Results 31 to 40 of about 183,075 (317)
Electrophysiological evaluation of the effect of peptide toxins on voltage-gated ion channels: a scoping review on theoretical and methodological aspects with focus on the Central and South American experience [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesThe effect of peptide toxins on voltage-gated ion channels can be reliably assessed using electrophysiological assays, such as the patch-clamp technique.
Jessica Rojas-Palomino +5 more
doaj +1 more source
Heliyon, 2023 Pharmacological studies aimed at the development of newly synthesized drugs directed against ion channels (as well as genetic studies of ion channel mutations) involve the development and use of transfected cells.
Alberto Montalbano +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2014 Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording.
Anton eChizhov +5 more
doaj +1 more source
High conductance anion channel in Schwann cell vesicles from rat spinal roots [PDF]
, 1992 Potassium uptake, possibly together with chloride, is one of the presumed functions of Schwann cells in the peripheral nervous system. However, the presence of chloride channels has not been demonstrated in adult Schwann cells.
Quasthoff, Stefan +5 more
core +1 more source
Q&A: using Patch-seq to profile single cells
BMC Biology, 2017 Individual neurons vary widely in terms of their gene expression, morphology, and electrophysiological properties. While many techniques exist to study single-cell variability along one or two of these dimensions, very few techniques can assess all three
Cathryn R. Cadwell +3 more
doaj +1 more source
An efficient and scalable data analysis solution for automated electrophysiology platforms
SLAS Discovery, 2022 Ion channels are drug targets for neurologic, cardiac, and immunologic diseases. Many disease-associated mutations and drugs modulate voltage-gated ion channel activation and inactivation, suggesting that characterizing state-dependent effects of test ...
Tianbo Li +6 more
doaj +1 more source
Journal of Neuroscience, 1990 We present a functional characterization of a neuronal nicotinic receptor in the CNS using patch-clamp techniques and a preparation of acutely isolated neurons from the medial habenular nucleus of 10- to 20- d-old rats.
Christophe Mulle, J. Changeux
semanticscholar +1 more source
PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery [PDF]
PeerJ, 2023 Background PFI-3 is a small-molecule inhibitor that targets the bromodomains (BRDs) of Brahma-related gene 1 (BRG1). This monomeric compound, which has high selectivity and potent cellular effects, has recently been developed.
Jing Li +13 more
doaj +2 more sources
Frontiers in Pharmacology, 2011 All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders.
Christophe ePy +11 more
doaj +1 more source
Sodium channel inactivation kinetics of rat sensory and motor nerve fibres and their modulation by glutathione [PDF]
, 1993 Na+ channel currents of rat motor and sensory nerve fibres were studied with the patch-clamp technique on enzymatically demyelinated axons. Differences between motor and sensory fibres in multi-channel inactivation kinetics and the gating of late single ...
Quasthoff, Stefan +2 more
core +1 more source