Results 1 to 10 of about 183,075 (317)

Errors in the measurement of voltage-activated ion channels in cell-attached patch-clamp recordings

Nature Communications, 2011
Patch-clamp recording techniques have revolutionized understanding of the function and sub-cellular location of ion channels in excitable cells. The cell-attached patch-clamp configuration represents the method of choice to describe the endogenous ...
Stephen R. Williams, C. Wozny
semanticscholar   +2 more sources

The contribution of delta subunit-containing GABAA receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex.

Frontiers in Neural Circuits, 2013
We have made use of the delta subunit-selective allosteric modulator DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl benzamide) to assay the contribution of delta-GABAARs to tonic and phasic conductance changes in the cerebellum, thalamus and ...
Stephen G Brickley, Zhiwen eYe, Thomas P McGee, Catriona M Houston   +3 more
doaj   +1 more source

Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats

Iranian Journal of Medical Sciences, 2016
Background: Ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. The mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown.
Chengdong Yuan, Yajun Zhang, Yu Zhang, Song Cao, Yuan Wang, Bao Fu, Tian Yu   +6 more
doaj  

Activation of rat transient receptor potential cation channel subfamily V member 1 channels by 2-aminoethoxydiphenyl borate

Integrative Medicine Research, 2013
Background: The transient receptor potential cation channel subfamily V member 1 (TRPV1) channel has been proved to be a molecular integrator of inflammatory pain sensation.
Knara Nazaralievna Mamatova, Tong Mook Kang   +1 more
doaj   +1 more source

Super-Resolution Scanning Patch-Clamp Reveals Clustering of Functional Ion Channels in the Adult Ventricular Myocyte

Circulation Research, 2013
Rationale: Compartmentation of ion channels on the cardiomyocyte surface is important for electric propagation and electromechanical coupling. The specialized T-tubule and costameric structures facilitate spatial coupling of various ion channels and ...
Anamika Bhargava, Xianming Lin, P. Novak, Kinneri Mehta, Y. Korchev, M. Delmar, J. Gorelik   +6 more
semanticscholar   +1 more source

Antivenom Evaluation by Electrophysiological Analysis

Toxins, 2017
Scorpion stings on humans are medically relevant because they may contain toxins that specifically target ion channels. During antivenom production, pharmaceutical companies must use a large number of experimental animals to ensure the antivenom’s ...
Rita Restano-Cassulini, Walter Garcia, Jorge F. Paniagua-Solís, Lourival D. Possani   +3 more
doaj   +1 more source

ASIC currents in cultured primate retinal amacrine/ganglion cells

Physiological Reports
Acid‐sensing ion channels (ASICs) are proton‐gated cation channels belonging to the epithelial Na + channel/degenerin superfamily. In the CNS, ASICs are involved in synaptic plasticity, learning/memory, and acidosis‐mediated injury.
Talib Saafir, Tiandong Leng, Koichi Inoue, Zhi‐Gang Xiong, Peter MacLeish   +4 more
doaj   +1 more source

Cardiac toxicity of Triptergium wilfordii Hook F. may correlate with its inhibition to hERG channel

Heliyon, 2019
Tripterygium wilfordii Hook F. (TWHF) is a Chinese traditional medicine with cardiac toxicities. However, the mechanism of acute cardiac toxicity is not very clear.
Wei Zhao, Liping Xiao, Lanying Pan, Xianfu Ke, Yanting Zhang, Dian Zhong, Jianwei Xu, Fumin Cao, Liren Wu, Yuan Chen   +9 more
doaj   +1 more source

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin

Protein & Cell, 2017
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety ...
Fan Yang, Jie Zheng
doaj   +1 more source

Reduced Ca²⁺ transport across sarcolemma but enhanced spontaneous activity in cardiomyocytes isolated from left atrium-pulmonary veins tissue of myopathic hamster

Journal of Biomedical Science, 2009
Background Several lines of evidence point to a particularly important role of the left atrium (LA) in initiating and maintaining atrial fibrillation (AF). This role may be related to the location of pulmonary veins (PVs) in the LA.
Chen Yao-Chang, Wu Kuo-Ho, Loh Yue-Xia, Hsu Chih-Hsiung, Wei Jeng, Lin Cheng-I   +5 more
doaj   +1 more source