Results 11 to 20 of about 1,076,274 (226)

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity

Cellular and Molecular Life Sciences, 2022
AbstractPolymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a dose-limiting factor of paramount importance and can lead to suboptimal treatment. To elucidate the mechanism and develop effective strategies to overcome polymyxin toxicity, we employed ...
Jing Lu, Mohammad A. K. Azad, Julie L. M. Moreau, Yan Zhu, Xukai Jiang, Mary Tonta, Rachel Lam, Hasini Wickremasinghe, Jinxin Zhao, Jiping Wang, Harold A. Coleman, Luke E. Formosa, Tony Velkov, Helena C. Parkington, Alexander N. Combes, Joseph Rosenbluh, Jian Li   +16 more
openaire   +4 more sources

Structure and function of potassium and calcium channels [PDF]

, 2005
In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage
Stevens, Louisa Rebecca
core   +7 more sources

Multi-omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells. [PDF]

Exp Physiol
Abstract Balance and gaze rely on the rapid and accurate detection and signalling of head movements by vestibular type I and type II hair cells. Signal transduction and transmission involve several types of ion channels, which are acquired progressively during hair cell differentiation and whose identity is known only in part.
Cheli G, Giunta R, Stella F, Guidi E, Laforenza U, Polimeni M, Russo G, Borgo F, Dejan L, Masetto S.   +9 more
europepmc   +2 more sources

Self-organized enhancement of conductivity in biological ion channels [PDF]

, 2013
We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Kaufman, Igor, Khovanov, I. A., Khovanov, Igor A., McClintock, P. V. E., Eisenberg, Robert S., Luchinsky, Dmittri G., McClintock, Peter V. E., Eisenberg, R. S., Luchinsky, Dmitrii G., Tindjong, Rodrigue   +9 more
core   +6 more sources

Pain relief but respiratory depression: Insights into the dark side of opioid overuse. [PDF]

J Physiol
The Journal of Physiology, Volume 604, Issue 17, Page 7017-7018, 1 September 2026.
Zoccal DB.
europepmc   +2 more sources

BRET-Based Approaches for Ion Channels: Emerging Applications and Future Directions. [PDF]

Arch Pharm (Weinheim)
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Kock N, Heitzer L, Massa J, Taterra M, Bermúdez M, Koch O, Schiedel M.   +6 more
europepmc   +2 more sources

Perisynaptic astrocytes as a potential target for novel antidepressant drugs

Journal of Pharmacological Sciences, 2021
Emerging evidence suggests that dysfunctions in glutamatergic signaling are associated with the pathophysiology of depression. Several molecules that act on glutamate binding sites, so-called glutamatergic modulators, are rapid-acting antidepressants ...
Marcos E. Frizzo, Yukihiro Ohno
doaj   +1 more source

Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.

PLoS ONE, 2015
G protein-activated inwardly rectifying potassium (GIRK) channels in 5-HT neurons are assumed to be principal effectors of 5-hydroxytryptamine 1A (5-HT1A) autoreceptors, but their pharmacology, subunit composition and the role in regulation of 5-HT ...
Alberto Montalbano, Renato Corradetti, Boris Mlinar   +2 more
doaj   +1 more source

Polyamine Block of Inwardly Rectifying Potassium Channels [PDF]

, 2011
Polyamine blockade of inwardly rectifying potassium (Kir) channels underlies their steep voltage--dependence observed in native cells. The structural determinants of polyamine blockade and the structure-activity profile of endogenous polyamines requires specialized methodology for characterizing polyamine interactions with Kir channels.
Harley T, Kurata, Wayland W L, Cheng, Colin G, Nichols   +2 more
openaire   +2 more sources

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes [PDF]

, 2010
An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone ...
Muriel Nobles, Sonia Sebastian, Tinker, A., Andrew Tinker, Nobles, M., Sebastian, S., Nobles, Muriel   +6 more
core   +1 more source