Results 71 to 80 of about 5,036 (195)

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

Frontiers in Pharmacology, 2023
The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction.
Viktor Burström, Richard Ågren, Nibal Betari, Marta Valle-León, Marta Valle-León, Emilio Garro-Martínez, Francisco Ciruela, Francisco Ciruela, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm   +11 more
doaj   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Repeated Cocaine Weakens GABAB-Girk Signaling in Layer 5/6 Pyramidal Neurons in the Prelimbic Cortex [PDF]

, 2013
SummaryRepeated cocaine exposure triggers adaptations in layer 5/6 glutamatergic neurons in the medial prefrontal cortex (mPFC) that promote behavioral sensitization and drug-seeking behavior.
Hearing, Matthew, Marron Fernandez de Velasco, Ezequiel, Wickman, Kevin, Fajardo-Serrano, Ana, Luján, Rafael, Kotecki, Lydia, Chung, Hee Jung   +6 more
core   +1 more source

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

The Journal of Physiology, Volume 604, Issue 17, Page 7313-7336, 1 September 2026.
Abstract figure legend Prader‐Willi syndrome (PWS) originates from deficiencies in chromosome 15q11‐13 region clustering around a critical region containing multiple‐repeat non‐coding RNA gene Snord116, resulting in metabolic and behavioural abnormalities leading to hyperphagia and obesity.
Volodymyr Rybalchenko, Ryan Butler
wiley   +1 more source

GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin [PDF]

The Journal of Neuroscience, 2015
Melatonin supplementation has been used as a therapeutic agent for several diseases, yet little is known about the underlying mechanisms by which melatonin synchronizes circadian rhythms. G-protein signaling plays a large role in melatonin-induced phase shifts of locomotor behavior and melatonin receptors activate G-protein-coupled inwardly rectifying ...
Lauren M. Hablitz, Hylton E. Molzof, Kathryn E. Abrahamsson, Joanna M. Cooper, Rebecca A. Prosser, Karen L. Gamble   +5 more
openaire   +2 more sources

Hippocampal long‐range GABAergic neurons target hippocampal‐projecting cells of the supramammillary area

The Journal of Physiology, Volume 604, Issue 18, Page 7924-7956, 15 September 2026.
Abstract figure legend The hippocampus contains a diversity of inhibitory neurons, including somatostatin‐expressing (SST+) and neuronal nitric oxide synthase‐expressing (NOS+) projection neurons that target extrahippocampal brain regions, including the hypothalamic supramammillary area (SuM).
Lauren Glassburn, Edmund Havener, Olivia Stangler, Ezequiel Marron Fernandez de Velasco, Esther Krook‐Magnuson   +4 more
wiley   +1 more source

GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner [PDF]

, 2015
G-protein-gated inwardly rectifying K (GIRK/Kir3) channel activation underlies key physiological effects of opioids, including analge-sia and dependence.
Weaver, C. David, Slesinger, PA, McCall, Nora M., Xia, Z, Wickman, K, de Velasco, Ezequiel Marron Fernandez, Slesinger, Paul A., Arora, D, Victoria, Nicole C., McCall, NM, Victoria, NC, Arora, Devinder, Hearing, M, de Velasco, EMF, Hearing, Matthew, Pravetoni, Marco, Munoz, Michaelanne B., Wickman, Kevin, Pravetoni, M, Kotecki, Lydia, Munoz, MB, Xia, Zhilian, Kotecki, L, Weaver, CD   +23 more
core   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins

, 2008
Regulator of G-protein signaling (RGS) proteins are strong modulators of G-protein-mediated pathways in the nervous system. One function of RGS proteins is to accelerate the activation-deactivation kinetics of G-protein-coupled inwardly rectifying ...
Luescher, Christian, Lomazzi, Marta, Slesinger, Paul A.   +2 more
core   +1 more source

Exercise, Demethylase FTO, Neurological Disorders, and Neuropathic Pain: Potential Molecular Mechanisms

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
This review summarizes the role of FTO‐regulated m6A modification in Alzheimer's disease, Parkinson's disease, depression, and neuropathic pain. Exercise may ameliorate neural plasticity and neuronal excitability by downregulating FTO and enhancing m6A modification. We propose that FTO could serve as a potential epigenetic target through which exercise
Yanan Zheng, Yili Zheng, Peijie Chen, Xueqiang Wang   +3 more
wiley   +1 more source