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Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
Nature, 1993A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger ...
K, Ho +6 more
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Direct Activation of an Inwardly Rectifying Potassium Channel by Arachidonic Acid
Molecular Pharmacology, 2001Arachidonic acid (AA) is an important constituent of membrane phospholipids and can be liberated by activation of cellular phospholipases. AA modulates a variety of ion channels via diverse mechanisms, including both direct effects by AA itself and indirect actions through AA metabolites.
Y, Liu +8 more
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Cholesterol Binding Sites in Inwardly Rectifying Potassium Channels
2019Inwardly rectifying potassium (Kir) channels play a variety of critical cellular roles including modulating membrane excitability in neurons, cardiomyocytes and muscle cells, and setting the resting membrane potential, heart rate, vascular tone, insulin release, and salt flow across epithelia.
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[Cardiac inwardly rectifying potassium channel and arrhythmias].
Sheng li xue bao : [Acta physiologica Sinica], 2015The cardiac inwardly rectifying potassium channel (I(K1)), which is mainly expressed in mammalian atrial and ventricular myocytes, has been considered as the primary conductance controlling the resting potential (RP) and permitting a significant repolarizing current during the terminal phase of action potential.
Bo-Wei, Wu, Qing-Hua, Liu, Li, Zhang
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Inwardly-rectifying potassium channels are blocked by bupivacaine
Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control, 1988D.E. Coyle, N. Sperelakis, G.M. Wahler
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