Results 41 to 50 of about 5,036 (195)

New insights into the therapeutic potential of Girk channels [PDF]

Trends in Neurosciences, 2014
G protein-dependent signaling pathways control the activity of excitable cells of the nervous system and heart, and are the targets of neurotransmitters, clinically relevant drugs, and drugs of abuse. G protein-gated inwardly rectifying potassium (K(+)) (Girk/Kir3) channels are a key effector in inhibitory signaling pathways.
Rafael, Luján, Ezequiel, Marron Fernandez de Velasco, Carolina, Aguado, Kevin, Wickman   +3 more
openaire   +2 more sources

Structural insights into GIRK2 channel modulation by cholesterol and PIP2

Cell Reports, 2021
Summary: G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with ...
Yamuna Kalyani Mathiharan, Ian W. Glaaser, Yulin Zhao, Michael J. Robertson, Georgios Skiniotis, Paul A. Slesinger   +5 more
doaj   +1 more source

A discrete alcohol pocket involved in GIRK channel activation [PDF]

Nature Neuroscience, 2009
Ethanol modifies neural activity in the brain by modulating ion channels. Ethanol activates G protein-gated inwardly rectifying K(+) channels, but the molecular mechanism is not well understood. Here, we used a crystal structure of a mouse inward rectifier containing a bound alcohol and structure-based mutagenesis to probe a putative alcohol-binding ...
Aryal, Prafulla, Dvir, Hay, Choe, Senyon, Slesinger, Paul A.   +3 more
openaire   +2 more sources

Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels

Journal of Lipid Research, 2019
Cholesterol, a critical component of the cellular plasma membrane, is essential for normal neuronal function. Cholesterol content is highest in the brain, where most cholesterol is synthesized de novo; HMG-CoA reductase controls the synthesis rate ...
Anna N. Bukiya, Paul S. Blank, Avia Rosenhouse-Dantsker   +2 more
doaj   +1 more source

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

iScience, 2021
Summary: Mutations in the GNB1 gene, encoding the Gβ1 subunit of heterotrimeric G proteins, cause GNB1 Encephalopathy. Patients experience seizures, pointing to abnormal activity of ion channels or neurotransmitter receptors.
Haritha P. Reddy, Daniel Yakubovich, Tal Keren-Raifman, Galit Tabak, Vladimir A. Tsemakhovich, Maria H. Pedersen, Boris Shalomov, Sophie Colombo, David B. Goldstein, Jonathan A. Javitch, Amal K. Bera, Nathan Dascal   +11 more
doaj   +1 more source

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells

, 2009
Activation of G protein-gated inwardly-rectifying K(+) (GIRK or Kir3) channels by metabotropic gamma-aminobutyric acid (B) (GABA(B)) receptors is an essential signalling pathway controlling neuronal excitability and synaptic transmission in the brain. To
María José Cabañero, Martín Herranz, Ricardo, Fernández-Alacid, Laura, Ciruela, Francisco, Sánchez-Prieto, José, Carolina Aguado, José Colón, Francisco Ciruela, Colón, José, Sánchez-Prieto Borja, José, Luján, Rafael, Cabañero, María José, Gassman, Martin, Bettler, Bernhard, Shigemoto, Ryuichi, Martín, Ricardo, Ricardo Martín, Kevin Wickman, Rafael Luján, Watanabe, Masahiko, Masahiko Watanabe, Aguado, Carolina, Martin Gassmann, Ryuichi Shigemoto, Bernhard Bettler, Wickman, Kevin, José Sánchez‐Prieto, Laura Fernández‐Alacid, Gassmann, Martin   +28 more
core   +1 more source

Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics. [PDF]

Prog Neurobiol
Most neurons are influenced by multiple neuromodulatory inputs that converge on common effectors. Mechanisms that route these signals are key to selective neuromodulation but are poorly understood.
Luo H, Anderson A, Masuho I, Marron Fernandez de Velasco E, Birnbaumer L, Martemyanov KA, Wickman K.   +6 more
europepmc   +2 more sources

Cholesterol Regulation of Atrial GIRk Channels [PDF]

Biophysical Journal, 2014
In recent years, cholesterol emerged as a major regulator of ion channel function. The most common effect of cholesterol on ion channels is a decrease in channel activity. Here we focus on G-protein gated inwardly rectifying potassium (GIRK or Kir3) channels that play an important role in regulating membrane excitability in cardiac, neuronal and ...
Bukiya, Anna N., Osborn, Catherine V., Toth, Peter T., Kowalsky, Gregory, Baki, Lia, Oh, Myung J., Levitan, Irena, Rosenhouse-Dantsker, Avia   +7 more
openaire   +1 more source

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

eLife, 2014
In the hippocampus, the inhibitory neurotransmitter GABA shapes the activity of the output pyramidal neurons and plays important role in cognition.
Olga Ostrovskaya, Keqiang Xie, Ikuo Masuho, Ana Fajardo-Serrano, Rafael Lujan, Kevin Wickman, Kirill A Martemyanov   +6 more
doaj   +1 more source

Exploring the correlation between GIRK proteins and pain behavior in trigeminal neuralgia in mice

生物医学转化, 2023
Objective Trigeminal neuralgia is the most common maxillofacial pain syndrome, and its etiology has not been fully understood. In this paper, we focus on the role and expression of G protein-gated inwardly rectifying potassium channel (GIRK) protein in ...
Pan Xuqiang, Han Liang, Shi Tiejun
doaj   +1 more source