Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds [PDF]
BIO IntegrationDiabetes mellitus (DM) is a widespread metabolic disorder with profound effects on vital organs. Often referred to as a “systemic” or “multi-organ” disorder due to the impact on key organs, such as the kidneys, pancreas, eyes, and heart, DM is ...
Pallavi Pandey +3 more
doaj +2 more sources
Identification of the Potassium Channel Opener Site on Sulfonylurea Receptors [PDF]
Journal of Biological Chemistry, 1999 Diversity of sulfonylurea receptor (SUR) subunits underlies tissue specific pharmacology of K(ATP) channels, which represent critical regulators of electrical activity in numerous cells. Notably, the neuronal/pancreatic beta-cell receptor, SUR1, imparts high sensitivity to hypoglycemic sulfonylureas (SUs; e.g.
I, Uhde +4 more
openaire +3 more sources
Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues. [PDF]
Physiol Rep, 2015 International audienceATP-sensitive potassium channels (K-ATP channels) play a key role in adjusting the membrane potential to the metabolic state of cells.
Principalli MA +4 more
europepmc +2 more sources
Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]
, 1994 The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen +5 more
core +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The unusual stoichiometry of ADP activation of the KATP channel
Frontiers in Physiology, 2014 KATP channels, oligomers of 4 pore-forming Kir6.2 proteins and 4 sulfonylurea receptors (SUR), sense metabolism by monitoring both cytosolic ATP, which closes the channel by interacting with Kir6.2, and ADP, which opens it via SUR.
Eric eHosy, Michel eVivaudou
doaj +1 more source
β2-Adrenergic ion-channel coupled receptors as conformational motion detectors.
PLoS ONE, 2011 Ion Channel-Coupled Receptors (ICCRs) are artificial proteins comprised of a G protein-coupled receptor and a fused ion channel, engineered to couple channel gating to ligand binding.
Lydia N Caro +3 more
doaj +1 more source
Sulfonylurea derivatives and cancer, friend or foe? [PDF]
, 2019 Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at least in part, responsible for this effect.
Jalving, Mathilde +8 more
core +1 more source
Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations
Angewandte Chemie, EarlyView.Mechanochemistry is redefining metal catalysis by controlling catalyst formulation, speciation, and deployment. This Review shows how milling, LAG, RAM, and TSE enable rapid metal‐complex assembly, distinctive catalytic manifolds, and scalable synthesis beyond solution chemistry.
Sourav Behera +2 more
wiley +2 more sources
Molecular Medicine, 2018 Background Sulfonylureas (SUs) are widely prescribed for the treatment of type 2 diabetes (T2DM). Sulfonylurea receptors (SURs) are their main functional receptors. These receptors are also found in kidney, especially the tubular cells.
Rui Zhang +7 more
doaj +1 more source