Results 101 to 110 of about 5,036 (195)
Psychostimulant-induced plasticity of GIRK channel signaling in ventral tegmental area / [PDF]
, 2013 Natural rewards and addictive drugs increase the release of dopamine (DA) in the brain's reward circuit by augmenting the activity of dopaminergic neurons in the ventral tegmental area (VTA).
Munoz, Michaelanne Berry
core +1 more source
eLife, 2016 Experiments on artificial membranes are revealing many details about the workings of a family of potassium ion channels called GIRK channels.
Christopher Miller
doaj +1 more source
, 2023 Mutations in the KCNJ5 gene, encoding one of the major subunits of cardiac G-protein-gated inwardly rectifying K+ (GIRK) channels, have been recently linked to inherited forms of sinus node dysfunction.
Arie O. Verkerk +5 more
core +1 more source
Gαi Controls the Gating of the G Protein-Activated K+ Channel, GIRK [PDF]
, 2002 GIRK (Kir3) channels are activated by neurotransmitters coupled to G proteins, via a direct binding of Gβγ. The role of Gα subunits in GIRK gating is elusive. Here we demonstrate that Gαi is not only a donor of Gβγ but also regulates GIRK gating.
Dascal, Nathan +4 more
core +1 more source
Molecules and Cells: It is well known that the G protein-gated inwardly rectifying K+ (GIRK) channels are critical to maintain excitability of central neurons. GIRK channels consist of 4 subunits and GIRK1/GIRK2 heterotetramers are considered to be the neuronal prototype ...
Yeeun Choi +3 more
doaj +1 more source
, 2013 G protein-coupled inwardly rectifying K+ channels (GIRK) are important in the regulation of heart rate and atrial electrophysiology. GIRK channels are activated by G protein-coupled receptors, including muscarinic M2 receptors and adenosine A1 receptors.
Olesen, Søren-Peter +5 more
core +1 more source
Journal of Pharmacological Sciences, 2014 .: G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several Gi/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of ...
Daisuke Nishizawa +10 more
doaj +1 more source
PLoS Computational Biology, 2015 G protein-gated K+ channels (GIRK; Kir3), activated by Gβγ subunits derived from Gi/o proteins, regulate heartbeat and neuronal excitability and plasticity.
Daniel Yakubovich +8 more
doaj +1 more source
Modulation of the rectification properties of GIRK channels by G Protein subunits
, 2008 G-Protein-gekoppelte einwärtsgleichrichtende Kalium-Kanäle sind durch zwei Eigenschaften gekennzeichnet: (I) Die Leitfähigkeit für K+-Ionen ist positiv des Kalium-Gleichgewichtspotentials reduziert und (II) die Kanal-Aktivität wird durch Bindung von G ...
Hommers, Leif
core +2 more sources