Results 11 to 20 of about 5,720,247 (293)
Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]
, 2013 Direct electrical access to presynaptic ion channels has hitherto been limited to large specialized terminals such as the calyx of Held or hippocampal mossy fiber bouton.
Rusakov, Dmitri A. +26 more
core +1 more source
Alpha-Adrenoceptor Antagonists Improve Memory by Activating -methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus [PDF]
International Neurourology Journal, 2015 Purpose: Alpha1 (α1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the central nervous system.
Chang Hee Kim +9 more
doaj +1 more source
Electrophysiological evaluation of the effect of peptide toxins on voltage-gated ion channels: a scoping review on theoretical and methodological aspects with focus on the Central and South American experience [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesThe effect of peptide toxins on voltage-gated ion channels can be reliably assessed using electrophysiological assays, such as the patch-clamp technique.
Jessica Rojas-Palomino +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2014 Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording.
Anton eChizhov +5 more
doaj +1 more source
Q&A: using Patch-seq to profile single cells
BMC Biology, 2017 Individual neurons vary widely in terms of their gene expression, morphology, and electrophysiological properties. While many techniques exist to study single-cell variability along one or two of these dimensions, very few techniques can assess all three
Cathryn R. Cadwell +3 more
doaj +1 more source
Heliyon, 2023 Pharmacological studies aimed at the development of newly synthesized drugs directed against ion channels (as well as genetic studies of ion channel mutations) involve the development and use of transfected cells.
Alberto Montalbano +4 more
doaj +1 more source
Patch-clamp measurement of ICRAC and ORAI channel activity. [PDF]
, 2014 Depletion of internal Ca(2+) stores activates store-operated Ca(2+) channels. The most prominent members of this class of channels are Ca(2+) release-activated Ca(2+) (CRAC) channels, which are present in a variety of cell types including immune cells ...
Holzmann, Christian +5 more
core +1 more source
Errors in the measurement of voltage-activated ion channels in cell-attached patch-clamp recordings [PDF]
, 2011 Patch-clamp recording techniques have revolutionized understanding of the function and sub-cellular location of ion channels in excitable cells. The cell-attached patch-clamp configuration represents the method of choice to describe the endogenous ...
Wozny, Christian +3 more
core +3 more sources
Comparative Study Between Eversion and Patch Techniques in Carotid Endarterectomy [PDF]
Al-Azhar International Medical JournalBackground: Carotid endarterectomy (CEA) remains a cornerstone therapy for significant carotid stenosis. Eversion CEA may shorten clamp time and potentially influence restenosis, compared with conventional longitudinal endarterectomy with patch ...
Mahsoub Morad +2 more
doaj +1 more source
Frontiers in Pharmacology, 2011 All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders.
Christophe ePy +11 more
doaj +1 more source