Results 101 to 110 of about 12,064 (247)

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels?

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV, Giblin, JP, Clapp, LH, Tinker, A, Cui, Y   +4 more
core  

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Envolvimento de diferentes tipos de canais de potássio no efeito tipo-antidepressivo do ácido ascórbico no teste de suspensão pela cauda [PDF]

, 2013
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Considerando que a administração de ácido ascórbico causa um efeito tipo-antidepressivo em camundongos por um mecanismo que envolve uma interação com ...
Ribeiro, Camille Mertins
core  

Distinct expression patterns of inwardly rectifying potassium currents in developing cerebellar granule cells of the hemispheres and the vermis

, 2016
G-protein-coupled inwardly rectifying potassium (GIRK) channels play a crucial role during the migration and maturation of cerebellar granule cells (GCs) in the vermis.
Cesaroni V., Lujan R., Rossi P., Romano C., Brandalise F., Gerber U., Leone R., Lodola F.   +7 more
core   +2 more sources

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

High-yield production and characterization of functional Kir2.1 ion channel using E. coli cell-free protein synthesis system

Synthetic and Systems Biotechnology
A family of inwardly-rectifying potassium (Kir) channels plays a key role in the regulation of cellular potassium (K+) balance, affecting muscle, nerve and immune function.
Tianqi Zhou, Zitong Zhao, Huizi Zhang, Yunyang Song, Yifeng Yin, Fanghui Wu, Yanli Liu, Dan Xu   +7 more
doaj   +1 more source

Inwardly rectifying potassium channels [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2005
O. Sleator, S. Prince
openaire   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines.

, 2007
ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core  

Intercalated disk structure, tissue heterogeneity and ion channel distribution modulate conduction and local calcium influx

The Journal of Physiology, EarlyView.
Abstract figure legend A, three‐dimensional representation of cardiac intercalated disk, reduced to a 100‐partition, computationally efficient network representation. B, ion dynamics within intercalated disk extracellular cleft space. C, rapid pacing leads to localized conduction block in tissue with regions of perturbed intercalated disk (ID ...
Nicolae Moise, Heather L. Struckman, James W. Smyth, Gregory S. Hoeker, Steven Poelzing, Rengasayee Veeraraghavan, Seth H. Weinberg   +6 more
wiley   +1 more source