Results 131 to 140 of about 12,064 (247)

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Tatulian, L, Hughes, S, Brown, DA, Marsh, SJ, Winks, JS, Filippov, AK   +6 more
core  

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

, 2015
Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
Jennifer L Brignell, Davies Noel W., Challiss, RAJ, Noel W Davies, Carl P. Nelson (7585664), Nelson, CP, Carl P Nelson, Perry, MD, Jonathon M Willets, Perry Matthew D., Brignell, JL, Willets, JM, Davies, NW, Willets Jonathon M., Challiss R. A. John, Brignell Jennifer L., R A John Challiss, Jennifer L. Brignell (7619699), Jonathon M. Willets (7619705), Matthew D Perry, R. A. John Challiss (7585316), Nelson Carl P., Noel W. Davies (707367), Matthew D. Perry (7619702)   +23 more
core   +1 more source

Effects of Different SNP Calling and Sequence Mapping Choices on the Inference of Genetic Architecture Underlying Migration Tendency

Ecology and Evolution, Volume 16, Issue 6, June 2026.
We re‐analysed RAD‐Seq data from brown trout using a conspecific reference genome and alternative SNP pipelines. Population structure was robust across methods, but using the brown trout reference improved detection of biologically relevant outlier SNPs. ABSTRACT Genome‐wide association studies with identification of biologically relevant genes rely on
Giovanna Mottola, Frank Panitz, Tuomas Leinonen, Alexandre Lemopoulos, Anssi Vainikka   +4 more
wiley   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

T‐Cell Acute Lymphoblastic Leukemia in a Young Patient With Andersen–Tawil Syndrome Successfully and Safely Treated With Intensive Chemotherapy Including Potential Precipitating Drugs: A Case Report After 3.5 Years of Follow‐up

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Andersen–Tawil syndrome (ATS) is a rare, hereditary channelopathy characterized by periodic paralysis, cardiac arrhythmias, and sometimes developmental anomalies. No association with hematologic malignancies has previously been reported. We describe the case of a 27‐year‐old man with genetically confirmed Type 1 ATS who developed T‐cell acute ...
Ramy Rahmé, Paule Moussounda Bamba, Thi Thuy Duong Do, Anthony Behin, Estelle Gandjbakhch, Claude Gardin, Thorsten Braun   +6 more
wiley   +1 more source

Molecular gating dynamics of the cytoplasmic domains of inwardly rectifying potassium (Kir) channels [PDF]

, 2006
My research focuses on understanding the mechanisms of eukaryotic inwardly rectifying potassium channels (Kir), which are responsible for creating membrane potential stability. N- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels
Pegan, Scott Dusan
core  

Neurotransmitter Activation of Inwardly Rectifying Potassium Current in Dissociated Hippocampal CA3 Neurons: Interactions among Multiple Receptors

, 1998
We characterized potassium current activated by G-protein-coupled receptors in acutely dissociated hippocampal CA3 neurons. Agonists for serotonin, adenosine, and somatostatin receptors reliably activated a potassium-selective conductance that was ...
Bruce P. Bean, Deborah L. Sodickson
core   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q Correspondence

, 2020
BACKGROUND G protein-coupled inwardly rectifying potassium (KIR3) channels are important proteins that regulate numerous physiological processes including excitatory responses in the CNS and the control of heart rate.
Tin T Yow, Mary Chebib, Nathan Absalom, Jane R Hanrahan, Graham Ar Johnston, Elena Pera, Marika Heblinski   +6 more
core  

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source