Results 11 to 20 of about 5,580 (266)

Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines

Molecules, 2017
A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation.
Ying Fu, Jing-Yi Wang, Dong Zhang, Yu-Feng Chen, Shuang Gao, Li-Xia Zhao, Fei Ye   +6 more
doaj   +3 more sources

Assessing the environmental risks of sulfonylurea pollutants: Insights into the risk priority and structure-toxicity relationships

Ecotoxicology and Environmental Safety
Sulfonylureas are widely used herbicides globally; however, the health risks associated with exposure to these compounds are poorly understood. This study used fuzzy clustering to categorize 44 sulfonylurea compounds into three risk priority levels (I ...
Zhi-Cong He, Tao Zhang, Xin-Fang Lu, Rui Li, Wei Peng, Fei Ding   +5 more
doaj   +2 more sources

Treatment of chemical diabetes mellitus with sulfonylurea compounds [PDF]

Metabolism, 1973
EFORE DISCUSSING the use of sulfonylurea compounds in the treatment of chemical diabetes, we must ask ourselves whether there is any evidence to indicate that mild carbohydrate intolerance may be harmful. Although this is a controversial question, there is some evidence that this may be true.
Fajans, Stefan S.
openaire   +4 more sources

Novel Sulfonylurea Derivatives as Potential Antimicrobial Agents: Chemical Synthesis, Biological Evaluation, and Computational Study

Antibiotics, 2023
Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide health threat and has already tormented humanity during its long history, creating an urgent need for the development of new classes of antibacterial agents.
Fan-Fei Meng, Ming-Hao Shang, Wei Wei, Zhen-Wu Yu, Jun-Lian Liu, Zheng-Ming Li, Zhong-Wen Wang, Jian-Guo Wang, Huan-Qin Dai   +8 more
doaj   +2 more sources

Screening of Some Sulfonamide and Sulfonylurea Derivatives as Anti-Alzheimer’s Agents Targeting BACE1 and PPARγ

Journal of Chemistry, 2020
In the last few decades, Alzheimer’s disease (AD) has emerged as a serious global problem, and it has been considered as the most common type of dementia.
Ning Li, Yan Wang, Wensheng Li, Haiyan Li, Liu Yang, Jun Wang, Hazem A. Mahdy, Ahmed B. M. Mehany, Dareen A. Jaiash, Eman Y. Santali, Ibrahim H. Eissa   +10 more
doaj   +2 more sources

Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitors

Results in Chemistry
Herein, we describe the design, synthesis and biological evaluation of a series of novel non-nucleotide sulfonylurea and sulfonylthiourea based small molecule inhibitors of h-ENPP1, h-ENPP3 and e5′NT. Among the tested compounds, 3b inhibited h-ENPP1 with
Abdullah Yahya Abdullah Alzahrani, Abdul Hameed, Abdul Rehman Khan, Julie Pelletier, Jean Sévigny, Jamshed Iqbal   +5 more
doaj   +2 more sources

Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents

Molecules, 2015
Sulphonylurea compounds have versatile activities such as antidiabetic, diuretic, herbicide, oncolytic, antimalarial, antifungal and anticancer. The present study describes the design, synthesis and in vivo testing of novel glycosylated aryl sulfonylurea
Ghadeer A. R. Y. Suaifan, Mayadah B. Shehadeh, Rula M. Darwish, Hebah Al-Ijel, Vincenzo Abbate   +4 more
doaj   +2 more sources

Synthesis of sulfonylurea derivatives and their α-glucosidase inhibitory activity

Vietnam Journal of Science, Technology and Engineering, 2022
The paper describes the preparation of new sulfonylurea derivatives from sulfonyl carbamate 6 with amino derivatives. The process for synthesis of the key compound 6 included three steps starting from compound 6-chloronicotinic acid 1, which are readily
Thi Thoi Bui, Dai Quang Ngo, Van Loc Tran   +2 more
doaj   +1 more source

Bioequivalence assessment of the two brands of glimepiride tablets [PDF]

Vojnosanitetski Pregled, 2006
Background/Aim. Glimepiride, as an antidiabetic from the group of sulfonylurea, is administered perorally in the treatment of diabetes mellitus. The aim of this study was to compare pharmacokinetic profiles and relative bioavailabilities of the two oral ...
Jovanović Dušan, Stojšić Dragan, Zlatković Milica, Jović-Stošić Jasmina, Jovanović Miodrag   +4 more
doaj   +1 more source

Cardiovascular Outcomes Comparison of Dipeptidyl Peptidase-4 Inhibitors versus Sulfonylurea as Add-on Therapy for Type 2 Diabetes Mellitus: a Meta-Analysis

Journal of Lipid and Atherosclerosis, 2021
Objective Recent studies have raised concern about the cardiovascular safety of dipeptidyl peptidase-4 (DPP4) inhibitors. We performed a systematic review through meta-analysis to compare cardiovascular outcomes of sulfonylurea (SU) versus DPP4 ...
Won Kyeong Jeon, Jeehoon Kang, Hyo-Soo Kim, Kyung Woo Park   +3 more
doaj   +1 more source