Results 41 to 50 of about 31,206 (230)

Ion Channel Modulation by Photocaged Dioctanoyl PIP2 [PDF]

, 2009
Phosphatidylinositol bisphosphate (PIP2) directly regulates electrophysiological activity in a diverse family of ion channels whether the effect is stimulatory or inhibitory.
Ha, Junghoon
core   +1 more source

A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.

PLoS ONE, 2014
IntroductionPhosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2.
Fabien C Coyan, Fayal Abderemane-Ali, Mohamed Yassine Amarouch, Julien Piron, Jérôme Mordel, Céline S Nicolas, Marja Steenman, Jean Mérot, Céline Marionneau, Annick Thomas, Robert Brasseur, Isabelle Baró, Gildas Loussouarn   +12 more
doaj   +1 more source

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome

Cells, 2021
Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear ...
Martin Sztacho, Barbora Šalovská, Jakub Červenka, Can Balaban, Peter Hoboth, Pavel Hozák   +5 more
doaj   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Specifics of PIP2 in CD44 binding.

, 2020
(A) A snapshot of the CD44-Pal-295 in binding PIP2 molecules and the frequency distribution of the involved residues binding the CT domain. The side chains of KKK300 are shown in cyan.
Carlos R. Palacios (8694648), Lida Xu (326852), Carsten F. E. Schroer (7429250), Fude Sun (1577581), Siewert J. Marrink (135518), Shi-Zhong Luo (620108)   +5 more
core   +1 more source

Effect of PIP2 on vesicles release in neural cells

, 2021
Lipids serve numerous different processes in biological cell communication. As for the case ofPhosphatidylinositol‐(4,5)‐biphosphate (PIP2), which serves actin‐dynamics, endocytosis, and ofrecent importance, exocytosis.
Wahlund, Jonathan
core   +2 more sources

Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2

Nature Communications, 2023
BTR1 (SLC4A11) is a NH3 stimulated H+ (OH-) transporter belonging to the SLC4 family. Dysfunction of BTR1 leads to diseases such as congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy (FECD).
Yishuo Lu, Peng Zuo, Hongyi Chen, Hui Shan, Weize Wang, Zonglin Dai, He Xu, Yayu Chen, Ling Liang, Dian Ding, Yan Jin, Yuxin Yin   +11 more
doaj   +1 more source

Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Trichomonas vaginalis

mBio
Trichomonas vaginalis is the etiologic agent of trichomoniasis, one of the most common non-viral sexually transmitted infections globally. Our previous work reported the role of phosphatidylinositol 4,5-bisphosphates (PIP2) signaling in the actin ...
Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu   +3 more
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Alterations in Conserved Kir Channel-PIP2 Interactions Underlie Channelopathies [PDF]

, 2002
Inwardly rectifying K+ (Kir) channels are important regulators of resting membrane potential and cell excitability. The activity of Kir channels is critically dependent on the integrity of channel interactions with phosphatidylinositol 4,5-bisphosphate ...
Lopes, Coeli M.B., Jin, Taihao, Rohacs, Tibor, Yang, Jian, Logothetis, Diomedes E., Zhang, Hailin   +5 more
core   +1 more source