Results 81 to 90 of about 19,097 (250)

Inwardly Rectifying Potassium Channels: Their Molecular Heterogeneity and Function.

The Japanese Journal of Physiology, 1997
A variety of cells including cardiac myocytes and neuronal cells possess inwardly rectifying K+ (Kir) channels through which currents flow more readily in the inward direction than outward. These K+ channels play pivotal roles in maintenance of the resting membrane potential, in regulation of the action potential duration, in receptor-dependent ...
S, Isomoto, C, Kondo, Y, Kurachi
openaire   +3 more sources

Multiple PIP₂ binding sites in Kir2.1 inwardly rectifying potassium channels [PDF]

FEBS Letters, 2001
Inwardly rectifying potassium channels require binding of phosphatidylinositol‐4,5‐bisphosphate (PIP2) for channel activity. Three independent sites (aa 175–206, aa 207–246, aa 324–365) were located in the C‐terminal domain of Kir2.1 channels by assaying the binding of overlapping fragments to PIP2 containing liposomes.
Soom, Malle, Schönherr, Roland, Kubo, Yoshihiro, Kirsch, Cornelia, Klinger, Reinhard, Heinemann, Stefan H.   +5 more
openaire   +2 more sources

In Vitro Reconstruction of Axonal Heat Sensing with a Photothermal Nerve‐on‐a‐Chip

Small, EarlyView.
A photothermal nerve‐on‐a‐chip platform is presented that enables precise, localized heating of sensory axons with simultaneous electrical recording. The system reveals millisecond‐scale dynamics of heat‐evoked neural activity and provides a new approach to study how temperature‐dependent ion channel behavior is translated into axonal firing.
Koji Sakai, Yujiro Tanaka, Riku Takahashi, Toichiro Goto, Yosuke Mizuno, Taiki Otomo, Aya Tanaka   +6 more
wiley   +1 more source

Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes

Frontiers in Molecular Neuroscience, 2017
Inwardly rectifying potassium (Kir) 4.1 channels in astrocytes regulate neuronal excitability by mediating spatial potassium buffering. Although dysfunction of astrocytic Kir4.1 channels is implicated in the development of epileptic seizures, the ...
Masato Kinboshi, Masato Kinboshi, Masato Kinboshi, Takahiro Mukai, Yuki Nagao, Yusuke Matsuba, Yoshimi Tsuji, Shiho Tanaka, Kentaro Tokudome, Kentaro Tokudome, Saki Shimizu, Hidefumi Ito, Akio Ikeda, Atsushi Inanobe, Yoshihisa Kurachi, Seiji Inoue, Yukihiro Ohno   +16 more
doaj   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Amyloid-β induces synaptic dysfunction through G protein-gated inwardly rectifying potassium channels in the fimbria-CA3 hippocampal synapse

Frontiers in Cellular Neuroscience, 2013
Last evidences suggest that, in Alzheimer's disease (AD) early stage, Amyloid-β (Aβ) peptide induces an imbalance between excitatory and inhibitory neurotransmission systems resulting in the functional impairment of neural networks.
Mauricio O. Nava-Mesa, Mauricio O. Nava-Mesa, Lydia eJimenez-Diaz, Javier eYajeya, Juan D Navarro-Lopez   +4 more
doaj   +1 more source

Variable electrophysiology before and after block of the two delayed rectifier potassium channels in groups of isolated rabbit ventricular cells

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Between‐cell differences in ventricular cardiomyocyte action potential duration (APD) and responses to ion channel block may contribute to pro‐arrhythmic dispersion of myocardial repolarisation. This study quantifies between‐cell physiological and pharmacological variability in the rabbit left ventricle (LV) and uses ...
Rebecca J. Gilchrist, Muhamad Hifzhudin Noor Aziz, Francis L. Burton, Radostin D. Simitev, Rachel C. Myles, Godfrey L. Smith   +5 more
wiley   +1 more source

Kir3 channel signaling complexes: Focus on opioid receptor signaling

Frontiers in Cellular Neuroscience, 2014
Opioids are among the most effective drugs to treat severe pain. They produce their analgesic actions by specifically activating opioid receptors located along the pain perception pathway where they inhibit the flow of nociceptive information.
Karim eNagi, Graciela ePineyro
doaj   +1 more source

Andersen-Tawil Syndrome [PDF]

, 2006
Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Smith, Andrew H, Fish, Frank A, Kannankeril, Prince J   +2 more
core   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source