Results 1 to 10 of about 5,036 (195)

Calcium Release from Stores Inhibits GIRK

Cell Reports, 2016
Synaptic transmission is mediated by ionotropic and metabotropic receptors that together regulate the rate and pattern of action potential firing. Metabotropic receptors can activate ion channels and modulate other receptors and channels.
Paul Kramer, John Williams
exaly   +6 more sources

Targeting GIRK Channels for the Development of New Therapeutic Agents [PDF]

Frontiers in Pharmacology, 2011
G protein-coupled inward rectifier K+ (GIRK) channels represent novel targets for the development of new therapeutic agents. GIRK channels are activated by a large number of G protein-coupled receptors (GPCRs) and regulate the electrical activity of ...
Kenneth Walsh
exaly   +7 more sources

GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders

Biomedicines, 2022
Substance use disorders (SUDs) are chronic, lifelong disorders that have serious consequences. Repeated substance use alters brain function. G-protein-activated inwardly rectifying potassium (GIRK) channels are expressed widely in the brain, including ...
Kazutaka Ikeda, Soichiro Ide
exaly   +4 more sources

Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels [PDF]

Frontiers in Physiology
Ion channels play a pivotal role in regulating cellular excitability and signal transduction processes. Among the various ion channels, G-protein-coupled inwardly rectifying potassium (GIRK) channels serve as key mediators of neurotransmission and ...
Paul Slesinger, Ian Glaaser
exaly   +4 more sources

Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor

Frontiers in Cellular Neuroscience, 2023
De novo mutations in GNB1, encoding the Gβ1 subunit of G proteins, cause a neurodevelopmental disorder with global developmental delay and epilepsy, GNB1 encephalopathy.
Nathan Dascal, Ryan Dhindsa, Amal Kanti Bera   +2 more
exaly   +5 more sources

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels [PDF]

Nature Communications
Gi/o protein-coupled receptors (GPCRs) inhibit cardiac and neuronal excitability via G protein-activated K+ channels (GIRK), assembled by combinations of GIRK1 - GIRK4 subunits.
Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Theres Friesacher, Galit Tabak, Vladimir Tsemakhovich, Haritha P. Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zuhlke, Carmen W. Dessauer, Enno Klussmann, Yoni Haitin, Joel A. Hirsch, Anna Stary-Weinzinger, Daniel Yakubovich, Nathan Dascal   +18 more
doaj   +3 more sources

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception [PDF]

Experimental Physiology
Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission.
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
doaj   +2 more sources

Membrane-associated estrogen receptor α prevents the amyloid β-induced suppression of GIRK channel activity in hippocampal neurons from female mice [PDF]

Biology of Sex Differences
Background Amyloid β oligomers (oAβ) are a key pathogenic driver in Alzheimer’s Disease (AD). Neuronal G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels are important regulators of neuronal excitability and prominent somatodendritic effectors ...
Haichang Luo, Ezequiel Marron Fernandez de Velasco, Jaeyoon Kim, Praseuth Yang, Paul Mermelstein, Joseph V. Bonventre, Paul S. Cooke, Kevin Wickman   +7 more
doaj   +2 more sources

Loss of expression and function of Gβγ by GNB1 encephalopathy-associated L95P mutation of the Gβ1 subunit [PDF]

Frontiers in Pharmacology
BackgroundG-proteins areindispensable regulators of cellular signaling, with G-protein-gated inwardly rectifying potassium channels (GIRK) as key effectors. GNB1 encephalopathy (GNB1E) is a congenital neurological syndrome resulting from mutations in the
Haritha P. Reddy, Tal Keren-Raifman, Galit Tabak, Nathan Dascal, Nathan Dascal, Daniel Yakubovich, Daniel Yakubovich   +6 more
doaj   +2 more sources

Reactivating the phototransduction cascade with a mutation agnostic gene therapy preserves vision in rod-cone dystrophies [PDF]

iScience
Summary: Rod-cone dystrophy (RCD) comprises genetic conditions where rod photoreceptor degeneration leads to cone loss, causing progressive vision loss.
Cardillia-Joe Simon, Hanen Khabou, Antoine Chaffiol, Marco Rucli, Marion Finzi, Nat Norberg, Anaïs Grimaud, Brix Mücher, Mélissa Desrosiers, Serge Sancho, Vera Lucia Bonilha, Kate Grieve, Jens Duebel, Michel Paques, Serge Picaud, José Alain Sahel, Isabelle Audo, Stefan Herlitze, Deniz Dalkara   +18 more
doaj   +2 more sources