Results 21 to 30 of about 31,206 (230)
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes [PDF]
, 2009 In the present study the effect of phosphatidylinositol 4,5-bisphosphate (PIP2) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit portal vein myocytes.
Saleh, Sohag N. +5 more
core +1 more source
To B or Not to B: PIP2 Answers the Question [PDF]
Developmental Cell, 2005 In a recent issue of Molecular Cell, Papayannopoulos et al. (2005) show that N-WASP activation of actin-related protein2/3 (Arp2/3) is ultrasensitive to PI(4,5)P(2) concentration. We discuss how interactions between basic regions in proteins and negatively charged membranes can produce sharp on-off switches that may regulate biological activity.
Murray, Diana, Honig, Barry
openaire +2 more sources
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
PLoS Genetics, 2015 Multiple PIP2 dependent molecular processes including receptor activated phospholipase C activity occur at the neuronal plasma membranes, yet levels of this lipid at the plasma membrane are remarkably stable.
Purbani Chakrabarti +6 more
doaj +1 more source
Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]
, 2009 We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert +8 more
core +1 more source
Cell Communication and Signaling, 2023 Background The Hippo pathway plays a critical role in controlled cell proliferation. The tumor suppressor Merlin and large tumor suppressor kinase 1 (LATS1) mediate activation of Hippo pathway, consequently inhibiting the primary effectors, Yes ...
Truc Phan Hoang Le +4 more
doaj +1 more source
Science-Business eXchange, 2014 A UNC Chapel Hill team has found a way to block multiple pain receptors by antagonizing the lipid kinase PIP5K1C. Although a PIP5K1C inhibitor alleviates chronic pain in multiple mouse models, the lethality of PIP5K1C mutations suggests that titrating the right dose will be key for safety.
openaire +1 more source
The biphasic increase of PIP2 in the fertilized eggs of starfish: new roles in actin polymerization and Ca2+ signaling. [PDF]
PLoS ONE, 2010 BACKGROUND: Fertilization of echinoderm eggs is accompanied by dynamic changes of the actin cytoskeleton and by a drastic increase of cytosolic Ca(2+). Since the plasma membrane-enriched phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) serves as
Jong T Chun +5 more
doaj +1 more source
Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
Exploration of Neuroprotective Therapy, 2021 Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeostasis of phosphatidylinositol 4,5-bisphosphate (PIP2 ...
Kamran Tariq, Bryan W. Luikart
doaj +1 more source
PIP2 PIP2 Hooray for Maxi K+ [PDF]
The Journal of General Physiology, 2008 Voltage-gated K+ (KV) channels contain a voltage-sensing transmembrane segment that moves in response to changes in membrane potential. A small “gating” current arises from the translocation of positively charged residues within the channel's voltage sensor.
openaire +3 more sources