Results 1 to 10 of about 2,514 (84)

Dorso-Ventral and Night-Day Regulation of Extracellular K⁺ Dynamics in Mouse Hippocampal Astrocytes. [PDF]

Glia
Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Kiani N, Abubakar K, Petanjek TL, Esclapez M, Ivanov A, Bernard C.   +5 more
europepmc   +2 more sources

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player? [PDF]

J Neurosci Res
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Lange J, Zhao E, O'Connell E, Gillham O, McTague A.   +4 more
europepmc   +2 more sources

Paroxysmal Kinesigenic Dyskinesia and Progressive Ataxia-Spasticity Syndrome Caused by a Biallelic Variant in KCNJ10. [PDF]

Mov Disord Clin Pract
Movement Disorders Clinical Practice, EarlyView.
Desjardins C, Baik J, Bresciani L, Nilles C, Foucard C, Georget M, Daghsen L, Degos B, Méneret A, Roze E.   +9 more
europepmc   +2 more sources

Emerging Roles of Astrocyte Kir4.1 Channels in the Pathogenesis and Treatment of Brain Diseases [PDF]

International Journal of Molecular Sciences, 2021
Yukihiro Ohno, Saki Shimizu
exaly   +2 more sources

Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels [PDF]

Journal of Biological Chemistry
Jonathan Mount, Colin Nichols, Sun-Joo Lee   +2 more
exaly   +2 more sources

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H. Eid   +5 more
wiley   +1 more source

Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms

Advanced Biology, Volume 10, Issue 8, August 2026.
Ghrelin excites the dentate gyrus (DG) granule cells via GHSR‐mediated modulation of diverse ionic channels and activation of D1R, cAMP, and EPAC2. Similarly, overnight calorie restriction alters neuronal excitability in a ghrelin‐dependent manner. Infusion of ghrelin directly into the DG improves short‐term spatial memory in the Y‐maze, providing ...
Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei   +3 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source