Results 31 to 40 of about 5,036 (195)

Expression of GIRK (Kir3.1/Kir3.4) channels in mouse fibroblast cells with and without β1 integrins [PDF]

, 2000
G protein‐activated K⁺ channel (GIRK) subunits possess a conserved extracellular integrin‐binding motif (RGD) and bind directly to β1 integrins. We expressed GIRK1/GIRK4 channels labeled with green fluorescent protein in fibroblast cell lines expressing ...
Neusch, Clemens, Labarca, Cesar, Lester, Henry A., Ivanina, Tatiana, Li, Yong-Xin, Mosher, Deane F., Tong, Yanhe   +6 more
core   +2 more sources

Molecular basis of signaling specificity between GIRK channels and GPCRs

eLife, 2018
Stimulated muscarinic acetylcholine receptors (M2Rs) release Gβγ subunits, which slow heart rate by activating a G protein-gated K+ channel (GIRK). Stimulated β2 adrenergic receptors (β2ARs) also release Gβγ subunits, but GIRK is not activated.
Kouki K Touhara, Roderick MacKinnon
doaj   +1 more source

Discovery, characterization and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.X and Kir7.1

Frontiers in Pharmacology, 2011
The inward rectifier family of potassium (Kir) channels is comprised of at least 16 family members exhibiting broad and often overlapping cellular, tissue or organ distributions.
Jerod S Denton
doaj   +1 more source

Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. [PDF]

PLoS ONE, 2013
G protein-gated inwardly rectifying potassium (GIRK) channels play an important role in regulating neuronal excitability. Sorting nexin 27b (SNX27b), which reduces surface expression of GIRK channels through a PDZ domain interaction, contains a putative ...
Bartosz Balana, Laia Bahima, Karthik Bodhinathan, Jaume J Taura, Natalie M Taylor, Margaret Y Nettleton, Francisco Ciruela, Paul A Slesinger   +7 more
doaj   +1 more source

Inhibition of G Protein-Activated Inwardly Rectifying K+ Channels by the Antidepressant Paroxetine

Journal of Pharmacological Sciences, 2006
Paroxetine is commonly used as a selective serotonin reuptake inhibitor for the treatment of depression and other psychiatric disorders. However, the molecular mechanisms of the paroxetine effects have not yet been sufficiently clarified.
Toru Kobayashi, Kazuo Washiyama, Kazutaka Ikeda   +2 more
doaj   +1 more source

Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons. [PDF]

PLoS ONE, 2011
We recently demonstrated, in rat brain slices, that the usual excitation by noradrenaline (NA) of hypocretin/orexin (hcrt/orx) neurons was changed to an inhibition following sleep deprivation (SD).
Aaron Uschakov, Jeremy Grivel, Vesna Cvetkovic-Lopes, Laurence Bayer, Laurent Bernheim, Barbara E Jones, Michel Mühlethaler, Mauro Serafin   +7 more
doaj   +1 more source

AsKC11, a Kunitz Peptide from Anemonia sulcata, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels

Marine Drugs, 2022
(1) Background: G protein-coupled inward-rectifier potassium (GIRK) channels, especially neuronal GIRK1/2 channels, have been the focus of intense research interest for developing drugs against brain diseases.
Dongchen An, Ernesto Lopes Pinheiro-Junior, László Béress, Irina Gladkikh, Elena Leychenko, Eivind A. B. Undheim, Steve Peigneur, Jan Tytgat   +7 more
doaj   +1 more source

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Nature Communications, 2019
Opening of G protein-gated inwardly rectifying potassium channels (GIRK) is coupled to the activation of a GPCR. Here the authors use NMR and cell-based BRET assays to gain insights into the mechanisms underlying family-specific activation and find that ...
Hanaho Kano, Yuki Toyama, Shunsuke Imai, Yuta Iwahashi, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Ichio Shimada   +7 more
doaj   +1 more source

GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells

, 2020
How G protein-coupled receptors (GPCRs) evoke specific biological outcomes while utilizing a limited array of G proteins and effectors is poorly understood, particularly in native cell systems.
Birnbaumer, L., Anderson, Allison, Wickman, K., Birnbaumer, Lutz, Masuho, Ikuo, Nakano, Atsushi, Martemyanov, K.A., Martemyanov, Kirill A., Marron Fernandez de Velasco, Ezequiel, Wickman, Kevin, Masuho, I., Nakano, A., De Velasco, E.M.F., Anderson, A.   +13 more
core   +1 more source

Modeling GIRK channel conductance [PDF]

Journal of General Physiology, 2019
JGP study uses MD simulations to investigate the gating and conductance of the inwardly rectifying potassium channel GIRK2.
openaire   +2 more sources