Results 141 to 150 of about 19,097 (250)

Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating [PDF]

, 2017
Borschel, William F, Heyman, Sarah, Hsu, Phillip, Nichols, Colin G, Wang, Shizhen   +4 more
core   +2 more sources

A Network Pharmacology and Experimental Validation Strategy for Hypoglycemic Study of Lonicerae Japonicae Flos on Diabetes

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT As diabetes has become an important public health issue, Lonicerae Japonicae Flos (LJF) had gradually attracted increasing attention on diabetes. This study aimed to investigate the hypoglycemic ingredients and underlying mechanisms of LJF in diabetes using an integrated strategy of network pharmacology, molecular docking and experimental ...
Zhang Nan, Liu Xiaolong, Li Chunyan, Ren Lu, Guo Chao, Xue Jintao   +5 more
wiley   +1 more source

Pacemaking in the heart: a redundant and robust system of mutually entrained oscillators driving cardiac automaticity

The Journal of Physiology, Volume 604, Issue 9, Page 3504-3512, 1 May 2026.
Abstract figure legend Cardiac pacemaking: the redundant and robust organ‐to‐subcellular system driving the spontaneous electrical activity responsible for regular, rhythmic excitation of the heart. Abstract The heart is an electrically controlled, mechanical pump that provides a constant supply of blood to the body.
Eilidh A. MacDonald, T. Alexander Quinn
wiley   +1 more source

Potentiation of Opioid-Induced Analgesia by L-Type Calcium Channel Blockers: Need for Clinical Trial in Cancer Pain

Indian Journal of Anaesthesia, 2008
Previous reports indicate that the analgesic effect of opioids is due to both closure of specific voltage-gated calcium channels (N- and P/Q-types) and opening of G protein-coupled inwardly rectifying potassium channels (GIRKs) in neurons concerned with ...
S Basu Ray, Raj D Mehra
doaj  

Episodic disorders: channelopathies and beyond. [PDF]

, 2015
Ptáček, Louis J
core   +1 more source

Prenylcysteine Oxidase 1 Deficiency Protects the Cardiac Muscle Cell Line HL‐1 Against Ischaemic/Hypoxic Stress

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Ischaemic/hypoxic stress leads to heart remodeling and dysfunction. PCYOX1 promotes cardiomyocyte survival during injury, reducing the generation of reactive oxygen species. PCYOX1 deficiency regulates key proteins to preserve cardiomyocyte structure and function such as creatine kinase.
Cristina Banfi, Lisa Brocca, Alice Bascucci, Giulia Giusy Papaianni, Alice Mallia, Sonia Eligini   +5 more
wiley   +1 more source

Ligand transduction mechanisms of inwardly-rectifying potassium channels

, 2013
Regulation of inwardly-rectifying potassium (Kir) channels by intracellular ligands couples cell membrane excitability to important signaling cascades and metabolic pathways. Particularly, the ATP-sensitive potassium (KATP) channels, highly expressed in diverse excitable tissues, are the keystone components of glucose-stimulated insulin secretion in ...
openaire   +1 more source

Pathophysiology of homocysteine: insights into ion channel dysfunction. [PDF]

Pflugers Arch
Chmúrčiaková N, Stringer RN, Cmarko L, Filipova A, Lacinova L, Weiss N.   +5 more
europepmc   +1 more source

Novel Mutations in KCNJ10 Gene Associated With SeSAME Syndrome: Rare Disorder With Possible Common Mutation. [PDF]

Mol Genet Genomic Med
Shakeri S, Mohammadi S, Sadeghipour F, Masoudi M, Entezam M.   +4 more
europepmc   +1 more source

Müller cell markers in aqueous humor of patients with type-2 macular telangiectasia. [PDF]

Indian J Ophthalmol
Osmanlı E, Sül S, Kaderli A, Kaderli ST, Türkçü Ü.   +4 more
europepmc   +1 more source