Results 41 to 50 of about 800,201 (140)

Detection of potassium channel KIR4.1 antibodies in Multiple Sclerosis patients

Journal of Immunological Methods, 2017
The presence of KIR4.1 antibodies has been proposed to be a characteristic of Multiple Sclerosis (MS). This could have a significant impact on disease management. However, the validation of the initial findings has failed till date. Conflicting results have been attributed to difficulties in isolating the lower-glycosylated (LG) KIR4.1 expressed in ...
Marnetto F., Valentino P., Caldano M., Bertolotto A.   +3 more
openaire   +3 more sources

The Role of the Glutamate–Glutamine Cycle in Synaptic Transmission During Ischemia and Recovery

European Journal of Neuroscience, Volume 64, Issue 1, July 2026.
We show that severe ischemia results in loss of ion homeostasis, extracellular glutamate accumulation and disrupted glutamate release. Synaptic transmission failure is mainly caused by reduced astrocytic EAAT‐mediated glutamate uptake, driven by the collapse of the sodium gradient.
Hannah van Susteren, Christine R. Rose, Michel J. A. M. van Putten, Hil G. E. Meijer   +3 more
wiley   +1 more source

Kir4.1 channels regulate swelling of astroglial processes in experimental spinal cord edema

, 2007
In glial cells, inwardly rectifying K+ channels (Kir) control extracellular [K+](o) homeostasis by uptake of K+ from the extracellular space and release of K+ into the microvasculature.
Kirchhoff, Frank, Kaiser, Melanie, Melanie Kaiser, Hirrlinger, Johannes, Neusch, Clemens, Johannes Hirrlinger, Frank Kirchhoff, Clemens Neusch, Payam Dibaj, Dibaj, Payam   +9 more
core   +1 more source

Oxidative Stress Suppresses The Heteromeric Kir4.1-Kir5.1 Channel Via S-Glutathionylation [PDF]

, 2013
Potassium transport channels regulate cellular excitability and membrane potentials. Dysfunction of potassium channels may happen under certain pathophysiological conditions via post-translational modification (PTM), inducing the S-glutathionylation, in ...
Wu, Yang
core   +1 more source

HNF1B as a New Transcriptional Activator of the Renal KIR4.1/KIR5.1 Potassium Channel [PDF]

The FASEB Journal, 2017
Background Hepatocyte nuclear factor 1 homeobox B ( HNF1B) is an essential transcription factor for the development and functioning of the kidney.
Kompatscher, A., de Baaij, J.H.F., Aboudehen, K., Hoefnagels, A., Igarashi, P., Bindels, R.J.M., Veenstra, G.J.C., Hoenderop, J.G.J.   +7 more
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.

, 2007
Inhibition by intracellular H(+) (pH gating) and activation by phosphoinositides such as PIP(2) (PIP(2)-gating) are key regulatory mechanisms in the physiology of inwardly-rectifying potassium (Kir) channels.
Sansom, MS, Tucker, Stephen, Tucker, SJ, Paynter, JJ, Fowler, PW, Rapedius, M, Shang, Lijun, Baukrowitz, T, Shang, L   +8 more
core   +1 more source

Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development andIn VivoMyelination [PDF]

The Journal of Neuroscience, 2001
To understand the cellular and in vivo functions of specific K(+) channels in glia, we have studied mice with a null mutation in the weakly inwardly rectifying K(+) channel subunit Kir4.1. Kir4.1-/- mice display marked motor impairment, and the cellular basis is hypomyelination in the spinal cord, accompanied by severe spongiform vacuolation, axonal ...
Neusch, Clemens, Rozengurt, Nora, Jacobs, Russell E., Lester, Henry A., Kofuji, Paulo   +4 more
openaire   +4 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, Volume 4, Issue 2, June 2026.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source