The use of metformin, sulfonylurea compounds and insulin and the risk of hip fractures in diabetic patients: a systematic review and meta-analysis of observational studies. [PDF]
BMC Musculoskelet Disord, 2023 Background Hip fracture is a major health problem that occurs more often in the elderly, especially in diabetic patients. Some studies have been conducted regarding the effect of anti- diabetic drugs on fractures.
Bahardoust M +6 more
europepmc +2 more sources
Design, Synthesis, Activity and Docking Study of Sorafenib Analogs Bearing Sulfonylurea Unit
Molecules, 2015 Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures were confirmed by 1H-NMR, 13C-NMR, MS spectrum and elemental analysis.
Qidong Tang, Pengwu Zheng, Wufu Zhu
exaly +3 more sources
Anti-diabetic potential of Artemisia monosperma Delile extract related to anti-inflammatory, antioxidant, and wound-healing properties. [PDF]
Sci RepArtemisia monosperma Delile (Asteraceae) is traditionally used for gastrointestinal issues and diabetes. This study aimed to characterize its phenolic profile and evaluate the molecular basis for its antioxidant, anti-inflammatory, and antidiabetic ...
Atya HB +5 more
europepmc +2 more sources
Synergism of Synthetic Sulfonamides and Natural Antioxidants for the Management of Diabetes Mellitus Associated with Oxidative Stress. [PDF]
Curr Issues Mol BiolIn the context of expanding research on the development of compounds with multiple therapeutic actions, this study aims to consolidate findings from the last decade on new synthetic sulfonamide therapies for managing type 2 diabetes mellitus (T2DM ...
Dinu Iacob A +5 more
europepmc +2 more sources
Using the Scaffold of FDA-Approved Drugs with Trypanocidal Activity to Identify New Anti-<i>Trypanosoma cruzi</i> Agents: An In Silico and In Vitro Approach. [PDF]
MoleculesChagas disease affects millions of people worldwide, including those in Latin America. The only drugs available for its treatment are benznidazole and nifurtimox. However, these drugs present high toxicity and limited efficacy.
Vázquez-Jiménez LK +9 more
europepmc +2 more sources
Neonatal Diabetes Mellitus Due to KCNJ11 (KIR6.2) Mutation Successfully Treated with Sulfonylurea [PDF]
Neonatal Medicine, 2021 Neonatal diabetes mellitus (NDM) is a rare disease that occurs at less than 6 months of age and is presumably caused by a mutation in the gene that affects pancreatic beta-cell function. Approximately 80% of NDM cases reveal a known genetic mutation, and
Sehun Jang +5 more
doaj +1 more source
Molecules, 2022 Chlrosulfuron, a classical sulfonylurea herbicide that exhibits good safety for wheat but causes a certain degree of damage to subsequent corn in a wheat–corn rotation mode, has been suspended field application in China since 2014.
Lei Wu +5 more
doaj +1 more source
Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study [PDF]
Diabetes & Metabolism Journal, 2020 BackgroundThere is limited information regarding the optimal third-line therapy for managing type 2 diabetes mellitus (T2DM) that is inadequately controlled using dual combination therapy.
Jeong Mi Kim +12 more
doaj +1 more source
De novo HNF1A mutation of young maturity-onset diabetes 3 of a young girl—Case report
BMC Endocrine Disorders, 2023 Young maturity-onset diabetes of the young type3(MODY3) as a special type of diabetes, the probability of diagnosis is low. This article reports on a case and reviews the relevant knowledge of the disease. We report an 11-year-and-11-month-old girl whose
Haoran Peng, Jianbo Li, Zhang Wang
doaj +1 more source