Results 11 to 20 of about 31,206 (230)
Neuron, 2007 The function of inwardly rectifying K+ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al.
Guy-David, Liora, Reuveny, Eitan
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Dual Regulation of Voltage-Sensitive Ion Channels by PIP2 [PDF]
Frontiers in Pharmacology, 2012 Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2). Among them are voltage-gated channels, which are crucial
Aldo A Rodríguez Menchaca +3 more
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Interaction of the MARCKS peptide with PIP2 in phospholipid monolayers [PDF]
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009 In this present work we have studied the effect of MARCKS (151-175) peptide on a mixed DPPC/PIP2 monolayer. By means of film balance, fluorescence microscopy, x-ray reflection/diffraction and neutron reflection measurements we detected changes in the ...
Käs, J.A. +7 more
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Charge Shielding of PIP2 by Cations Regulates Enzyme Activity of Phospholipase C. [PDF]
PLoS ONE, 2015 Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) of the plasma membrane by phospholipase C (PLC) generates two critical second messengers, inositol-1,4,5-trisphosphate and diacylglycerol.
Jong Bae Seo +4 more
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The multifaceted role of PIP2 in leukocyte biology
Cellular and Molecular Life Sciences, 2015 Phosphatidylinositol 4,5-bisphosphate (PIP2) represents about 1 % of plasma membrane phospholipids and behaves as a pleiotropic regulator of a striking number of fundamental cellular processes.
Ricciarda Galandrini +9 more
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PIP2-induced membrane binding of the Vinculin tail competes with its other binding partners.
, 2021 Vinculin plays a key role during the first phase of focal adhesion formation and interacts with the plasma membrane through specific binding of its Tail domain to the lipid phosphatidylinositol 4,5-bisphosphate (PIP2).
Lukas Braun (1498408) +2 more
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Autoinhibition of TRPV6 Channel and Regulation by PIP2 [PDF]
iScience, 2020 Transient receptor potential vanilloid 6 (TRPV6), a calcium-selective channel possessing six transmembrane domains (S1-S6) and intracellular N and C termini, plays crucial roles in calcium absorption in epithelia and bone and is involved in human diseases including vitamin-D deficiency, osteoporosis, and cancer. The TRPV6 function and regulation remain
Ruiqi Cai +13 more
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CO2 Transport by PIP2 Aquaporins of Barley [PDF]
Plant and Cell Physiology, 2014 CO2 permeability of plasma membrane intrinsic protein 2 (PIP2) aquaporins of Hordeum vulgare L. was investigated. Five PIP2 members were heterologously expressed in Xenopus laevis oocytes. CO2 permeability was determined by decrease of cytosolic pH in CO2-enriched buffer using a hydrogen ion-selective microelectrode.
Mori, Izumi C. +6 more
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Divalent Cation-Induced PIP2 Clustering in Cholesterol-Containing Membranes: How PIP2 Lateral Distribution affects PIP2-Gelsolin Interaction [PDF]
Biophysical Journal, 2013 Phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2) is involved in many important cellular events, but the mechanism by which this relatively rare lipid selectively regulates specific proteins is unclear. While many proteins bind to PIP2 with similar affinities in vitro, only a small subset interact with PIP2 at specific sites during specific cellular ...
Wang, Yu-Hsiu, Janmey, Paul A.
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Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]
, 2008 The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N. +5 more
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