Results 21 to 30 of about 11,215 (198)
Reciprocal modulation of IK1-INa extends excitability in cardiac ventricular cells
Frontiers in Physiology, 2016 The inwardly rectifying potassium current (IK1) and the fast inward sodium current (INa) are reciprocally modulated in mammalian ventricular myocytes.
Anthony Varghese
doaj +1 more source
Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels [PDF]
Cell, 1996 Inwardly rectifying potassium channels have an important role in determining the resting potential of the cell. They are tetrameric proteins with two transmembrane segments (M1 and M2), a pore-forming loop (H5), a cytoplasmic N-terminal, and longer C-terminal domain. We have used biochemical and electrophysiological methods to identify regions required
Tinker, Andrew +2 more
openaire +2 more sources
Frontiers in Genetics, 2019 Inwardly rectifying K+ channel 4.1 (Kir4.1), encoded by KCNJ10, is a member of the inwardly rectifying potassium channel family. In the brain, Kir4.1 is predominant in astrocytic glia and accounts for the spatial buffering of K+ released by neurons ...
Hongfeng Zhang +14 more
doaj +1 more source
The therapeutic agents that target ATP-sensitive potassium channels
Acta Pharmaceutica, 2016 ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
doaj +1 more source
Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines
BMC Cancer, 2005 Background Previous data from our laboratory has indicated that there is a functional link between the β-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to
Schuller Hildegard M +3 more
doaj +1 more source
Subunit gating resulting from individual protonation events in Kir2 channels
Nature Communications, 2023 Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore.
Grigory Maksaev +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders.
Natalie A. Hager +3 more
doaj +1 more source
Journal of Pharmacological Sciences, 2014 .: G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several Gi/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of ...
Daisuke Nishizawa +10 more
doaj +1 more source
Permeation and Gating of an Inwardly Rectifying Potassium Channel [PDF]
The Journal of General Physiology, 1998 Permeation, gating, and their interrelationship in an inwardly rectifying potassium (K+) channel, ROMK2, were studied using heterologous expression in Xenopus oocytes. Patch-clamp recordings of single channels were obtained in the cell-attached mode. The gating kinetics of ROMK2 were well described by a model having one open and two closed states.
Han Choe +2 more
openaire +1 more source
InsectsInwardly rectifying potassium (Kir) channels regulate essential physiological processes in insects and have been identified as potential targets for developing new insecticides.
Xuan Liu +5 more
doaj +1 more source