Results 31 to 40 of about 26,558 (201)

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels

eLife, 2020
G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP2. Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP2 concentration.
Yiming Niu, Xiao Tao, Kouki K Touhara, Roderick MacKinnon   +3 more
doaj   +1 more source

A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.

PLoS ONE, 2014
IntroductionPhosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2.
Fabien C Coyan, Fayal Abderemane-Ali, Mohamed Yassine Amarouch, Julien Piron, Jérôme Mordel, Céline S Nicolas, Marja Steenman, Jean Mérot, Céline Marionneau, Annick Thomas, Robert Brasseur, Isabelle Baró, Gildas Loussouarn   +12 more
doaj   +1 more source

Integrative binding sites within intracellular termini of TRPV1 receptor. [PDF]

PLoS ONE, 2012
TRPV1 is a nonselective cation channel that integrates wide range of painful stimuli. It has been shown that its activity could be modulated by intracellular ligands PIP2 or calmodulin (CaM).
Lenka Grycova, Blanka Holendova, Ladislav Bumba, Jan Bily, Michaela Jirku, Zdenek Lansky, Jan Teisinger   +6 more
doaj   +1 more source

Insight into Phosphatidylinositol-Dependent Membrane Localization of the Innate Immune Adaptor Protein Toll/Interleukin 1 Receptor Domain-Containing Adaptor Protein

Frontiers in Immunology, 2018
The toll/interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) plays an important role in the toll-like receptor (TLR) 2, TLR4, TLR7, and TLR9 signaling pathways.
Mahesh Chandra Patra, Sangdun Choi
doaj   +1 more source

GCGR-PIP2

, 2022
Atomistic and Coarse Grained simulaitions of GCGR in simple and complex bilayers studying the interaction with PIP2 lipids.
openaire   +1 more source

The pain of PIP2 [PDF]

Science-Business eXchange, 2014
A UNC Chapel Hill team has found a way to block multiple pain receptors by antagonizing the lipid kinase PIP5K1C. Although a PIP5K1C inhibitor alleviates chronic pain in multiple mouse models, the lethality of PIP5K1C mutations suggests that titrating the right dose will be key for safety.
openaire   +1 more source

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome

Cells, 2021
Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear ...
Martin Sztacho, Barbora Šalovská, Jakub Červenka, Can Balaban, Peter Hoboth, Pavel Hozák   +5 more
doaj   +1 more source

Molecular Basis of Pip2 Gating KirBac1.1 [PDF]

Biophysical Journal, 2012
KirBac1.1 is a bacterial inward rectifier potassium (Kir) channel, which, in contrast to its eukaryotic homologues, is strongly inhibited by phosphatidylinositol-4,5-bisphosphate (PIP2). Previously, we labeled introduced cysteines in the KirBac1.1 cytoplasmic domain with small molecule fluorophores to examine PIP2 dependent structural rearrangements by
Wang, Shizhen, Heyman, Sarah, Enkvetchakul, Decha, Nichols, Colin G.   +3 more
openaire   +1 more source

Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Trichomonas vaginalis

mBio
Trichomonas vaginalis is the etiologic agent of trichomoniasis, one of the most common non-viral sexually transmitted infections globally. Our previous work reported the role of phosphatidylinositol 4,5-bisphosphates (PIP2) signaling in the actin ...
Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu   +3 more
doaj   +1 more source

GCGR PIP2 interaction data nMS

, 2022
Native Mass Spectra of GCGR and phospholipids, POPS, POPA, POPG, and PI(4,5)P2.
Yan, Jun, Sørensen, Lars
openaire   +1 more source