Results 31 to 40 of about 800,201 (140)
The emerging role of the inwardly rectifying K+ channels in autism spectrum disorders and epilepsy [PDF]
, 2011 Autism is a complex behavioral disorder that develops prior to age three years and is distinguished by high heritability. Many genes predisposing to autism spectrum disorders (ASDs) have been identified.
Roscini, Mauro +7 more
core
Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity [PDF]
, 2018 Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of KCNJ10, which encodes the inward-rectifying potassium channel KIR4.1, causes seizures and progressive ...
Timmons G +20 more
core +5 more sources
Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels. [PDF]
, 2003 Heteromultimerization between different potassium channel subunits can generate channels with novel functional properties and thus contributes to the rich functional diversity of this gene family.
Tucker, Stephen +8 more
core +1 more source
Reduction of Kir4.1 channel activity in an oxidative stress‐related aging model
The FASEB Journal, 2021 Aging is a major risk factor for many chronic diseases that predisposes to impairment of cellular function via several mechanisms, including oxidative stress (OS) which exerts its action on plasma membrane and transport systems, affecting thus cell homeostasis. Among experimental aging models,
Remigante, A +8 more
openaire +2 more sources
Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels. [PDF]
, 2007 Comparison of the crystal structures of the KcsA and MthK potassium channels suggests that the process of opening a K(+) channel involves pivoted bending of the inner pore-lining helices at a highly conserved glycine residue.
Tucker, Stephen +3 more
core +1 more source
Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke
eBioMedicine, 2023 Stroke is one of the most common neurological diseases in the world and is clinically manifested by transient or permanent brain dysfunction. It has a high mortality and disability rate, which severely affects people's health and diminishes the quality of life. However, there is no efficient treatment that can be considered curative and there are other
Xiaoqi Hong +9 more
openaire +2 more sources
Kir4.1 Channel Expression Is Essential for Parietal Cell Control of Acid Secretion [PDF]
Journal of Biological Chemistry, 2011 Kir4.1 channels were found to colocalize with the H(+)/K(+)-ATPase throughout the parietal cell (PC) acid secretory cycle. This study was undertaken to explore their functional role. Acid secretory rates, electrophysiological parameters, PC ultrastructure, and gene and protein expression were determined in gastric mucosae of 7-8-day-old Kir4.1 ...
Song, Penghong +9 more
openaire +3 more sources
Potassium channel Kir4.1 macromolecular complex in retinal glial cells
Glia, 2005 AbstractA major role for Müller cells in the retina is to buffer changes in the extracellular K+ concentration ([K+]o) resulting from light‐evoked neuronal activity. The primary K+ conductance in Müller cells is the inwardly rectifying K+ channel Kir4.1.
Nathan C, Connors, Paulo, Kofuji
openaire +2 more sources
Cell Proliferation, Volume 59, Issue 7, July 2026.Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon +6 more
wiley +1 more source
, 2018 Inward rectifying potassium (Kir) channels comprise a large family with diverse biophysical properties. A predominant feature of central nervous system (CNS) glia is their expression of Kir4.1, which as homomers are weakly rectifying channels, but form ...
Csilla Brasko, Arthur Butt
core +1 more source