Results 1 to 10 of about 26,558 (201)
Biomolecules, 2023 Metazoan cell nuclei contain non-membrane pools of the phosphoinositide lipid PI(4,5)P2 (PIP2), but how this hydrophobic lipid exists within the aqueous nucleoplasm remains unclear.
Ethan S. Chi +2 more
doaj +3 more sources
Dual Regulation of Voltage-Sensitive Ion Channels by PIP2
Frontiers in Pharmacology, 2012 Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2). Among them are voltage-gated channels, which are crucial
Aldo A Rodríguez-Menchaca +2 more
exaly +3 more sources
Small Nucleolar RNA from S. cerevisiae Binds to Phosphatidylinositol 4,5-Bisphosphate [PDF]
Non-Coding RNABackground: snoRNAs have traditionally been known for their role as guides in post-transcriptional rRNA modifications. Previously, our research group identified several RNAs that may bind to PIP2 with LIPRNA-seq.
Irma A. Jiménez-Ramírez +3 more
doaj +2 more sources
Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2
Computational and Structural Biotechnology Journal, 2014 We have shown earlier that Kir2 channels are suppressed by the elevation of membrane cholesterol. Moreover, it is also well known that activation of Kir channels is critically dependent on a regulatory phospholipid, phosphatidylinositol-4,5-bisphosphate (
yulia Epshtein, Irena Levitan
exaly +3 more sources
Optogenetic Control of PIP2 Interactions Shaping ENaC Activity
International Journal of Molecular Sciences, 2022 The activity of the epithelial Na+ Channel (ENaC) is strongly dependent on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 binds two distinct cationic clusters within the N termini of β- and γ-ENaC subunits (βN1 and γN2). The affinities of these sites were previously determined using short synthetic peptides, yet their role
Tarek Mohamed Abd El Aziz +2 more
exaly +3 more sources
Cells adapt to extracellular acidic pH through TM9SF3-mediated PI(4,5)P2 flop [PDF]
Nature CommunicationsThe plasma membrane (PM), a physical barrier separating cells from their environment, responds to fluctuating extracellular environment through receptor-mediated signaling. While these pathways have been extensively studied, the role of PM lipids remains
Keisuke Sako +11 more
doaj +2 more sources
Cell Reports, 2018 Summary: Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms ...
Wang Zheng, Ruiqi Cai, Wentong Long
exaly +3 more sources
CD9‐association with PIP2 areas is regulated by a CD9 salt bridge [PDF]
FEBS Open BioTetraspanins are membrane proteins involved in multiple cellular functions, which they regulate by means of tetraspanin‐enriched microdomains. While many tetraspanin‐associated processes are regulated by intracellular signaling, possibly through the ...
Yahya Homsi +2 more
doaj +2 more sources
Neuron, 2007 The function of inwardly rectifying K+ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al. recognize a conserved structural mechanism for Kir channels gating by both pH and PIP2.
Guy-David, Liora, Reuveny, Eitan
openaire +2 more sources
PIP2, An Auxin Induced Plant Peptide Hormone Regulates Root and Hypocotyl Elongation in Arabidopsis
Frontiers in Plant Science, 2021 Auxin is one of the traditional plant hormones, whereas peptide hormones are peptides with hormone activities. Both auxin and plant peptide hormones regulate multiple aspects of plant growth and development, and there are cross-talks between auxin and ...
Saddam Hussain +15 more
doaj +1 more source