Results 31 to 40 of about 5,580 (266)

Insulinoma Causing Hypoglycemia in a Patient with Type 2 Diabetes

Journal of the Formosan Medical Association, 2007
Insulinoma in a patient with pre-existing diabetes is extremely rare. A 74-year-old woman with type 2 diabetes mellitus who had been treated with a sulfonylurea for 6 years began experiencing frequent episodes of hypoglycemia.
Wei-Yi Lei, Tsang-En Wang, Tien-Ling Chen, Wen-Hsiung Chang, Tsen-Long Yang, Cheng-Yi Wang   +5 more
doaj   +1 more source

SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2013
In order to produce potent new leads for antidiabetic drugs, a new series of isoindoline-1,3-dione analogues bearing aryl sulfonylurea moieties were synthesized and screened for their antihyperglycemic activity.
Ibrahim Eissa
doaj   +1 more source

Methyl Caffeate Isolated from the Flowers of Prunus persica (L.) Batsch Enhances Glucose-Stimulated Insulin Secretion

Biomolecules, 2021
Phenolic compounds from natural products are considered effective enhancers of insulin secretion to prevent and treat type 2 diabetes (T2DM). The flowers of Prunus persica (L.) Batsch also contain many phenolic compounds.
Dahae Lee, Yutong Qi, Ranhee Kim, Jungbin Song, Hocheol Kim, Hyun Young Kim, Dae Sik Jang, Ki Sung Kang   +7 more
doaj   +1 more source

Tetracarpidium conophorum seed extract reduces intestinal absorption, and increases cellular trapping of glucose

Bulletin of the National Research Centre, 2021
Background Tetracarpidium conophorum is one of the numerous folklore medicinal plants for managing diabetes but the mode of action and bioactive compounds responsible for the antihyperglycemic property are missing in literatures.
Bamidele Stephen Ajilore, Olubukola Sinbad Olorunnisola, Abiodun Olusoji Owoade   +2 more
doaj   +1 more source

Structure-activity relationships for a new family of sulfonylurea herbicides

, 2005
Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) catalyzes the first common step in branched-chain amino acid biosynthesis. The enzyme is inhibited by several chemical classes of compounds and this inhibition is the basis of action of the sulfonylurea and ...
Lee, Yu-Ting, Ma, Zheng-Ming, Wang, Bao-Lei, Jiang, Lin, Li, Zheng-Ming, Guddat, Luke W., Pang, Siew Siew, Duggleby, Ronald G., Wang, Jian-Guo   +8 more
core   +1 more source

Optical control of insulin release using a photoswitchable sulfonylurea [PDF]

, 2014
Sulfonylureas are widely prescribed for the treatment of type 2 diabetes mellitus (T2DM). Through their actions on ATP-sensitive potassium (KATP) channels, sulfonylureas boost insulin release from the pancreatic beta cell mass to restore glucose ...
Trapp, S, Trauner, D, Rutter, GA, Schönberger, M, Marchetti, P, Broichhagen, J, Shapiro, AMJ, Shapiro, AM, Cork, SC, Frank, JA, Hodson, DJ, Bugliani, M   +11 more
core   +3 more sources

Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1

Pharmaceuticals, 2020
Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, selectivity and potency of first ...
Sonam Roy, Amarjyoti Das Mahapatra, Taj Mohammad, Preeti Gupta, Mohamed F. Alajmi, Afzal Hussain, Md. Tabish Rehman, Bhaskar Datta, Md. Imtaiyaz Hassan   +8 more
doaj   +1 more source

Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones [PDF]

Diabetes & Metabolism Journal, 2011
BackgroundSulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PPARγ ...
Kyeong Won Lee, Yun Hyi Ku, Min Kim, Byung Yong Ahn, Sung Soo Chung, Kyong Soo Park   +5 more
doaj   +1 more source

Characterization of sulfonylurea receptors in isolated human pancreatic islets

, 1998
Current information on pancreatic islet sulfonylurea receptors has been obtained with laboratory animal pancreatic beta cells or stable beta-cell lines.
GIANNACCINI, GINO, MARCHETTI, PIERO, MARTINI, CLAUDIA, DEL GUERRA S., LUPI R., NAVALESI R., BETTI, LAURA, TRINCAVELLI, MARIA LETIZIA, LUCACCHINI, ANTONIO   +8 more
core   +1 more source

Weight change and risk of cardiovascular disease among adults with type 2 diabetes: more than 14 years of follow-up in the Tehran Lipid and Glucose Study

Cardiovascular Diabetology, 2021
Background To examine the impact of weight change on incident cardiovascular disease and coronary heart disease (CVD/CHD) among an Iranian population with type 2 diabetes mellitus (T2DM).
Seyyed Saeed Moazzeni, Reyhane Hizomi Arani, Niloofar Deravi, Mitra Hasheminia, Davood Khalili, Fereidoun Azizi, Farzad Hadaegh   +6 more
doaj   +1 more source