Results 11 to 20 of about 26,558 (201)
ATP competes with PIP2 for binding to gelsolin. [PDF]
PLoS ONE, 2018 Gelsolin is a severing and capping protein that targets filamentous actin and regulates filament lengths near plasma membranes, contributing to cell movement and plasma membrane morphology. Gelsolin binds to the plasma membrane via phosphatidylinositol 4,
Dávid Szatmári +6 more
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eLife, 2022 High-voltage-activated Ca2+ (CaV) channels that adjust Ca2+ influx upon membrane depolarization are differentially regulated by phosphatidylinositol 4,5-bisphosphate (PIP2) in an auxiliary CaV β subunit-dependent manner.
Cheon-Gyu Park +2 more
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Divalent Cation-Induced PIP2 Clustering in Cholesterol-Containing Membranes: How PIP2 Lateral Distribution affects PIP2-Gelsolin Interaction [PDF]
Biophysical Journal, 2013 Phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2) is involved in many important cellular events, but the mechanism by which this relatively rare lipid selectively regulates specific proteins is unclear. While many proteins bind to PIP2 with similar affinities in vitro, only a small subset interact with PIP2 at specific sites during specific cellular ...
Wang, Yu-Hsiu, Janmey, Paul A.
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Frontiers in Physiology, 2021 BIN1 (amphyphysin-II) is a structural protein involved in T-tubule (TT) formation and phosphatidylinositol-4,5-bisphosphate (PIP2) is responsible for localization of BIN1 to sarcolemma.
Junlan Zhou +16 more
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Communications Biology, 2023 Ultrahigh-resolution views of PIP2 in freeze-fractured plasma membranes of dendritic spines during induction of long-term depression reveal spatial and temporal cues set by PIP2 and reveal the molecular mechanisms behind the observed PIP2 ...
Sarah A. Hofbrucker-MacKenzie +4 more
doaj +1 more source
PIP2 Reshapes Membranes through Asymmetric Desorption [PDF]
Biophysical Journal, 2019 Phosphatidylinositol-4,5-bisphosphate (PIP2) is an important signaling lipid in eukaryotic cell plasma membranes, playing an essential role in diverse cellular processes. The headgroup of PIP2 is highly negatively charged, and this lipid displays a high critical micellar concentration compared to housekeeping phospholipid analogs.
Sankalp Shukla +4 more
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Autoinhibition of TRPV6 Channel and Regulation by PIP2 [PDF]
iScience, 2020 Transient receptor potential vanilloid 6 (TRPV6), a calcium-selective channel possessing six transmembrane domains (S1-S6) and intracellular N and C termini, plays crucial roles in calcium absorption in epithelia and bone and is involved in human diseases including vitamin-D deficiency, osteoporosis, and cancer. The TRPV6 function and regulation remain
Ruiqi Cai +13 more
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PIP2 determines length and stability of primary cilia by balancing membrane turnovers
Communications Biology, 2022 By using methods to synthesise or degrade PIP2 selectively in the ciliary membrane, Stilling et al. find that PIP2 levels determine the length of primary cilia.
Simon Stilling +4 more
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TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Charge Shielding of PIP2 by Cations Regulates Enzyme Activity of Phospholipase C.
PLoS ONE, 2015 Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) of the plasma membrane by phospholipase C (PLC) generates two critical second messengers, inositol-1,4,5-trisphosphate and diacylglycerol.
Jong Bae Seo +4 more
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