Results 51 to 60 of about 800,201 (140)

Tumor Necrosis Factor Alpha (TNF-α) Disrupts Kir4.1 Channel Expression Resulting in Müller Cell Dysfunction in the Retina [PDF]

, 2017
Purpose: Diabetic patients often are affected by vision problems. We previously identified diabetic retinopathy (DR) as a disease of clock gene dysregulation. TNF-α, a proinflammatory cytokine, is known to be elevated in DR. Müller cells maintain retinal
Iraj Hassan, Dominguez, James M., Qianyi Luo, Luo, Qianyi, Julia V. Busik, Sreeparna Majumdar, Hassan, Iraj, Bhatwadekar, Ashay D., James M. Dominguez, Majumdar, Sreeparna, Ashay D. Bhatwadekar, Busik, Julia V.   +11 more
core   +1 more source

EAST/SeSAME syndrome mutations partially disrupt trafficking of homomeric Kir4.1 channels and produce non‐functional heteromeric Kir2.3/Kir4.1 channels

The FASEB Journal, 2012
Mutations in Kir4.1 cause renal salt and Mg wasting (EAST/ SeSAME syndrome, E/S) within the DCT. We have recently found that WT Kir4.1 co‐assembles and co‐localizes with Kir2.3 to produce heteromeric channels with properties similar to native channels in distal nephron. We previously reported that E/S Kir4.1 mutants disrupt Kir2.3 function, raising the
Bernardo Ortega, Dimin Li, Bo-Young Kim, James B Wade, Paul A Welling   +4 more
openaire   +1 more source

Protein‐Template Gold Nanoclusters Induce Differentiation and Modify the Functional Properties of Primary Astrocytes

Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.
The incubation of primary astrocytes with fAuNCs‐BSA induces: (A) long‐term effects including fAuNCs‐BSA internalization, red cell fluorescence, differentiation, upregulation of Ca2+ signaling, Cl‐current, and cell volume regulation. B) Short‐term (200 ms) stimulation with UV LED light increases in Ca2+ signaling and inhibition of K+ current. Astrocyte
Roberta Fabbri, Karima Jeneh Perry, Emanuela Saracino, Chiara Lazzarini, Anna Mariano, Diletta Spennato, Maria Grazia Mola, Maria Grazia Raucci, Alessandro Kovtun, Marianna Barbalinardo, Giorgia Conte, Denis Gentili, Marco Caprini, Vincenzo Palermo, Roberto Zamboni, Luigi Ambrosio, Wolfgang Losert, Andrea Candini, Grazia Paola Nicchia, Raj K. Gupta, Valentina Benfenati, Shashi P. Karna   +21 more
wiley   +1 more source

Cancer: A bioelectric disease?

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
The membrane potential (Vm) has emerged as a systems‐level regulator of cancer cell behaviour, linking ion channel activity to processes such as proliferation, differentiation and therapeutic response. This framework provides a roadmap for translating Vm measurement and validation into bioelectric precision medicine, integrating multi‐omics and ...
Celine Desoyer, Roko Šupe, Sahar Ghorbanpour, Debkalpa Goswami, Mina Khalaj, Nazanin Karami, Dagmar Brislinger, Charlotte A. E. Hauser, Christian Baumgartner   +8 more
wiley   +1 more source

Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions.

, 2014
Objective: Serum antibodies against the glial potassium channel KIR4.1 are found in a subpopulation of multiple sclerosis (MS) patients. Little is known about the expression of KIR4.1 in human normal brain tissue and in MS lesions.
Srivastava, R., Kalluri, S.R., Boettinger, S., Schlegel, J., Gempt, J., Carassiti, D., Hemmer, B., Herwerth, M., Kuhlmann, T., Srivastava, B., Reynolds, R., Korn, T., Schirmer, L.   +12 more
core   +2 more sources

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, Volume 10, Issue 10, 22 May 2026.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Opposite effects of pH on open‐state probability and single channel conductance of Kir4.1 channels

The Journal of Physiology, 1999
1. A decrease in intracellular pH (pHi) inhibits whole-cell Kir4.1 currents. To understand channel biophysical properties underlying this inhibition, single channel Kir4.1 currents were studied in inside-out patches using symmetric concentrations of K+ applied to each side of the plasma membrane.
Z, Yang, C, Jiang
openaire   +3 more sources

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Pathological Roles of Astrocytes in Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu, Yuxiao Ma, Baofeng Wang, Yongtao Zheng, Jie Ren, Qingfang Sun, Liuguan Bian, Yuhao Sun   +7 more
wiley   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source