Results 21 to 30 of about 26,558 (201)
Scientific Reports, 2022 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) regulates the activities of numerous membrane proteins, including diacylglycerol(DAG)-activated TRPC3/6/7 channels.
Masayuki X. Mori +10 more
doaj +1 more source
Voltage-Sensitive PIP2 Phosphatase Shows PIP2 Requirements for KCNQ and Ca2+ Channels [PDF]
Biophysical Journal, 2011 The four talks in this symposium highlight the dependence of ion channel function on membrane phospholipids and fatty acids. Although of low abundance (1-2%), the phosphoinositide phosphatidylinositol 4,5-bisphosphate (PIP2) is a signature lipid of plasma membranes.
Hille, Bertil +4 more
openaire +1 more source
CO2 Transport by PIP2 Aquaporins of Barley [PDF]
Plant and Cell Physiology, 2014 CO2 permeability of plasma membrane intrinsic protein 2 (PIP2) aquaporins of Hordeum vulgare L. was investigated. Five PIP2 members were heterologously expressed in Xenopus laevis oocytes. CO2 permeability was determined by decrease of cytosolic pH in CO2-enriched buffer using a hydrogen ion-selective microelectrode.
Mori, Izumi C. +6 more
openaire +2 more sources
PLoS Genetics, 2015 Multiple PIP2 dependent molecular processes including receptor activated phospholipase C activity occur at the neuronal plasma membranes, yet levels of this lipid at the plasma membrane are remarkably stable.
Purbani Chakrabarti +6 more
doaj +1 more source
Cell Communication and Signaling, 2023 Background The Hippo pathway plays a critical role in controlled cell proliferation. The tumor suppressor Merlin and large tumor suppressor kinase 1 (LATS1) mediate activation of Hippo pathway, consequently inhibiting the primary effectors, Yes ...
Truc Phan Hoang Le +4 more
doaj +1 more source
Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
Exploration of Neuroprotective Therapy, 2021 Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeostasis of phosphatidylinositol 4,5-bisphosphate (PIP2 ...
Kamran Tariq, Bryan W. Luikart
doaj +1 more source
PIP2 PIP2 Hooray for Maxi K+ [PDF]
The Journal of General Physiology, 2008 Voltage-gated K+ (KV) channels contain a voltage-sensing transmembrane segment that moves in response to changes in membrane potential. A small “gating” current arises from the translocation of positively charged residues within the channel's voltage sensor.
openaire +3 more sources
Synthetic Manipulation of PIP2 Levels and PIP2-Associated Chemotactic Signaling Dissection in Dictyostelium [PDF]
Biophysical Journal, 2015 Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown involved in key chemotactic signaling pathways in Dictyostelium, but our understanding of its roles in this signaling network is very limited. To explore the hypothesis that PIP2 negatively regulate chemotactic signaling events, we used the Chemically-induced Dimerization system, which allows ...
Miao, Yuchuan +2 more
openaire +1 more source
The biphasic increase of PIP2 in the fertilized eggs of starfish: new roles in actin polymerization and Ca2+ signaling. [PDF]
PLoS ONE, 2010 BACKGROUND: Fertilization of echinoderm eggs is accompanied by dynamic changes of the actin cytoskeleton and by a drastic increase of cytosolic Ca(2+). Since the plasma membrane-enriched phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) serves as
Jong T Chun +5 more
doaj +1 more source
eLife, 2014 GIRK channels control spike frequency in atrial pacemaker cells and inhibitory potentials in neurons. By directly responding to G proteins, PIP2 and Na+, GIRK is under the control of multiple signaling pathways. In this study, the mammalian GIRK2 channel
Weiwei Wang +2 more
doaj +1 more source