Results 11 to 20 of about 12,064 (247)

Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics

Frontiers in Physiology, 2014
Alcohol (ethanol)-induced behaviors arise from direct interaction of alcohol with discrete protein cavities within brain proteins. Recent structural and biochemical studies have provided new insights into the mechanism of alcohol-dependent activation of ...
Karthik eBodhinathan, Paul A Slesinger
doaj   +2 more sources

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity

Cellular and Molecular Life Sciences, 2022
AbstractPolymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a dose-limiting factor of paramount importance and can lead to suboptimal treatment. To elucidate the mechanism and develop effective strategies to overcome polymyxin toxicity, we employed ...
Jing Lu, Mohammad A. K. Azad, Julie L. M. Moreau, Yan Zhu, Xukai Jiang, Mary Tonta, Rachel Lam, Hasini Wickremasinghe, Jinxin Zhao, Jiping Wang, Harold A. Coleman, Luke E. Formosa, Tony Velkov, Helena C. Parkington, Alexander N. Combes, Joseph Rosenbluh, Jian Li   +16 more
openaire   +4 more sources

Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol

Scientific Reports, 2017
Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron’s membrane potential, providing an important component of inhibition in the brain.
Ian W. Glaaser, Paul A. Slesinger
doaj   +2 more sources

Cloning, functional expression, and pharmacological characterization of inwardly rectifying potassium channels (Kir) from Apis mellifera

Scientific Reports
Potassium channels belong to the super family of ion channels and play a fundamental role in cell excitability. Kir channels are potassium channels with an inwardly rectifying property.
Fabien Sourisseau, Chaimaa Chahine, Valérie Pouliot, Thierry Cens, Pierre Charnet, Mohamed Chahine   +5 more
doaj   +2 more sources

Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. [PDF]

PLoS ONE, 2013
G protein-gated inwardly rectifying potassium (GIRK) channels play an important role in regulating neuronal excitability. Sorting nexin 27b (SNX27b), which reduces surface expression of GIRK channels through a PDZ domain interaction, contains a putative ...
Bartosz Balana, Laia Bahima, Karthik Bodhinathan, Jaume J Taura, Natalie M Taylor, Margaret Y Nettleton, Francisco Ciruela, Paul A Slesinger   +7 more
doaj   +1 more source

Perisynaptic astrocytes as a potential target for novel antidepressant drugs

Journal of Pharmacological Sciences, 2021
Emerging evidence suggests that dysfunctions in glutamatergic signaling are associated with the pathophysiology of depression. Several molecules that act on glutamate binding sites, so-called glutamatergic modulators, are rapid-acting antidepressants ...
Marcos E. Frizzo, Yukihiro Ohno
doaj   +1 more source

Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.

PLoS ONE, 2015
G protein-activated inwardly rectifying potassium (GIRK) channels in 5-HT neurons are assumed to be principal effectors of 5-hydroxytryptamine 1A (5-HT1A) autoreceptors, but their pharmacology, subunit composition and the role in regulation of 5-HT ...
Alberto Montalbano, Renato Corradetti, Boris Mlinar   +2 more
doaj   +1 more source

Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB1 receptors

Journal of Pharmacological Sciences, 2022
Neuropathic pain is refractory to opioid analgesics. Since there are functional linkages between μ-opioid receptors (MOR) and cannabinoid receptors (CBR), the present study was designed to investigate the interactions between MOR and CB1R based on ...
Yoshinori Takemura, Yuka Sudo, Tomoya Saeki, Shinji Kurata, Tsutomu Suzuki, Tomohisa Mori, Yasuhito Uezono   +6 more
doaj   +1 more source

Polyamine Block of Inwardly Rectifying Potassium Channels [PDF]

, 2011
Polyamine blockade of inwardly rectifying potassium (Kir) channels underlies their steep voltage--dependence observed in native cells. The structural determinants of polyamine blockade and the structure-activity profile of endogenous polyamines requires specialized methodology for characterizing polyamine interactions with Kir channels.
Harley T, Kurata, Wayland W L, Cheng, Colin G, Nichols   +2 more
openaire   +2 more sources

CO2-dependent opening of an inwardly rectifying K+ channel [PDF]

, 2011
CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Dale, Nicholas, Robert T. R. Huckstepp, Huckstepp, Robert T. R., Nicholas Dale   +3 more
core   +1 more source