Results 1 to 10 of about 31,206 (230)

SF-1 Induces Nuclear PIP2

Biomolecules, 2023
Metazoan cell nuclei contain non-membrane pools of the phosphoinositide lipid PI(4,5)P2 (PIP2), but how this hydrophobic lipid exists within the aqueous nucleoplasm remains unclear.
Ethan S. Chi, Elizabeth A. Stivison, Raymond D. Blind   +2 more
doaj   +4 more sources

Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2 [PDF]

Computational and Structural Biotechnology Journal, 2014
We have shown earlier that Kir2 channels are suppressed by the elevation of membrane cholesterol. Moreover, it is also well known that activation of Kir channels is critically dependent on a regulatory phospholipid, phosphatidylinositol-4,5-bisphosphate (
yulia Epshtein, Irena Levitan, Avia Rosenhouse-Dantsker   +2 more
exaly   +4 more sources

PIP2 activation of the cardiac IKs potassium channel [PDF]

Nature Communications
The IKs channel, composed of voltage-gated potassium channel KCNQ1 and regulatory subunit KCNE1, controls cardiac action potential durations. KCNQ1 and IKs activation requires PIP2, and its depletion abolishes channel opening.
Lu Zhao, Xianjin Xu, Chenxi Cui, Rui Duan, Ali A. Kermani, Jingyi Shi, Lu Han, Ji Sun, Xiaoqin Zou, Jianmin Cui   +9 more
doaj   +2 more sources

PIP2, An Auxin Induced Plant Peptide Hormone Regulates Root and Hypocotyl Elongation in Arabidopsis

Frontiers in Plant Science, 2021
Auxin is one of the traditional plant hormones, whereas peptide hormones are peptides with hormone activities. Both auxin and plant peptide hormones regulate multiple aspects of plant growth and development, and there are cross-talks between auxin and ...
Saddam Hussain, Saddam Hussain, Wei Wang, Sajjad Ahmed, Xutong Wang, Adnan, Yuxin Cheng, Chen Wang, Yating Wang, Na Zhang, Hainan Tian, Siyu Chen, Xiaojun Hu, Tianya Wang, Shucai Wang, Shucai Wang   +15 more
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ATP competes with PIP2 for binding to gelsolin. [PDF]

PLoS ONE, 2018
Gelsolin is a severing and capping protein that targets filamentous actin and regulates filament lengths near plasma membranes, contributing to cell movement and plasma membrane morphology. Gelsolin binds to the plasma membrane via phosphatidylinositol 4,
Dávid Szatmári, Bo Xue, Balakrishnan Kannan, Leslie D Burtnick, Beáta Bugyi, Miklós Nyitrai, Robert C Robinson   +6 more
doaj   +1 more source

Molecular basis of the PIP2-dependent regulation of CaV2.2 channel and its modulation by CaV β subunits

eLife, 2022
High-voltage-activated Ca2+ (CaV) channels that adjust Ca2+ influx upon membrane depolarization are differentially regulated by phosphatidylinositol 4,5-bisphosphate (PIP2) in an auxiliary CaV β subunit-dependent manner.
Cheon-Gyu Park, Wookyung Yu, Byung-Chang Suh   +2 more
doaj   +1 more source

Long-term depression in neurons involves temporal and ultra-structural dynamics of phosphatidylinositol-4,5-bisphosphate relying on PIP5K, PTEN and PLC

Communications Biology, 2023
Ultrahigh-resolution views of PIP2 in freeze-fractured plasma membranes of dendritic spines during induction of long-term depression reveal spatial and temporal cues set by PIP2 and reveal the molecular mechanisms behind the observed PIP2 ...
Sarah A. Hofbrucker-MacKenzie, Eric Seemann, Martin Westermann, Britta Qualmann, Michael M. Kessels   +4 more
doaj   +1 more source

Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure

Frontiers in Physiology, 2021
BIN1 (amphyphysin-II) is a structural protein involved in T-tubule (TT) formation and phosphatidylinositol-4,5-bisphosphate (PIP2) is responsible for localization of BIN1 to sarcolemma.
Junlan Zhou, Neha Singh, Chloe Monnier, William Marszalec, Li Gao, Jing Jin, Michael Frisk, Michael Frisk, William E. Louch, William E. Louch, Suresh Verma, Prasanna Krishnamurthy, Elsa Nico, Maaz Mulla, Gary L. Aistrup, Raj Kishore, J. Andrew Wasserstrom   +16 more
doaj   +1 more source

PIP2 determines length and stability of primary cilia by balancing membrane turnovers

Communications Biology, 2022
By using methods to synthesise or degrade PIP2 selectively in the ciliary membrane, Stilling et al. find that PIP2 levels determine the length of primary cilia.
Simon Stilling, Theodoros Kalliakoudas, Hannah Benninghoven-Frey, Takanari Inoue, Björn H Falkenburger   +4 more
doaj   +1 more source

Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation

Scientific Reports, 2022
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) regulates the activities of numerous membrane proteins, including diacylglycerol(DAG)-activated TRPC3/6/7 channels.
Masayuki X. Mori, Ryo Okada, Reiko Sakaguchi, Hideharu Hase, Yuko Imai, Onur K. Polat, Satoru G. Itoh, Hisashi Okumura, Yasuo Mori, Yasushi Okamura, Ryuji Inoue   +10 more
doaj   +1 more source