Results 71 to 80 of about 19,097 (250)
Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart [PDF]
, 2009 Background Background K+ channels are the principal determinants of the resting membrane potential (RMP) in cardiac myocytes and thus, influence the magnitude and time course of the action potential (AP). Methods RT-PCR and in situ hybridization are used
Hengtao Zhang +3 more
core +2 more sources
Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels [PDF]
Cell, 1996 Inwardly rectifying potassium channels have an important role in determining the resting potential of the cell. They are tetrameric proteins with two transmembrane segments (M1 and M2), a pore-forming loop (H5), a cytoplasmic N-terminal, and longer C-terminal domain. We have used biochemical and electrophysiological methods to identify regions required
Tinker, Andrew +2 more
openaire +2 more sources
iNew Medicine, EarlyView.ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen +6 more
wiley +1 more source
Gi/o protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN
eLife, 2018 Dopamine (D2) receptors provide autoinhibitory feedback onto dopamine neurons through well-known interactions with voltage-gated calcium channels and G protein-coupled inwardly-rectifying potassium (GIRK) channels.
Fabian Philippart, Zayd M Khaliq
doaj +1 more source
Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat
JCI Insight, 2021 Kir5.1 is an inwardly rectifying potassium (Kir) channel subunit abundantly expressed in the kidney and brain. We previously established the physiologic consequences of a Kcnj16 (gene encoding Kir5.1) knockout in the Dahl salt-sensitive rat (SSKcnj16–/–),
Anna D. Manis +7 more
doaj +1 more source
Unconventional voltage sensing in an inwardly rectifying potassium channel
Journal of General Physiology, 2021 Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with ...
openaire +2 more sources
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley +1 more source
Brain Sciences, 2020 Epilepsy, characterized by recurrent seizures, affects 1% of the general population. Interestingly, 25% of diabetics develop seizures with a yet unknown mechanism. Hyperglycemia downregulates inwardly rectifying potassium channel 4.1 (Kir4.1) in cultured
Miguel P. Méndez-González +6 more
doaj +1 more source
Genetic deletion of laminin isoforms β2 and γ3 induces a reduction in Kir4.1 and aquaporin-4 expression and function in the retina. [PDF]
PLoS ONE, 2011 Glial cells such as retinal Müller glial cells are involved in potassium ion and water homeostasis of the neural tissue. In these cells, inwardly rectifying potassium (Kir) channels and aquaporin-4 water channels play an important role in the process of ...
Petra G Hirrlinger +8 more
doaj +1 more source
The role of Mg2+ in the inactivation of inwardly rectifying K+ channels in aortic endothelial cells. [PDF]
, 1995 We have studied the role of Mg2+ in the inactivation of inwardly rectifying K+ channels in vascular endothelial cells. Inactivation was largely eliminated in Mg(2+)-free external solutions and the extent of inactivation was increased by raising Mg2+o ...
Elam, TR, Lansman, JB
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