Results 21 to 30 of about 5,036 (195)
Neuron, 2002 G protein-activated potassium channels (GIRKs), monitored with the temporal and molecular resolution of electrophysiology, play a key role in the study of signal transduction. GIRKs are activated primarily by the G(beta)(gamma) subunits, but a paper by Peleg et al.
Kovoor, Abraham, Lester, Henry A.
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Pain relief but respiratory depression: Insights into the dark side of opioid overuse. [PDF]
J PhysiolThe Journal of Physiology, Volume 604, Issue 17, Page 7017-7018, 1 September 2026.
Zoccal DB.
europepmc +2 more sources
BRET-Based Approaches for Ion Channels: Emerging Applications and Future Directions. [PDF]
Arch Pharm (Weinheim)Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Kock N +6 more
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Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. [PDF]
PLoS ONE, 2011 Various antidepressants are commonly used for the treatment of depression and several other neuropsychiatric disorders. In addition to their primary effects on serotonergic or noradrenergic neurotransmitter systems, antidepressants have been shown to ...
Toru Kobayashi +2 more
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Advances in Targeting GIRK Channels in Disease
Trends in Pharmacological Sciences, 2021 G protein-gated inwardly rectifying potassium (GIRK) channels are essential regulators of cell excitability in the brain. While they are implicated in a variety of neurological diseases in both human and animal model studies, their therapeutic potential has been largely untapped.
Yulin, Zhao +3 more
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Redox Bridling of GIRK Channel Activity
Function, 2023 G protein-gated inwardly rectifying potassium (GIRK, Kir3.x) channels belong to the large family of inwardly rectifying potassium (Kir) channels expressed throughout the body. Activation and consequent opening of GIRK channels allow inward flow of potassium (K+) ions into the cell resulting in membrane potential hyperpolarization and decreased ...
Anna Boccaccio, Rocio K Finol-Urdaneta
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Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels
eLife, 2020 G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP2. Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP2 concentration.
Yiming Niu +3 more
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Receptor influences in GIRK current activation and desensitization [PDF]
, 2011 G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that sense extracellular signal and activate intracellular signaling pathways.
Park, Gyu
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Expression and relevance of the G protein-gated K+ channel in the mouse ventricle
Scientific Reports, 2018 The atrial G protein-gated inwardly rectifying K+ (GIRK) channel is a critical mediator of parasympathetic influence on cardiac physiology. Here, we probed the details and relevance of the GIRK channel in mouse ventricle.
Allison Anderson +8 more
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PLoS ONE, 2020 The G protein-gated inwardly rectifying K+ (GIRK) channels play important signaling roles in the central and peripheral nervous systems. However, the role of GIRK channel activation in pain signaling remains unknown mainly due to the lack of potent and ...
Masami Kimura +6 more
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