The FASEB Journal, 2011 The Kir4.1 channel is expressed in the brainstem, retina and kidney. Its heteromerization with Kir5.1 leads to K + currents with distinct properties such as single‐channel conductance, rectification, pH sensitivity and phosphorylation modulations.
Xin Jin +4 more
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Kir4.1 K+channels are regulated by external cations [PDF]
Channels, 2011 The inwardly rectifying potassium channel (Kir), Kir4.1 mediates spatial K(+)-buffering in the CNS. In this process the channel is potentially exposed to a large range of extracellular K(+) concentrations ([K(+)]o). We found that Kir4.1 is regulated by K(+)o.
Johan M, Edvinsson +2 more
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Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis [PDF]
New England Journal of Medicine, 2012 Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known.We screened serum IgG from persons with multiple sclerosis to identify antibodies that are capable of binding to brain tissue and ...
Rajneesh, Srivastava +12 more
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Variable loss of Kir4.1 channel function in SeSAME syndrome mutations [PDF]
Biochemical and Biophysical Research Communications, 2010 SeSAME syndrome is a complex disease characterized by seizures, sensorineural deafness, ataxia, mental retardation and electrolyte imbalance. Mutations in the inwardly rectifying potassium channel Kir4.1 (KCNJ10 gene) have been linked to this condition. Kir4.1 channels are weakly rectifying channels expressed in glia, kidney, cochlea and possibly other
Xiaofang, Tang +3 more
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Functional interaction between aquaporins and Kir4.1/Kir4.1‐Kir5.1 channels
The FASEB Journal, 2007 In the CNS glial cells, Kir4.1 and Kir4.1‐Kir5.1 channels are involved in clearance of K + during neuronal activity. A number of studies have shown that Kir channels are co‐localized with aquaporins (AQP4) in the glial cells, and coupled water and K ...
Rikke Søe, Dan Arne Klærke
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Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis [PDF]
Glia, 2009 AbstractThe weakly inwardly rectifying K+channel Kir4.1 is found in many glial cells including astrocytes. However, questions remain regarding the relative contribution of Kir4.1 to the resting K+conductance of mature astrocytes in situ. We employed a bacterial artificial chromosome transgenic approach in mice to visualize Kir4.1 expression in vivo ...
Xiaofang, Tang +2 more
openaire +2 more sources
Astrocytic ion channel Kir4.1 deficit underlies chronic pain. [PDF]
Neural Regen ResMountadem S +3 more
europepmc +3 more sources
Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy. [PDF]
Sci Rep, 2016 Dysfunction of the inwardly-rectifying potassium channels Kir4.1 (KCNJ10) represents a pathogenic mechanism contributing to Autism-Epilepsy comorbidity.
Sicca F +17 more
europepmc +2 more sources
Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells [PDF]
, 2018 Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels.
Yucheng Xiao (345455) +19 more
core +2 more sources
Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis. [PDF]
, 2009 The inwardly-rectifying potassium channel subunit Kir5.1 selectively co-assembles with members of the Kir4.0 subfamily to form novel pH-sensitive heteromeric channels with unique single channel properties.
Tucker, Stephen +6 more
core +1 more source