Results 61 to 70 of about 800,201 (140)

Functional contribution of astrocytic Kir4.1 channels to spasticity after spinal cord injury

International audienceSpasticity, a prevalent motor issue characterized by network hyperexcitability, causes pain and discomfort, with existing treatments offering limited relief.
Ivanov, Anton, Ramirez-Franco, Jorge, Pecchi, Emilie, Brocard, Frédéric, Rouach, Nathalie, Bos, Rémi, Barbay, Tony   +6 more
core   +2 more sources

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice [PDF]

, 2014
Huntington's disease (HD) is characterized by striatal medium spiny neuron (MSN) dysfunction, but the underlying mechanisms remain unclear. We explored roles for astrocytes, in which mutant huntingtin is expressed in HD patients and mouse models.
Yan Ao, Faas, Guido C, Martin D Haustein, Sofroniew, Michael V, Istvan Mody, Nwaobi, Sinifunanya E, Khakh, Baljit S, Guido C Faas, Baljit S Khakh, Xiaoping Tong, Mark A Anderson, Tong, Xiaoping, Haustein, Martin D, Olsen, Michelle L, Anderson, Mark A, Sinifunanya E Nwaobi, Mody, Istvan, Ji Xu, Michelle L Olsen, Michael V Sofroniew, Ao, Yan, Xu, Ji   +21 more
core   +1 more source

Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells. [PDF]

, 2017
IF 5.168International audienceInwardly rectifying potassium channels (Kir), and especially the barium-sensitive Kir4.1 encoded by KCNJ10, are key regulators of glial functions. A lower expression or mislocation of Kir4.1 is detected in human brain tumors.
Chatelier, Aurelien, Gobbo, Jessica, Thuringer, Dominique, Bois, Patrick, Pernet, Nicolas, Nicolas Pernet, Eric Solary, Gaetan Jego, Carmen Garrido, Cronier, Laurent, Solary, Eric, Garrido, Carmen, Christophe Boudesco, Laurent Cronier, Gaetan Chanteloup, Dominique Thuringer, Jessica Gobbo, Boudesco, Christophe, Aurelien Chatelier, Jego, Gaetan, Patrick Bois, Boucher, Jonathan, Chanteloup, Gaetan, Jonathan Boucher   +23 more
core   +1 more source

Anti-Kir4.1 Antibodies in Multiple Sclerosis: Specificity and Pathogenicity

, 2020
The glial cells in the central nervous system express diverse inward rectifying potassium channels (Kir). They express multiple Kir channel subtypes that are likely to have distinct functional roles related to their differences in conductance, and ...
Mitsuharu Ueda, Michie Imamura, Akihiro Mukaino, Shunya Nakane, Yasuhiro Maeda, Hidenori Matsuo, Osamu Higuchi   +6 more
core   +1 more source

Type 2 diabetes disturbs Kir4.1 rhythm in retinal Müller cells

, 2016
poster abstractThe Müller cells function as a principal glia of the retina and maintain water homeostasis and K+ concentration via the specialized inwardly rectifying K+ (Kir) channels.
Luo, Qianyi, Bhatwadekar, Ashay
core   +1 more source

Role of astroglial Kir4.1 channels in the pathogenesis and treatment of epilepsy

Therapeutic Targets for Neurological Diseases, 2015
The inwardly rectifying potassium (Kir) channel subunit Kir4.1 is specifically expressed in brain astrocytes and Kir4.1-containing channels (Kir4.1 channels) mediate astroglial spatial potassium (K + ) buffering. Recent advances in Kir4.1 research revealed that Kir4.1 channels can serve as a novel therapeutic target for epilepsy.
openaire   +1 more source

Expressional analysis of the astrocytic Kir4.1 channel in a pilocarpine-induced temporal lobe epilepsy model

, 2013
The inwardly-rectifying potassium (Kir) channel Kir4.1 in brain astrocytes mediates spatial K+ buffering and regulates neural activities. Recent studies have shown that loss-of-function mutations in the human gene KCNJ10 encoding Kir4.1 cause epileptic ...
Yuki eNagao, Aoi Okuda, Saki eShimizu, Megumi eFujimoto, Yukihiro eOhno, Yuya Harada, Yoshihisa eSakagami, Aoi eOkuda, Takahiro Mukai, Takahiro eMukai, Asuka eOno, Yuki Nagao, Megumi Fujimoto, Asuka Ono, Saki Shimizu, Yukihiro Ohno, Yoshihisa Sakagami, Yuya eHarada   +17 more
core   +1 more source

Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region

, 2018
Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering.
Akio Ikeda, Yuki Nagao, Asuka Ono, Megumi Fujimoto, Masato Kinboshi, Saki Shimizu, Aoi Okuda, Yukihiro Ohno, Yoshihisa Sakagami, Hidefumi Ito, Takahiro Mukai   +10 more
core   +1 more source

Rôle des canaux astrocytaires spinaux Kir4.1 dans la douleur neuropathique

, 2022
La douleur neuropathique, qui résiste souvent aux analgésiques courants, représente un problème de santé majeur. Les mécanismes physiopathologiques de la douleur neuropathique sont multifactoriels et méconnus.
Makhoul, Jennifer
core  

In vitro and in silico characterization of the inhibition of Kir4.1 channels by aminoglycoside antibiotics. [PDF]

Br J Pharmacol, 2020
Morán-Zendejas R, Delgado-Ramírez M, Xu J, Valdés-Abadía B, Aréchiga-Figueroa IA, Cui M, Rodríguez-Menchaca AA.   +6 more
europepmc   +1 more source