The use of metformin, sulfonylurea compounds and insulin and the risk of hip fractures in diabetic patients: a systematic review and meta-analysis of observational studies [PDF]
BMC Musculoskeletal Disorders, 2023 Background Hip fracture is a major health problem that occurs more often in the elderly, especially in diabetic patients. Some studies have been conducted regarding the effect of anti- diabetic drugs on fractures.
Mansour Bahardoust +6 more
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Using the Scaffold of FDA-Approved Drugs with Trypanocidal Activity to Identify New Anti-Trypanosoma cruzi Agents: An In Silico and In Vitro Approach [PDF]
MoleculesChagas disease affects millions of people worldwide, including those in Latin America. The only drugs available for its treatment are benznidazole and nifurtimox. However, these drugs present high toxicity and limited efficacy.
Lenci K. Vázquez-Jiménez +9 more
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Synergism of Synthetic Sulfonamides and Natural Antioxidants for the Management of Diabetes Mellitus Associated with Oxidative Stress [PDF]
Current Issues in Molecular BiologyIn the context of expanding research on the development of compounds with multiple therapeutic actions, this study aims to consolidate findings from the last decade on new synthetic sulfonamide therapies for managing type 2 diabetes mellitus (T2DM ...
Ancuța Dinu (Iacob) +5 more
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Synthesis of sulfonylurea derivatives and their α-glucosidase inhibitory activity
Vietnam Journal of Science, Technology and Engineering, 2022 The paper describes the preparation of new sulfonylurea derivatives from sulfonyl carbamate 6 with amino derivatives. The process for synthesis of the key compound 6 included three steps starting from compound 6-chloronicotinic acid 1, which are readily
Thi Thoi Bui +2 more
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Alkaline Soil Degradation and Crop Safety of 5-Substituted Chlorsulfuron Derivatives
Molecules, 2022 Sulfonylurea herbicides can lead to serious weed resistance due to their long degradation times and large-scale applications. This is especially true for chlorsulfuron, a widely used acetolactate synthase inhibitor used around the world.
Lei Wu +5 more
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Antibiotics, 2023 Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide health threat and has already tormented humanity during its long history, creating an urgent need for the development of new classes of antibacterial agents.
Fan-Fei Meng +8 more
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Biology, 2022 Diabetes is a chronic disease with a high mortality rate worldwide and can cause other diseases such as kidney damage, narrowing of blood vessels, and heart disease. The concomitant use of drugs such as metformin, sulfonylurea, miglitol, and acarbose may
Ahmad Fariz Maulana +3 more
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Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]
, 1994 Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan +29 more
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Successful sulfonylurea treatment in a patient with permanent neonatal diabetes mellitus with a novel mutation [PDF]
Korean Journal of Pediatrics, 2015 Permanent neonatal diabetes mellitus refers to diabetes that occurs before the age of 6 months and persists through life. It is a rare disorder affecting one in 0.2-0.5 million live births.
Sung Yeon Ahn, Gu-Hwan Kim, Han-Wook Yoo
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Synthesis and Characterization of Related Substances of Torasemide
Pharmaceutical Fronts, 2022 Torasemide, a pyridine-3-sulfonylurea derivative, is a high-efficiency loop diuretic. During the process development of torasemide, five process-related substances, which have been specified in the pharmacopeia, would be produced.
Jiong Chen +3 more
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