Results 121 to 130 of about 5,036 (195)

Dysfunction in Ankyrin-B Disrupts Heart Rate Regulation by Altering the Membrane Abundance of GIRK Channels. [PDF]

JACC Basic Transl Sci
Li J, Kline CF, Cavus O, Bobik JT, Malhotra N, Raghavan J, Takenaka SS, Kwak J, Cordeiro RJ, Mohler EJ, Dudley E, Xu X, Nassal DM, Wu Y, Hund TJ, Mangoni ME, Mohler PJ, El Refaey M.   +17 more
europepmc   +1 more source

Molecular pharmacology of mGlu_7/8 heterodimers reveals unique properties of orthosteric agonists and positive allosteric modulators. [PDF]

Mol Pharmacol
Ferranti AS, Noh Y, Lei X, Lin X, Bungard JD, Asher WB, Javitch JA, Niswender CM.   +7 more
europepmc   +1 more source

Discovery of VU6052959/BI'7927: A Selective mGlu₃ Positive Allosteric Modulator (PAM) from an Orthogonal Benzoxazine Chemotype. [PDF]

ACS Med Chem Lett
Jones CA, Duncan RA, Gilliland KM, Haymer DH, Spearing PK, Capstick RA, Roland BP, Vinson P, Quitalig M, Baggeroer C, Billard NB, Dickerson JW, Watson KJ, Kramlinger VM, Boutaud O, Ursu D, Wotjak CT, Priepke H, Garneau M, Trenz K, Niswender CM, Cho HP, Rook JM, Freiwald M, Giovannini R, Sommer H, Hobson S, Conn PJ, Melancon BJ, Lindsley CW, Reed CW.   +30 more
europepmc   +1 more source

Discovery of VU6053371/BI03738809: A First-in-Class Selective and CNS-Penetrant mGlu₃ Positive Allosteric Modulator (PAM) with Efficacy in a Preclinical Cognition Model. [PDF]

ACS Chem Neurosci
Jones CA, Duncan RA, Gilliland KM, Reed CW, Haymer DH, Spearing PK, Capstick RA, Roland BP, Vinson P, Quitalig M, Baggeroer C, Billard NB, Dickerson JW, Xiang Z, Kramlinger VM, Boutaud O, Schlichtiger J, Jones CK, Niswender CM, Cho HP, Rook JL, Wotjak CT, Freiwald M, Giovannini R, Sommer H, Hobson S, Conn PJ, Melancon BJ, Lindsley CW.   +28 more
europepmc   +1 more source

Biomolecular assemblies through weak noncovalent interactions: Higher-order transient structures and their condensate phase. [PDF]

Proc Natl Acad Sci U S A
MacKinnon R, Haselwandter CA.
europepmc   +1 more source

Dynamics of synchronous bursts in functionally coupled midbrain dopamine neurons driven by diverse excitatory inputs. [PDF]

Front Syst Neurosci
Chen MJ.
europepmc   +1 more source

Receptor-specific regulation of the supraventricular G-protein-activated inwardly rectifying potassium channel (GIRK) by protein kinase C isoforms

Die Aktivierung supraventrikulärer GIRK-Kanäle ist ein wichtiger Mechanismus der parasympathischen Regulation der Herzfrequenz und der kardialen Erregbarkeit. GIRK-Kanäle werden im Zuge der Aktivierung von muskarinergen M\(_2\)-Rezeptoren durch G\(_{i/o}\
Inderwiedenstraße, Leonie (Dr. rer. nat.)
core   +1 more source

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity. [PDF]

Elife
Toyoda H, Kim D, Koh BG, Sano T, Kanematsu T, Oh SB, Kang Y.   +6 more
europepmc   +1 more source

A critical residue mediates proper assembly and gating of GIRK2 channels. [PDF]

J Gen Physiol
Nguyen H, Mount J, Hutchinson K, Zhao Y, Zhao Y, Glaaser IW, Yuan P, Schlessinger A, Slesinger PA.   +8 more
europepmc   +1 more source

Heavy adolescent drinking makes the adult brain more vulnerable to ethanol by permanently altering the age-dependent interplay between alcohol, GIRK channels and activin. [PDF]

Mol Psychiatry
Stürzenberger S, Bülow N, Kalinichenko LS, Licha R, Eulenburg V, Dahlmanns M, Müller CP, Zheng F, Alzheimer C.   +8 more
europepmc   +1 more source