Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels.
PLoS ONE, 2015 Dietary and metabolic therapies are increasingly being considered for a variety of neurological disorders, based in part on growing evidence for the neuroprotective properties of the ketogenic diet (KD) and ketones.
Do Young Kim +7 more
doaj +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A, three‐dimensional representation of cardiac intercalated disk, reduced to a 100‐partition, computationally efficient network representation. B, ion dynamics within intercalated disk extracellular cleft space. C, rapid pacing leads to localized conduction block in tissue with regions of perturbed intercalated disk (ID ...
Nicolae Moise +6 more
wiley +1 more source
Ion channels: structural basis for function and disease. [PDF]
, 1996 Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core +1 more source
Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin
The Journal of Physiology, EarlyView.Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George +5 more
wiley +1 more source
ATP-sensitive inwardly rectifying potassium channel regulation of viral infections in honey bees
Scientific Reports, 2017 Honey bees are economically important pollinators of a wide variety of crops that have attracted the attention of both researchers and the public alike due to unusual declines in the numbers of managed colonies in some parts of the world.
Scott T. O’Neal +2 more
doaj +1 more source
What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]
, 2012 Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor +11 more
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Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing
, 2006 Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium oscillations (CaOs ...
A. P. R. Theuvenet +9 more
core +1 more source
Erg currents support electrical bursting in murine anterior pituitary corticotrophs
The Journal of Physiology, EarlyView.Abstract figure legend Anterior pituitary corticotrophs are a central component of the hypothalamic‐pituitary‐adrenal (HPA) axis that controls the release of glucocorticoids from the adrenal gland in response to stress. The hypothalamic secretagogue corticotrophin releasing hormone (CRH) promotes electrical bursting of mouse anterior pituitary ...
Sooraj V. Nair +5 more
wiley +1 more source
Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the µ-Opioid Receptor in Xenopus Oocytes [PDF]
, 2001 To determine the sites in the µ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels ...
Celvert, Jeremy P. +4 more
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