Results 61 to 70 of about 1,076,274 (226)

Recent advances in the pathogenesis and drug actions in periodic paralyses and related channelophaties

Frontiers in Pharmacology, 2011
The periodic paralysis(PP) are rare autosomal-dominant disorders associated to mutations in the skeletal muscle sodium, calcium and potassium channel genes characterized by muscle fiber depolarization with un-excitability, episodes of weakness with ...
Domenico eTricarico, Diana eConte Camerino   +1 more
doaj   +1 more source

Determination of the subunit stoichiometry of an inwardly rectifying potassium channel

Neuron, 1995
Inwardly rectifying K+ channels are distantly related to their voltage-gated counterparts and possess a structural motif of only two putative transmembrane segments in each subunit. They are formed by the assembly of an unknown number of subunits. We have examined the subunit stoichiometry of a strongly rectifying K+ channel, IRK1, by linking together ...
Yang, Jian, Jan, Yuh Nung, Jan, Lily Yeh
openaire   +2 more sources

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV, Giblin, JP, Clapp, LH, Tinker, A, Cui, Y   +4 more
core  

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy [PDF]

, 2014
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post-partum haemorrhage.
Dale, T, Nan Lin, Brown, Pamela, England, Sarah, Pamela Brown, Jeff Jerman, McCavera, Samantha, Rand, DA, Tickle, D, Kettleborough, Catherine, McCavera, S, Brosens, Jan, Taggart, MJ, Chan, YW, Trezise, Derek J., Catherine Kettleborough, Manu Vatish, Denton, JS, Jerod S Denton, van den Berg, HA, Siobhan Quenby, Atia, Jolene, Cara Rada, England, Sarah K, Rada, C, Rada, Cara, Rand, David A., Shmygol, A, Catalano, R, Vatish, M, Brown, P, van den Berg, Hugo A., Dale, Timothy, David A Rand, Michael J Taggart, Kettleborough, C, McCloskey, C., Lin, Nan, McCloskey, C, Bailey, Elizabeth H., Chan, Yi-Wah, Vatish, Manu, Jerman, J, Andrew M Blanks, Sarah K England, Tickle, David, Berg, Hugo van den, Kanumilli, S, Shmygol, Anatoly, England, Sarah K., Quenby, S, Chan, Y-W, Srinivasan Kanumilli, Steve Thornton, Conor McCloskey, Timothy Dale, Zhang, J, Kanumilli, Srinivasan, David Tickle, Catalano, Roberto D., Atia, J, Yi‐Wah Chan, Jan J Brosens, England, S., Trezise, Derek, Paul Wright, Trezise, DJ, Jie Zhang, Roberto Catalano, Quenby, Siobhan, Bailey, Elizabeth, Derek J Trezise, Brosens, Jan J., McCloskey, Conor, Jerman, Jeff, England, SK, Denton, Jerod S., Zhang, Jie, Brosens, JJ, et al,, Wright, P, Thornton, S, Thornton, Steven, Hugo A van den Berg, Jolene Atia, Taggart, Michael J., Blanks, Andrew M., van den Berg, H. A., Thornton, Steve, Catalano, Roberto, Blanks, AM, Samantha McCavera, Rand, D. A., Blanks, Andrew, Denton, Jerod, Lin, N, Taggart, Michael, Wright, Paul, Bailey, E, Elizabeth Bailey, Anatoly Shmygol   +100 more
core   +1 more source

Dorso-Ventral and Night-Day Regulation of Extracellular K⁺ Dynamics in Mouse Hippocampal Astrocytes. [PDF]

Glia
Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Kiani N, Abubakar K, Petanjek TL, Esclapez M, Ivanov A, Bernard C.   +5 more
europepmc   +2 more sources

Evidence for the Direct Interaction of Spermine with the Inwardly Rectifying Potassium Channel [PDF]

Journal of Biological Chemistry, 2009
The inwardly rectifying potassium channel (Kir) regulates resting membrane potential, K+ homeostasis, heart rate, and hormone secretion. The outward current is blocked in a voltage-dependent manner, upon the binding of intracellular polyamines or Mg2+ to the transmembrane pore domain. Meanwhile, electrophysiological studies have shown that mutations of
Masanori, Osawa, Mariko, Yokogawa, Takahiro, Muramatsu, Tomomi, Kimura, Yoko, Mase, Ichio, Shimada   +5 more
openaire   +2 more sources

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

G-protein mediated trafficking of inwardly rectifying potassium channels [PDF]

, 2008
Understanding the mechanisms which regulate trafficking and surface expression of membrane-associated proteins is crucial to understanding their function in a physiological context.
Boyer, Stephanie B.
core  

The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation [PDF]

, 2005
Background— The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated IK,ACh contributes to enhanced basal ...
Ravens, U., Wettwer, E., Christ, T., Voigt, N., Friedrich, A., Knaut, M., Jost, Norbert, Dobrev, D.   +7 more
core   +1 more source