Results 1 to 10 of about 3,632,036 (218)

BSA nanoparticles loaded with IONPs for biomedical applications: fabrication optimization, physicochemical characterization and biocompatibility evaluation [PDF]

Nanomedicine Journal, 2019
Objective(s): Cancer diagnosis in its early stages of progress, can enhance the efficiency of treatment utilizing conventional therapy methods. Non-biocompatibility of iron oxide nanoparticles (IONPs) has made a big challenge against their usage as a ...
Parvin Najafi, Hasan Kouchakzadeh
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Engineering, production, and immunogenicity studies of a truncated form of rabies virus glycoprotein produced in Nicotiana benthamiana plant

Medicine Science, 2022
Rabies is a viral disease caused by the rabies virus (Lyssavirus) that affects the central nervous system, ultimately leading to death and brain disease. Rabies usually transmitted through a bite among domestic dogs and wild carnivorous animals.
Gulshan Mammadova, Irem Gurbuzaslan, Damla Yuksel, Nilufer Gun, Nedim Mutlu, Gulnara Hasanova, Tarlan Mamedov   +6 more
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Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants

Disease Models & Mechanisms, 2022
Auriculocondylar syndrome 2 (ARCND2) is a rare autosomal dominant craniofacial malformation syndrome linked to multiple genetic variants in the coding sequence of phospholipase C β4 (PLCB4). PLCB4 is a direct signaling effector of the endothelin receptor
Stanley M. Kanai, Caleb Heffner, Timothy C. Cox, Michael L. Cunningham, Francisco A. Perez, Aaron M. Bauer, Philip Reigan, Cristan Carter, Stephen A. Murray, David E. Clouthier   +9 more
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Structure-Guided Designing and Evaluation of Peptides Targeting Bacterial Transcription

Frontiers in Bioengineering and Biotechnology, 2020
The mycobacterial RNA polymerase (RNAP) is an essential and validated drug target for developing antibacterial drugs. The β-subunit of Mycobacterium tuberculosis (Mtb) RNAP (RpoB) interacts with an essential and global transcription factor, CarD, and ...
Gundeep Kaur, Srajan Kapoor, Soni Kaundal, Dipak Dutta, Krishan Gopal Thakur   +4 more
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The Evolution of Intein-Based Affinity Methods as Reflected in 30 years of Patent History

Frontiers in Molecular Biosciences, 2022
Self-cleaving affinity tags, based on engineered intein protein domains, have been touted as a universal single step purification platform for tagless non-mAb proteins.
Sai Vivek Prabhala, Izabela Gierach, David W. Wood, David W. Wood   +3 more
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Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

eLife, 2020
The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets.
Eric M Jones, Nathan B Lubock, AJ Venkatakrishnan, Jeffrey Wang, Alex M Tseng, Joseph M Paggi, Naomi R Latorraca, Daniel Cancilla, Megan Satyadi, Jessica E Davis, M Madan Babu, Ron O Dror, Sriram Kosuri   +12 more
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Structural comparison of unconventional G protein YchF with heterotrimeric G protein and small G protein

Plant Signaling & Behavior, 2022
Guanine nucleotide-binding (G) proteins, namely, phosphate-binding (P) loop GTPases, play a critical role in life processes among different species. Based on the structural characteristics, G proteins can be divided into heterotrimeric G proteins, small ...
Maozhen Luo, Zhiwei Han, Guoye Huang, Rongfang Li, Yi Liu, Junjie Lu, Lin Liu, Rui Miao   +7 more
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Neonatal priming and infancy boosting with a novel respiratory syncytial virus vaccine induces protective immune responses without concomitant respiratory disease upon RSV challenge

Human Vaccines & Immunotherapeutics, 2020
Although respiratory syncytial virus (RSV) infection in infants and young children is a global public health issue, development of a safe RSV vaccine has been impeded by formalin-inactivated RSV-enhanced respiratory disease (ERD).
Shuren Zhang, Gan Zhao, Caixia Su, Chaofan Li, Xian Zhou, Weidong Zhao, Yiwei Zhong, Zhonghuai He, Haichang Peng, Aihua Dong, Bin Wang   +10 more
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Structure Elucidation and Biochemical Characterization of Environmentally Relevant Novel Extradiol Dioxygenases Discovered by a Functional Metagenomics Approach

mSystems, 2019
The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu, Vipul Solanki, Anil Kumar Pinnaka, Krishan Gopal Thakur   +3 more
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Strain-Dependent Impact of G and SH Deletions Provide New Insights for Live-Attenuated HMPV Vaccine Development

Vaccines, 2019
Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and ...
Julia Dubois, Andrés Pizzorno, Marie-Hélène Cavanagh, Blandine Padey, Claire Nicolas de Lamballerie, Olus Uyar, Marie-Christine Venable, Julie Carbonneau, Aurélien Traversier, Thomas Julien, Sophie Lavigne, Christian Couture, Bruno Lina, Marie-Ève Hamelin, Olivier Terrier, Manuel Rosa-Calatrava, Guy Boivin   +16 more
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