Results 21 to 30 of about 3,592,901 (265)

Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast

open access: yesBiomolecules, 2022
The yeast Saccharomyces cerevisiae has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about the receptors and signaling pathways that indicate glucose availability.
Shuang Li   +7 more
doaj   +1 more source

Watching G proteins at work [PDF]

open access: yesTrends in Neurosciences, 1990
It has been known for over a century that rod photoreceptors in the living retina contract and swell in response to light. Although it is still not known whether this structural light-response is of any functional significance, it has recently been possible to correlate the underlying molecular processes with the activation and deactivation of the ...
Uhl, R., Wagner, R., Ryba, N.
openaire   +4 more sources

Electrospun Nanofibers and their Application in Tissue Repair and Engineering

open access: yesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: Tissue engineering is the repair and replacement of damaged tissues and requires a combination of cells, growth factor and porous scaffolds.
Sareh Arjmand   +3 more
doaj  

The G protein γ subunit SlGGC1 regulates saline-alkali stress response in tomato

open access: yesVegetable Research
Saline-alkali stress poses a severe threat to crop yield and quality. While significant progress has been achieved in elucidating the mechanisms of plant resistance to salt stress, the molecular underpinnings governing plant responses to saline-alkali ...
Yanru Zhang   +10 more
doaj   +1 more source

Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

open access: yesScientific Reports, 2018
CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex.
Gundeep Kaur   +5 more
doaj   +1 more source

Heterotrimeric G-Protein Signalers and RGSs in Aspergillus fumigatus

open access: yesPathogens, 2020
The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various
Hee-Soo Park   +3 more
doaj   +1 more source

The Disruption of a Gα Subunit Sheds New Light on the Pathogenicity of Stagonospora nodorum on Wheat

open access: yesMolecular Plant-Microbe Interactions, 2004
Gna1, a gene encoding a Gα subunit, a key component of signal transduction pathways, has been cloned and characterized in the wheat pathogen Stagonospora nodorum.
Peter S. Solomon   +4 more
doaj   +1 more source

DEER Analysis of GPCR Conformational Heterogeneity

open access: yesBiomolecules, 2021
G protein-coupled receptors (GPCRs) represent a large class of transmembrane helical proteins which are involved in numerous physiological signaling pathways and therefore represent crucial pharmacological targets.
Matthias Elgeti, Wayne L. Hubbell
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

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