Results 11 to 20 of about 3,632,036 (218)

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

eLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee   +8 more
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Isolation and Taxonomic Characterization of Novel Haloarchaeal Isolates From Indian Solar Saltern: A Brief Review on Distribution of Bacteriorhodopsins and V-Type ATPases in Haloarchaea

Frontiers in Microbiology, 2020
Haloarchaea inhabit high salinity environments worldwide. They are a potentially rich source of crucial biomolecules like carotenoids and industrially useful proteins.
Dipesh Kumar Verma, Chetna Chaudhary, Latika Singh, Chandni Sidhu, Busi Siddhardha, Senthil E. Prasad, Krishan Gopal Thakur   +6 more
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Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

MedComm, 2022
GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear ...
Fang Ye, Thian‐Sze Wong, Geng Chen, Zhiyi Zhang, Binghao Zhang, Shiyi Gan, Wei Gao, Jiancheng Li, Zhangsong Wu, Xin Pan, Yang Du   +10 more
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MAPKs in development: insights from Dictyostelium signaling pathways

Biomolecular Concepts, 2011
Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals.
Hadwiger Jeffrey A., Nguyen Hoai-Nghia
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GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species

Vascular Biology, 2019
The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm.
Raafat Mohamed, Reearna Janke, Wanru Guo, Yingnan Cao, Ying Zhou, Wenhua Zheng, Hossein Babaahmadi-Rezaei, Suowen Xu, Danielle Kamato, Peter J Little   +9 more
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Binding characteristics of staphylococcal protein A and streptococcal protein G for fragment crystallizable portion of human immunoglobulin G

Computational and Structural Biotechnology Journal, 2021
In the wide array of physiological processes, protein–protein interactions and their binding are the most basal activities for achieving adequate biological metabolism.
Hae Gon Lee, Shinill Kang, Joon Sang Lee
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REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors

Biosensors, 2023
Despite G protein-coupled receptors (GPCRs) being important theapeutic targets, the signaling properties of many GPCRs remain poorly characterized. GPCR activation primarily initiates heterotrimeric G protein signaling. To detect ligand-induced G protein
Katrijn Boon, Nathan Vanalken, Eef Meyen, Dominique Schols, Tom Van Loy   +4 more
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ARTD10/PARP10 Induces ADP-Ribosylation of GAPDH and Recruits GAPDH into Cytosolic Membrane-Free Cell Bodies When Overexpressed in Mammalian Cells

Challenges, 2018
Protein ADP-ribosylation is a reversible post-translational modification of cellular proteins that is catalysed by enzymes that transfer one (mono) or several (poly) units of ADP-ribose from β-NAD+ to a specific amino acid of the target protein. The
Emilia Mayo, Gaia Fabrizio, Emanuele Salvatore Scarpa, Annalisa Stilla, Nadia Dani, Fulvio Chiacchiera, Henning Kleine, Francesca Attanasio, Bernhard Lüscher, Maria Di Girolamo   +9 more
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Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast

Biomolecules, 2022
The yeast Saccharomyces cerevisiae has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about the receptors and signaling pathways that indicate glucose availability.
Shuang Li, Yuanyuan Li, Blake R. Rushing, Sarah E. Harris, Susan L. McRitchie, Daniel Dominguez, Susan J. Sumner, Henrik G. Dohlman   +7 more
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Electrospun Nanofibers and their Application in Tissue Repair and Engineering

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: Tissue engineering is the repair and replacement of damaged tissues and requires a combination of cells, growth factor and porous scaffolds.
Sareh Arjmand, Alireza Partovi Baghdadeh, Amin Hamidi, Seyed Omid Ranaei Siadat   +3 more
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