Results 11 to 20 of about 5,912,842 (308)

Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]

, 2018
More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian, Caro, Lydia N, Dror, Ron O, Ernst, Oliver P, Hollingsworth, Scott A, Hubbell, Wayne L, Latorraca, Naomi R, Van Eps, Ned   +7 more
core   +1 more source

Structure Elucidation and Biochemical Characterization of Environmentally Relevant Novel Extradiol Dioxygenases Discovered by a Functional Metagenomics Approach

mSystems, 2019
The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu, Vipul Solanki, Anil Kumar Pinnaka, Krishan Gopal Thakur   +3 more
doaj   +3 more sources

Neonatal priming and infancy boosting with a novel respiratory syncytial virus vaccine induces protective immune responses without concomitant respiratory disease upon RSV challenge

Human Vaccines & Immunotherapeutics, 2020
Although respiratory syncytial virus (RSV) infection in infants and young children is a global public health issue, development of a safe RSV vaccine has been impeded by formalin-inactivated RSV-enhanced respiratory disease (ERD).
Shuren Zhang, Gan Zhao, Caixia Su, Chaofan Li, Xian Zhou, Weidong Zhao, Yiwei Zhong, Zhonghuai He, Haichang Peng, Aihua Dong, Bin Wang   +10 more
doaj   +1 more source

Dual positive and negative regulation of GPCR signaling by GTP hydrolysis [PDF]

, 2009
G protein-coupled receptors (GPCRs) regulate a variety of intracellular pathways through their ability to promote the binding of GTP to heterotrimeric G proteins. Regulator of G protein signaling (RGS) proteins increase the intrinsic GTPase activity of G-
Berg, Hugo van den, Davey, John, Godfrey, Emma L., Hill, Claire, Hodgkin, Matthew N., Ladds, Graham, Rand, D. A., Smith, Benjamin, Thornton, Steven   +8 more
core   +1 more source

Determination of Energy and Protein Requirements of Sheep in Indonesia Using a Meta-analytical Approach [PDF]

, 2017
The objective of this study was to determine energy and protein requirements, for both maintenance and gain, of sheep in Indonesia by using a meta-analysis method.
Astuti, D. A. (D), Jayanegara, A. (A), Laconi, E. B. (E), Nahrowi, N. (Nahrowi), Ridla, M. (M), Wiryawan, K. G. (K)   +5 more
core   +3 more sources

Strain-Dependent Impact of G and SH Deletions Provide New Insights for Live-Attenuated HMPV Vaccine Development

Vaccines, 2019
Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and ...
Julia Dubois, Andrés Pizzorno, Marie-Hélène Cavanagh, Blandine Padey, Claire Nicolas de Lamballerie, Olus Uyar, Marie-Christine Venable, Julie Carbonneau, Aurélien Traversier, Thomas Julien, Sophie Lavigne, Christian Couture, Bruno Lina, Marie-Ève Hamelin, Olivier Terrier, Manuel Rosa-Calatrava, Guy Boivin   +16 more
doaj   +1 more source

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

eLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee   +8 more
doaj   +1 more source

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]

, 2017
Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have
Baillie, George S., Blanco, Francisco J., Blanco-Canosa, Juan B., Cerione, Richard A., de la Cruz-Morcillo, Miguel Angel, DiGiacomo, Vincent, Garcia-Marcos, Mikel, Ibáñez de Opakua, Alain, Leyme, Anthony, Marivin, Arthur, Merino, Nekane, Nguyen, Lien T., Parag-Sharma, Kshitij, Ramachandran, Sekar, Villate, Maider   +14 more
core   +1 more source

The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders [PDF]

Frontiers in Pharmacology, 2018
Progress toward new antidepressant therapies has been relatively slow over the past few decades, with the result that individuals suffering from depression often struggle to find an effective treatment - a process often requiring months. Furthermore, the neural factors that contribute to depression remain poorly understood, and there are many open ...
Nicolas B. Senese, Nicolas B. Senese, Nicolas B. Senese, Mark M. Rasenick, Mark M. Rasenick, Mark M. Rasenick, John R. Traynor   +6 more
openaire   +3 more sources

ARTD10/PARP10 Induces ADP-Ribosylation of GAPDH and Recruits GAPDH into Cytosolic Membrane-Free Cell Bodies When Overexpressed in Mammalian Cells

Challenges, 2018
Protein ADP-ribosylation is a reversible post-translational modification of cellular proteins that is catalysed by enzymes that transfer one (mono) or several (poly) units of ADP-ribose from β-NAD+ to a specific amino acid of the target protein. The
Emilia Mayo, Gaia Fabrizio, Emanuele Salvatore Scarpa, Annalisa Stilla, Nadia Dani, Fulvio Chiacchiera, Henning Kleine, Francesca Attanasio, Bernhard Lüscher, Maria Di Girolamo   +9 more
doaj   +1 more source