rectifying potassium channels have an important role in determining the resting potential of the cell. They are tetrameric proteins with two transmembrane segments (M1 and M2), a pore-forming loop (H5), a cytoplasmic N-terminal, and longer C-terminal domain. We have used biochemical and electrophysiological methods to identify regions required
Tinker, Andrew +2 more
openaire +2 more sources
Self-organized enhancement of conductivity in biological ion channels [PDF]
, 2013 We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Kaufman, Igor +9 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders.
Natalie A. Hager +3 more
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