Results 41 to 50 of about 183,075 (317)
Dendritic patch-clamp recordings from cerebellar granule cells demonstrate electrotonic compactness
Frontiers in Cellular Neuroscience, 2015 Cerebellar granule cells (GC), the smallest neurons in the brain, have on average four short dendrites that receive high-frequency mossy fiber inputs conveying sensory information.
Igor eDelvendahl +2 more
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Methadone interrupts neural growth and function in human cortical organoids
Stem Cell Research, 2020 Prenatal opioids exposure can lead to both neonatal abstinence syndrome in newborns and neurological deficits later in life. Although opioids have been well studied in general, the cellular and molecular mechanisms by which opioids affect human fetal ...
Hang Yao +7 more
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Patch clamp techniques for the characterization of membrane channels [PDF]
, 1991 The examples demonstrate that by means of high resolution patch clamp recordings, physiological properties of the cell membrane may be elucidated on the molecular level of individual ion ...
Paschke, Dietmar +2 more
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Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels
eLife, 2016 Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent ...
Hongkang Zhang +2 more
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Heliyon, 2021 Gain-of-function mutations in voltage-gated sodium channels (NaV1.7, NaV1.8, and NaV1.9) are known causes of inherited pain disorders. Identification and functional assessment of new NaV1.7 mutations could help elucidate the phenotypic spectrum of NaV1.7
Kiichi Takahashi +9 more
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Frontiers in Cellular Neuroscience, 2017 During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and firing of CA3 pyramidal cells followed by afterhyperpolarization ...
Ilgam Khalilov +7 more
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Classical and numerical approaches to determining V-section band clamp axial stiffness [PDF]
, 2014 V-band clamp joints are used in a wide range of applications to connect circular flanges, for ducts, pipes and the turbocharger housing. Previous studies and research on V-bands are either purely empirical or analytical with limited applicability on the ...
Khodabakhshi, Goodarz +6 more
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Planar Patch Clamp and Techniques of Patch-Clamp Spectroscopy in Antimicrobial Therapy
Austin Journal of Pharmacology and Therapeutics, 2023 Planar patch-clamp is an effective screening tool in pharmacology, institutionalized in molecular microbiology over 15 years ago [1]. The creation of planar polymer patch-clamp electrodes and silicon substrates in the 2000s [2,3] and the creation of microfluidic chips and perfusable chambers corresponding to this pharmacological screening technology ...
Orehow F, Adamovic E, Gradow O
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Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data
Communications Biology, 2020 Single-molecule research techniques such as patch-clamp electrophysiology deliver unique biological insight by capturing the movement of individual proteins in real time, unobscured by whole-cell ensemble averaging. The critical first step in analysis is
Numan Celik +7 more
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Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels [PDF]
, 2014 Whilst fertilizing capacity depends upon a K+ conductance G? that allows the spermatozoon membrane potential Vm to be held at a negative value, the characteristics of this conductance in human sperm are virtually unknown.
Barratt, C.L.R.; id_orcid +8 more
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