Role of Kir4.1 Channels in Aminoglycoside-Induced Ototoxicity of Hair Cells. [PDF]
Biomed Res Int, 2023 The Kir4.1 channel, an inwardly rectifying potassium ion (K+) channel, is located in the hair cells of the organ of Corti as well as the intermediate cells of the stria vascularis.
Choi JS +6 more
europepmc +6 more sources
Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes. [PDF]
Invest Ophthalmol Vis Sci, 2020 Purpose Diabetic retinopathy (DR) is a leading cause of visual impairment. Müller cells in DR are dysfunctional due to downregulation of the inwardly rectifying potassium channel Kir4.1.
Alex A +4 more
europepmc +4 more sources
The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. [PDF]
PLoS Comput Biol, 2015 International audienceNeuronal excitability relies on inward sodium and outward potassium fluxes during action potentials. To prevent neuronal hyperexcitability, potassium ions have to be taken up quickly.
Sibille J +3 more
europepmc +7 more sources
Kir4.1 channels contribute to astrocyte CO<sub>2</sub>/H<sup>+</sup>-sensitivity and the drive to breathe. [PDF]
Commun BiolAstrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO2/H+, however, it is not clear how these cells detect changes in CO2/H+.
Cleary CM +10 more
europepmc +6 more sources
Contribution of astrocytic Kir4.1 channels in mechanical allodynia
, 2020 La douleur inflammatoire chronique est une affection fréquente et invalidante qui est maintenue par une sensibilisation centrale, responsable de l’apparition de l’hypersensibilité douloureuse.
Mountadem, Sarah
core +3 more sources
KIR4.1: K+ Channel Illusion or Reality in the Autoimmune Pathogenesis of Multiple Sclerosis [PDF]
Frontiers in Molecular Neuroscience, 2016 Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Many believe autoimmune pathogenesis plays a key role in MS, but its target(s) remains elusive.
Chen Gu
core +5 more sources
Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1 channels
American Journal of Physiology-Cell Physiology, 2000 Kir1.1 (ROMK1) is inhibited by hypercapnia and intracellular acidosis with midpoint pH for channel inhibition (p K a) of ∼6.7. Another close relative, Kir4.1 (BIR10), is also pH sensitive with much lower pH sensitivity (p K a ∼6.0), although it shares a
Wangzhen Shen +9 more
core +3 more sources
Deeper and Deeper on the Role of BK and Kir4.1 Channels in Glioblastoma Invasiveness: A Novel Summative Mechanism? [PDF]
Front Neurosci, 2020 In the last decades, increasing evidence has revealed that a large number of channel protein and ion pumps exhibit impaired expression in cancers. This dysregulation is responsible for high proliferative rates as well as migration and invasiveness ...
Brandalise F +7 more
europepmc +3 more sources
Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. [PDF]
Int J Mol Sci, 2019 The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy.
Kinboshi M +7 more
europepmc +2 more sources
Astrocytic Kir4.1 channels and gap junctions account for spontaneous epileptic seizure. [PDF]
PLoS Comput Biol, 2018 Experimental recordings in hippocampal slices indicate that astrocytic dysfunction may cause neuronal hyper-excitation or seizures. Considering that astrocytes play important roles in mediating local uptake and spatial buffering of K+ in the extracellular space of the cortical circuit, we constructed a novel model of an astrocyte-neuron network module ...
Du M, Li J, Chen L, Yu Y, Wu Y.
europepmc +6 more sources