Results 81 to 90 of about 5,036 (195)
RGS proteins maintain robustness of GPCR‐GIRK coupling [PDF]
The FASEB Journal, 2012 Objective To elucidate the mechanism underlying sustained GPCR‐GIRK coupling under RGS actions. Results Regulators of G‐protein signaling (RGS) are GTPase activating proteins (GAP) that reduce response amplitudes of activated G‐protein
Chuang, Huai-hu, Chuang, Alexander Y.
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Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO) [PDF]
, 2016 G-protein coupled inwardly rectifying potassium (GIRK) channels are expressed throughout the human body and are an integral part of inhibitory signal transduction pathways. Upon binding of G(beta gamma) subunits released from G-protein coupled receptors (
Barber, D. +15 more
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Alzheimer’s Research & Therapy, 2022 Alzheimer’s disease (AD) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity.
Alejandro Martín-Belmonte +10 more
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Addiction Biology, Volume 31, Issue 7, July 2026.Chronic intravenous long‐access fentanyl self‐administration in rats produced transcriptional remodeling in the habenula and amygdala. Bulk RNA‐sequencing identified 453 habenula and 3,041 amygdala differentially expressed genes, revealing upregulation of synaptic process and ionic conductance genes in habenula, upregulation of metabolic and vesicular ...
Robin Magnard +8 more
wiley +1 more source
Elucidation of the gating of the GIRK channel using a spectroscopic approach [PDF]
The Journal of Physiology, 2009 The traditional view of G protein‐coupled receptor (GPCR)‐mediated signalling puts the players in this signalling cascade, namely the GPCR, the G protein and its effector, as individual components in space, where the signalling specificity is obtained mainly by the interaction of the GPCR and the Gα subunits of the G protein.
Adi, Raveh, Inbal, Riven, Eitan, Reuveny
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Scientific Reports, 2017 Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron’s membrane potential, providing an important component of inhibition in the brain.
Ian W. Glaaser, Paul A. Slesinger
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou +7 more
wiley +1 more source
Modulation of Neuronal GIRK Channels by Cholesterol
The FASEB Journal, 2015 In recent years, cholesterol emerged as a major regulator of ion channel function. The most common effect of cholesterol on ion channels is a decrease in channel activity. We have recently shown that unexpectedly cholesterol enrichment up‐regulates G‐protein gated inwardly rectifying potassium (GIRK or Kir3) currents in atrial ...
Avia Rosenhouse‐Dantsker, Anna Bukiya
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Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
Physiological contribution and molecular details of GIRK-dependent signaling in the heart
, 2020 University of Minnesota Ph.D. dissertation. July 2020. Major: Pharmacology. Advisor: Kevin Wickman. 1 computer file (PDF); vii, 182 pages.Activation of parasympathetic signaling to the heart results in a slowing of heart rate (HR) and an increase in ...
Anderson, Allison
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