Results 31 to 40 of about 3,697,166 (278)

Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines

open access: yesMolecules, 2017
A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation.
Ying Fu   +6 more
doaj   +1 more source

Novel Sulfonylurea Derivatives as Potential Antimicrobial Agents: Chemical Synthesis, Biological Evaluation, and Computational Study

open access: yesAntibiotics, 2023
Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide health threat and has already tormented humanity during its long history, creating an urgent need for the development of new classes of antibacterial agents.
Fan-Fei Meng   +8 more
doaj   +1 more source

Successful sulfonylurea treatment in a patient with permanent neonatal diabetes mellitus with a novel mutation [PDF]

open access: yesKorean Journal of Pediatrics, 2015
Permanent neonatal diabetes mellitus refers to diabetes that occurs before the age of 6 months and persists through life. It is a rare disorder affecting one in 0.2-0.5 million live births.
Sung Yeon Ahn, Gu-Hwan Kim, Han-Wook Yoo
doaj   +1 more source

In Silico Study of Mangostin Compounds and Its Derivatives as Inhibitors of α-Glucosidase Enzymes for Anti-Diabetic Studies

open access: yesBiology, 2022
Diabetes is a chronic disease with a high mortality rate worldwide and can cause other diseases such as kidney damage, narrowing of blood vessels, and heart disease. The concomitant use of drugs such as metformin, sulfonylurea, miglitol, and acarbose may
Ahmad Fariz Maulana   +3 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

Insulinoma Causing Hypoglycemia in a Patient with Type 2 Diabetes

open access: yesJournal of the Formosan Medical Association, 2007
Insulinoma in a patient with pre-existing diabetes is extremely rare. A 74-year-old woman with type 2 diabetes mellitus who had been treated with a sulfonylurea for 6 years began experiencing frequent episodes of hypoglycemia.
Wei-Yi Lei   +5 more
doaj   +1 more source

Synthesis and Characterization of Related Substances of Torasemide

open access: yesPharmaceutical Fronts, 2022
Torasemide, a pyridine-3-sulfonylurea derivative, is a high-efficiency loop diuretic. During the process development of torasemide, five process-related substances, which have been specified in the pharmacopeia, would be produced.
Jiong Chen   +3 more
doaj   +1 more source

A study of the action of hypoglycemia-producing biguanide and sulfonylurea compounds on oxidative phosphorylation.

open access: yesJournal of Biological Chemistry, 1962
The mechanism of the process of oxidative phosphorylation in the respiratory chain is still quite obscure. One approach to its study has involved an investigation of inhibitors of this phenomenon (l-3).
A. Falcone, R. L. Mao, E. Shrago
semanticscholar   +1 more source

SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION [PDF]

open access: yesAl-Azhar Journal of Pharmaceutical Sciences, 2013
In order to produce potent new leads for antidiabetic drugs, a new series of isoindoline-1,3-dione analogues bearing aryl sulfonylurea moieties were synthesized and screened for their antihyperglycemic activity.
Ibrahim Eissa
doaj   +1 more source

Methyl Caffeate Isolated from the Flowers of Prunus persica (L.) Batsch Enhances Glucose-Stimulated Insulin Secretion

open access: yesBiomolecules, 2021
Phenolic compounds from natural products are considered effective enhancers of insulin secretion to prevent and treat type 2 diabetes (T2DM). The flowers of Prunus persica (L.) Batsch also contain many phenolic compounds.
Dahae Lee   +7 more
doaj   +1 more source

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