Results 51 to 60 of about 5,036 (195)
Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
The Journal of Physiology, EarlyView.Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone +1 more
wiley +1 more source
Regulators of neuronal GIRK channels [PDF]
, 2008 Balancing inhibitory and excitatory inputs is essential for proper signaling in the brain. A significant component of inhibition involves the G protein-gated inwardly rectifying potassium (GIRK/Kir3) channels. GIRK channels have been shown to play a role
Nassirpour, Rounak
core
Reduced GABA-B/GIRK-mediated regulation of the VTA following a single exposure to cocaine [PDF]
, 2012 In this paper, Arora and colleagues expand on their previous work on GIRK channels in the ventral tegmental area (VTA) presenting evidence that a single exposure to cocaine reduces inhibitory GABAergic transmission to dopamine (DA) neurons in the ventral
Donald C. Cooper +2 more
core +1 more source
Frontiers in Physiology, 2014 Alcohol (ethanol)-induced behaviors arise from direct interaction of alcohol with discrete protein cavities within brain proteins. Recent structural and biochemical studies have provided new insights into the mechanism of alcohol-dependent activation of ...
Karthik eBodhinathan, Paul A Slesinger
doaj +1 more source
Mechanism of PKCε regulation of cardiac GIRK channel gating
Proceedings of the National Academy of Sciences, 2022 G-protein-gated inwardly rectifying potassium (GIRK) channel activity is regulated by the membrane phospholipid, phosphatidylinositol-4,5-bisphosphate (PI 4,5P 2 ). Constitutive activity of cardiac GIRK channels in atrial myocytes, that is implicated in atrial fibrillation (AF), is mediated ...
Kirin D. Gada +5 more
openaire +2 more sources
Insights into mechanism of alcohol mediated modulation of GIRK channels [PDF]
, 2010 Ion channels are proteins that control the flow of ions in and out of the cell. They are important in many aspects of human physiology such as muscle contraction, sensory perception, thought and behavior.
Aryal, Prafulla
core
Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity
, 2014 G-protein-coupled inwardly rectifying potassium (GIRK) channels contribute to the resting membrane potential of many neurons, including dopamine (DA) neurons in the ventral tegmental area (VTA).
Tan, Kelly R. +9 more
core +1 more source
Protein expression of G-protein inwardly rectifying potassium channels (GIRK) in breast cancer cells [PDF]
, 2006 Background Previous data from our laboratory has indicated that a functional link exists between the G-protein-coupled inwardly rectifying potassium (GIRK) channel and the beta-adrenergic receptor pathway in breast cancer cell lines, and these pathways ...
Dhar, Madhu S. +3 more
core +1 more source
Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells
Frontiers in Cellular Neuroscience, 2022 Activin A, a member of the TGF-β family, is recognized as a multifunctional protein in the adult brain with a particular impact on neuronal circuits associated with cognitive and affective functions.
Fang Zheng +3 more
doaj +1 more source
A Fluorescent Screening Assay for Identifying Modulators of GIRK Channels [PDF]
Journal of Visualized Experiments, 2012 G protein-gated inward rectifier K+ (GIRK) channels function as cellular mediators of a wide range of hormones and neurotransmitters and are expressed in the brain, heart, skeletal muscle and endocrine tissue(1,2). GIRK channels become activated following the binding of ligands (neurotransmitters, hormones, drugs, etc.) to their plasma membrane-bound ...
Maribel, Vazquez +2 more
openaire +2 more sources