Results 51 to 60 of about 5,720,247 (293)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Inhibition of L-type Ca2+ current by ginsenoside Rd in rat ventricular myocytes

Journal of Ginseng Research, 2015
Background: Ginsenoside Rd (GSRd), one of the most abundant ingredients of Panax ginseng, protects the heart via multiple mechanisms including the inhibition of Ca2+ influx.
Cheng Lu, Zhijun Sun, Line Wang
doaj   +1 more source

SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing. [PDF]

PLoS ONE, 2016
Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia.
Andreas M Kist, Dagrun Sagafos, Anthony M Rush, Cristian Neacsu, Esther Eberhardt, Roland Schmidt, Lars Kristian Lunden, Kristin Ørstavik, Luisa Kaluza, Jannis Meents, Zhiping Zhang, Thomas Hedley Carr, Hugh Salter, David Malinowsky, Patrik Wollberg, Johannes Krupp, Inge Petter Kleggetveit, Martin Schmelz, Ellen Jørum, Angelika Lampert, Barbara Namer   +20 more
doaj   +1 more source

Two parallel medial prefrontal cortex-amygdala pathways mediate memory deficits via glutamatergic projection in surgery mice

Cell Reports, 2023
Summary: The neural circuit mechanisms underlying postoperative cognitive dysfunction (POCD) remain elusive. We hypothesized that projections from the medial prefrontal cortex (mPFC) to the amygdala are involved in POCD.
Xiao-Yu Sun, Le Liu, Yu-Tong Song, Tong Wu, Teng Zheng, Jing-Ru Hao, Jun-Li Cao, Can Gao   +7 more
doaj   +1 more source

Biodegradable 3D‐Printable and Coatable Antifouling Composites for Marine Applications

Advanced Functional Materials, EarlyView.
Marine biofouling damages submerged surfaces and raises greenhouse gas emissions. Biodegradable antifouling biocomposites were developed by hot‐mixing beeswax, Tween 80, and calcium stearate or stearic acid. Adjusting the component ratio enables processing via hot‐pressing, 3D‐printing, or dip‐coating.
Gabriele Corigliano, Lorenzo Ravelli, Martina Nardi, Ruowen Tu, Elena Bellini, Valerio Isa, Carlo Filippeschi, Roberta Finazzi, Luca Ceseracciu, Niloofar Paknezhad, Vincenzo Scribano, Paolo Galli, Silvia Lavorano, Simone Montano, Barbara Mazzolai, Marco Contardi, Pietro Cataldi, Athanassia Athanassiou   +17 more
wiley   +1 more source

Patch-clamp studies of macroscopic and single-channel currents in mouse neuroblastoma cells.

, 1988
Cells from the clonal cell line N1E115, a mouse tumour of sympathetic origin, differentiate both morphologically and electrophysiologically when cultured in medium containing dimethylsulphoxide.
Rosalind Anita Jane. Smith (7657352)
core   +4 more sources

Dendritic patch-clamp recording

, 2006
The patch−clamp technique allows investigation of the electrical excitability of neurons and the functional properties and densities of ion channels.
Davie, J., Ede A Rancz, Michael Häusser, Kole, M., Maarten H P Kole, Johannes J Letzkus, Häusser, M., Rancz, E., Letzkus, J., Greg J Stuart, Spruston, N., Nelson Spruston, Stuart, G., Jenny T Davie   +13 more
core   +1 more source

Intracrystalline Void‐Mediated Toughening of Brittle Crystals in Quail Eggshells

Advanced Functional Materials, EarlyView.
In quail eggshells, the high density and disordered arrangement of intracrystalline voids inhibit lattice cleavage, suppress long‐range crack propagation, and promote deformation twinning and quasi‐plasticity, serving as an essential toughening motif. We show that these voids remain within a narrow subcritical size range and therefore predominantly do ...
Jingxiao Zhong, Qihang Wang, Andre E. Vellwock, Sinuhe Perea Puente, Tingting Zhu, Jia Hui Lim, Kadda Medjoubi, Sebastian Hoerl, Erika Griesshaber, Wolfgang W. Schmahl, Yannicke Dauphin, Emeline Raguin, Peter Werner, Francesco Stellacci, Michael V. Swain, Peter Fratzl, Shahrouz Amini   +16 more
wiley   +1 more source

Assessing Transcriptome Quality in Patch-Seq Datasets

Frontiers in Molecular Neuroscience, 2018
Patch-seq, combining patch-clamp electrophysiology with single-cell RNA-sequencing (scRNAseq), enables unprecedented access to a neuron's transcriptomic, electrophysiological, and morphological features.
Shreejoy J. Tripathy, Shreejoy J. Tripathy, Lilah Toker, Lilah Toker, Claire Bomkamp, B. Ogan Mancarci, B. Ogan Mancarci, Manuel Belmadani, Manuel Belmadani, Paul Pavlidis, Paul Pavlidis   +10 more
doaj   +1 more source

Hydrogel‐Based Method for High‐Resolution Measurements of Contact Mechanics in Rapid Biological Adhesives: A Case Study in Cuttlefish Tentacle Strikes

Advanced Functional Materials, EarlyView.
Cuttlefish and squid can catch their prey within milliseconds using specialized tentacles and suckers. The physics of how the suckers can attach so quickly has remained a mystery given the technical challenges of studying them in vivo. In this publication, we develop a hydrogel that retains imprints of the suckers in order to estimate the forces they ...
Alexander Koehnsen, Mila F Krikke, Thomas E Kodger, Florian T Muijres, Guillermo J Amador   +4 more
wiley   +1 more source