Results 11 to 20 of about 39,769 (255)
Alpha-Adrenoceptor Antagonists Improve Memory by Activating -methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus [PDF]
International Neurourology Journal, 2015 Purpose: Alpha1 (α1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the central nervous system.
Chang Hee Kim +9 more
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The patch-clamp technique in the study of secretion [PDF]
Trends in Neurosciences, 1989 One of the basic cellular functions of virtually every cell type is the exocytotic release of molecules synthesized, stored and packaged into intracellular vesicles or granules. Over decades much effort has been concentrated on elucidating the chain of events leading to exocytosis.
Penner, R., Neher, E.
openaire +4 more sources
Electrophysiological evaluation of the effect of peptide toxins on voltage-gated ion channels: a scoping review on theoretical and methodological aspects with focus on the Central and South American experience [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesThe effect of peptide toxins on voltage-gated ion channels can be reliably assessed using electrophysiological assays, such as the patch-clamp technique.
Jessica Rojas-Palomino +5 more
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Frontiers in Cellular Neuroscience, 2014 Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording.
Anton eChizhov +5 more
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Heliyon, 2023 Pharmacological studies aimed at the development of newly synthesized drugs directed against ion channels (as well as genetic studies of ion channel mutations) involve the development and use of transfected cells.
Alberto Montalbano +4 more
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Q&A: using Patch-seq to profile single cells
BMC Biology, 2017 Individual neurons vary widely in terms of their gene expression, morphology, and electrophysiological properties. While many techniques exist to study single-cell variability along one or two of these dimensions, very few techniques can assess all three
Cathryn R. Cadwell +3 more
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An efficient and scalable data analysis solution for automated electrophysiology platforms
SLAS Discovery, 2022 Ion channels are drug targets for neurologic, cardiac, and immunologic diseases. Many disease-associated mutations and drugs modulate voltage-gated ion channel activation and inactivation, suggesting that characterizing state-dependent effects of test ...
Tianbo Li +6 more
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Comparative Study Between Eversion and Patch Techniques in Carotid Endarterectomy [PDF]
Al-Azhar International Medical JournalBackground: Carotid endarterectomy (CEA) remains a cornerstone therapy for significant carotid stenosis. Eversion CEA may shorten clamp time and potentially influence restenosis, compared with conventional longitudinal endarterectomy with patch ...
Mahsoub Morad +2 more
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PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery [PDF]
PeerJ, 2023 Background PFI-3 is a small-molecule inhibitor that targets the bromodomains (BRDs) of Brahma-related gene 1 (BRG1). This monomeric compound, which has high selectivity and potent cellular effects, has recently been developed.
Jing Li +13 more
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Frontiers in Pharmacology, 2011 All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders.
Christophe ePy +11 more
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