Results 61 to 70 of about 12,064 (247)
iScienceSummary: There is a paucity of information pertaining to the fundamental roles of glia in insect central nervous system (CNS) function and in the maintenance of ionic gradients. Inward rectifier potassium (Kir) channels are known to drive K+ buffering in
Rui Chen +3 more
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Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
BMC Cancer, 2004 Background Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways.
Cakir Yavuz +3 more
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Frontiers in Pharmacology, 2011 The periodic paralysis(PP) are rare autosomal-dominant disorders associated to mutations in the skeletal muscle sodium, calcium and potassium channel genes characterized by muscle fiber depolarization with un-excitability, episodes of weakness with ...
Domenico eTricarico +1 more
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CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley +1 more source
Determination of the subunit stoichiometry of an inwardly rectifying potassium channel
Neuron, 1995 Inwardly rectifying K+ channels are distantly related to their voltage-gated counterparts and possess a structural motif of only two putative transmembrane segments in each subunit. They are formed by the assembly of an unknown number of subunits. We have examined the subunit stoichiometry of a strongly rectifying K+ channel, IRK1, by linking together ...
Yang, Jian, Jan, Yuh Nung, Jan, Lily Yeh
openaire +2 more sources
In Vitro Reconstruction of Axonal Heat Sensing with a Photothermal Nerve‐on‐a‐Chip
Small, EarlyView.A photothermal nerve‐on‐a‐chip platform is presented that enables precise, localized heating of sensory axons with simultaneous electrical recording. The system reveals millisecond‐scale dynamics of heat‐evoked neural activity and provides a new approach to study how temperature‐dependent ion channel behavior is translated into axonal firing.
Koji Sakai +6 more
wiley +1 more source
G-protein mediated trafficking of inwardly rectifying potassium channels [PDF]
, 2008 Understanding the mechanisms which regulate trafficking and surface expression of membrane-associated proteins is crucial to understanding their function in a physiological context.
Boyer, Stephanie B.
core
Frontiers in Molecular Neuroscience, 2011 We introduce a molecular toolbox for manipulation of neuronal gene expression in vivo. The toolbox includes promoters, ion channels, optogenetic tools, fluorescent proteins and intronic artificial microRNAs. The components are easily assembled into adeno-
Melanie D. White +2 more
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The FEBS Journal, EarlyView.Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti +3 more
wiley +1 more source