Results 21 to 30 of about 5,912,842 (308)

Isolation and Taxonomic Characterization of Novel Haloarchaeal Isolates From Indian Solar Saltern: A Brief Review on Distribution of Bacteriorhodopsins and V-Type ATPases in Haloarchaea

Frontiers in Microbiology, 2020
Haloarchaea inhabit high salinity environments worldwide. They are a potentially rich source of crucial biomolecules like carotenoids and industrially useful proteins.
Dipesh Kumar Verma, Chetna Chaudhary, Latika Singh, Chandni Sidhu, Busi Siddhardha, Senthil E. Prasad, Krishan Gopal Thakur   +6 more
doaj   +1 more source

G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35 [PDF]

, 2017
It is widely appreciated that G protein-coupled receptors have been the most successfully exploited class of targets for the development of small molecule medicines. Despite this, to date, less than 15% of the non-olfactory G protein-coupled receptors in
Milligan, Graeme
core   +1 more source

Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

MedComm, 2022
GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear ...
Fang Ye, Thian‐Sze Wong, Geng Chen, Zhiyi Zhang, Binghao Zhang, Shiyi Gan, Wei Gao, Jiancheng Li, Zhangsong Wu, Xin Pan, Yang Du   +10 more
doaj   +1 more source

MAPKs in development: insights from Dictyostelium signaling pathways

Biomolecular Concepts, 2011
Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals.
Hadwiger Jeffrey A., Nguyen Hoai-Nghia
doaj   +1 more source

Binding characteristics of staphylococcal protein A and streptococcal protein G for fragment crystallizable portion of human immunoglobulin G

Computational and Structural Biotechnology Journal, 2021
In the wide array of physiological processes, protein–protein interactions and their binding are the most basal activities for achieving adequate biological metabolism.
Hae Gon Lee, Shinill Kang, Joon Sang Lee
doaj   +1 more source

Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes [PDF]

, 1993
Injection of rat atrial RNA into Xenopus oocytes resulted in the expression of a guanine nucleotide binding (G) protein-activated K+ channel. Current through the channel could be activated by acetylcholine or, if RNA encoding a neuronal 5HT1A receptor ...
Dascal, Nathan, Davidson, Norman, Lester, Henry A., Lim, Nancy F., Schreibmayer, Wolfgang, Wang, Weizhen   +5 more
core   +1 more source

GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species

Vascular Biology, 2019
The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm.
Raafat Mohamed, Reearna Janke, Wanru Guo, Yingnan Cao, Ying Zhou, Wenhua Zheng, Hossein Babaahmadi-Rezaei, Suowen Xu, Danielle Kamato, Peter J Little   +9 more
doaj   +1 more source

REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors

Biosensors, 2023
Despite G protein-coupled receptors (GPCRs) being important theapeutic targets, the signaling properties of many GPCRs remain poorly characterized. GPCR activation primarily initiates heterotrimeric G protein signaling. To detect ligand-induced G protein
Katrijn Boon, Nathan Vanalken, Eef Meyen, Dominique Schols, Tom Van Loy   +4 more
doaj   +1 more source

Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast

Biomolecules, 2022
The yeast Saccharomyces cerevisiae has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about the receptors and signaling pathways that indicate glucose availability.
Shuang Li, Yuanyuan Li, Blake R. Rushing, Sarah E. Harris, Susan L. McRitchie, Daniel Dominguez, Susan J. Sumner, Henrik G. Dohlman   +7 more
doaj   +1 more source

Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans [PDF]

, 1991
A cDNA corresponding to a known G protein alpha subunit, the alpha subunit of Go (Go alpha), was isolated and sequenced. The predicted amino acid sequence of C. elegans Go alpha is 80-87% identical to other Go alpha sequences.
Lochrie, Michael A., Mendel, Jane E., Simon, Melvin I., Sternberg, Paul W.   +3 more
core   +1 more source