Results 31 to 40 of about 31,206 (230)
Voltage-Sensitive PIP2 Phosphatase Shows PIP2 Requirements for KCNQ and Ca2+ Channels [PDF]
Biophysical Journal, 2011 The four talks in this symposium highlight the dependence of ion channel function on membrane phospholipids and fatty acids. Although of low abundance (1-2%), the phosphoinositide phosphatidylinositol 4,5-bisphosphate (PIP2) is a signature lipid of plasma membranes.
Hille, Bertil +4 more
openaire +1 more source
Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity [PDF]
, 2011 TRPM6 is crucial for human Mg2+ homeostasis as patients carrying TRPM6 mutations develop hypomagnesemia and secondary hypocalcemia (HSH). However, the activation mechanism of TRPM6 has remained unknown. Here we demonstrate that phosphatidylinositol-4,
Xie, Jia +4 more
core +3 more sources
Synthetic Manipulation of PIP2 Levels and PIP2-Associated Chemotactic Signaling Dissection in Dictyostelium [PDF]
Biophysical Journal, 2015 Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown involved in key chemotactic signaling pathways in Dictyostelium, but our understanding of its roles in this signaling network is very limited. To explore the hypothesis that PIP2 negatively regulate chemotactic signaling events, we used the Chemically-induced Dimerization system, which allows ...
Miao, Yuchuan +2 more
openaire +1 more source
PIP2-dependent formation of CD44-FERM complex.
, 2020 (A) Presentation of CD44-FERM conformation and association on the membrane surface in the presence of PIP2. The backbone structure of CD44 is shown in blue, the FERM domain is shown in different shades of yellow/green, dependent on the subdomain.
Carlos R. Palacios (8694648) +5 more
core +1 more source
Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels
eLife, 2020 G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP2. Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP2 concentration.
Yiming Niu +3 more
doaj +1 more source
, 2022 Atomistic and Coarse Grained simulaitions of GCGR in simple and complex bilayers studying the interaction with PIP2 lipids.
openaire +2 more sources
Frontiers in Immunology, 2018 The toll/interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) plays an important role in the toll-like receptor (TLR) 2, TLR4, TLR7, and TLR9 signaling pathways.
Mahesh Chandra Patra, Sangdun Choi
doaj +1 more source
A Molecular Dynamics Investigation of Lipid Bilayer Perturbation by PIP2 [PDF]
, 2010 Phosphoinositides like phosphatidylinositol 4,5-bisphosphate (PIP2) are negatively charged lipids that play a pivotal role in membrane trafficking, signal transduction, and protein anchoring.
Lupyan, Dmitry +3 more
core +1 more source
eLife, 2014 GIRK channels control spike frequency in atrial pacemaker cells and inhibitory potentials in neurons. By directly responding to G proteins, PIP2 and Na+, GIRK is under the control of multiple signaling pathways. In this study, the mammalian GIRK2 channel
Weiwei Wang +2 more
doaj +1 more source
Integrative binding sites within intracellular termini of TRPV1 receptor. [PDF]
PLoS ONE, 2012 TRPV1 is a nonselective cation channel that integrates wide range of painful stimuli. It has been shown that its activity could be modulated by intracellular ligands PIP2 or calmodulin (CaM).
Lenka Grycova +6 more
doaj +1 more source