Results 21 to 30 of about 5,720,247 (293)
An efficient and scalable data analysis solution for automated electrophysiology platforms
SLAS Discovery, 2022 Ion channels are drug targets for neurologic, cardiac, and immunologic diseases. Many disease-associated mutations and drugs modulate voltage-gated ion channel activation and inactivation, suggesting that characterizing state-dependent effects of test ...
Tianbo Li +6 more
doaj +1 more source
PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery [PDF]
PeerJ, 2023 Background PFI-3 is a small-molecule inhibitor that targets the bromodomains (BRDs) of Brahma-related gene 1 (BRG1). This monomeric compound, which has high selectivity and potent cellular effects, has recently been developed.
Jing Li +13 more
doaj +2 more sources
Dendritic patch-clamp recordings from cerebellar granule cells demonstrate electrotonic compactness
Frontiers in Cellular Neuroscience, 2015 Cerebellar granule cells (GC), the smallest neurons in the brain, have on average four short dendrites that receive high-frequency mossy fiber inputs conveying sensory information.
Igor eDelvendahl +2 more
doaj +1 more source
Planar Patch Clamp and Techniques of Patch-Clamp Spectroscopy in Antimicrobial Therapy
Austin Journal of Pharmacology and Therapeutics, 2023 Planar patch-clamp is an effective screening tool in pharmacology, institutionalized in molecular microbiology over 15 years ago [1]. The creation of planar polymer patch-clamp electrodes and silicon substrates in the 2000s [2,3] and the creation of microfluidic chips and perfusable chambers corresponding to this pharmacological screening technology ...
Orehow F, Adamovic E, Gradow O
openaire +1 more source
Heliyon, 2021 Gain-of-function mutations in voltage-gated sodium channels (NaV1.7, NaV1.8, and NaV1.9) are known causes of inherited pain disorders. Identification and functional assessment of new NaV1.7 mutations could help elucidate the phenotypic spectrum of NaV1.7
Kiichi Takahashi +9 more
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ex vivo patch clamp electrophysiology
, 2023 Containing ex vivo acute brain slice patch clamp electrophysiology data relating to Figure 2 and Table ...
Falkner Lab (17476770)
core +1 more source
Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels
eLife, 2016 Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent ...
Hongkang Zhang +2 more
doaj +1 more source
Methadone interrupts neural growth and function in human cortical organoids
Stem Cell Research, 2020 Prenatal opioids exposure can lead to both neonatal abstinence syndrome in newborns and neurological deficits later in life. Although opioids have been well studied in general, the cellular and molecular mechanisms by which opioids affect human fetal ...
Hang Yao +7 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2017 During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and firing of CA3 pyramidal cells followed by afterhyperpolarization ...
Ilgam Khalilov +7 more
doaj +1 more source
Patch clamp techniques for the characterization of membrane channels [PDF]
, 1991 The examples demonstrate that by means of high resolution patch clamp recordings, physiological properties of the cell membrane may be elucidated on the molecular level of individual ion ...
Paschke, Dietmar +2 more
core +1 more source