Results 1 to 10 of about 20,150 (206)
Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants [PDF]
Clinical and Translational ScienceEfavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using ...
Jason D. Kim +4 more
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Selection of an Optimal Metabolic Model for Accurately Predicting the Hepatic Clearance of Albumin-Binding-Sensitive Drugs [PDF]
PharmaceuticalsBackground/Objectives: Hepatic clearance is important in determining clinical drug administration strategies. Achieving accurate hepatic clearance predictions through in vitro-to-in vivo extrapolation (IVIVE) relies on appropriate model selection, which ...
Ren-Jong Liang +7 more
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Live Cell Monitoring of Phosphodiesterase Inhibition by Sulfonylurea Drugs [PDF]
BiomoleculesSulfonylureas (SUs) are a class of antidiabetic drugs widely used in the management of diabetes mellitus type 2. They promote insulin secretion by inhibiting the ATP-sensitive potassium channel in pancreatic β-cells.
Filip Berisha +2 more
doaj +2 more sources
Development and Validation of a Quantitative LC-MS/MS Method for Measuring CYP4V2 Enzyme Activity via 12-Hydroxylauric Acid in rAAV-hCYP4V2 Gene Therapy Products [PDF]
MoleculesBietti crystalline dystrophy (BCD) is a hereditary retinal disease caused by loss-of-function mutations in the CYP4V2 gene. Gene replacement therapy using rAAV-hCYP4V2 represents a promising therapeutic strategy, requiring robust bioassays for product ...
Ge Ren +8 more
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Frontiers in Pharmacology, 2021 Warfarin is a widely prescribed anticoagulant but the doses required to attain the optimum therapeutic effect exhibit dramatic inter-individual variability. Pharmacogenomics-guided warfarin dosing has been recommended to improve safety and effectiveness.
Xiao-Yang Zhou +14 more
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Solubility Enhancement of Antidiabetic Drugs Using a Co‐Crystallization Approach
ChemistryOpen, 2021 The co‐crystallization approach has been used to enhance specific desirable properties of active pharmaceutical ingredients (APIs) such as solubility, dissolution rate, and stability.
Dr. Eustina Batisai
doaj +1 more source
Journal of Advanced Research, 2022 Introduction: Pharmacokinetic variability in disease state is common in clinical practice, but its underlying mechanism remains unclear. Recently, gut microbiota has been considered to be pharmacokinetically equivalent to the host liver.
Jing Guo +9 more
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Frontiers in Pharmacology, 2021 Poziotinib is an orally active, irreversible, pan-HER tyrosine kinase inhibitor used to treat non-small cell lung cancer, breast cancer, and gastric cancer.
Jinhui Wang +10 more
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ATP-gated potassium channels contribute to ketogenic diet-mediated analgesia in mice
Neurobiology of Pain, 2023 Chronic pain is a substantial health burden and options for treating chronic pain remain minimally effective. Ketogenic diets are emerging as well-tolerated, effective therapeutic strategies in preclinical models of chronic pain, especially diabetic ...
Jonathan D. Enders +7 more
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Journal of Analytical Methods in Chemistry, 2022 Linderane (LDR), the main active and distinctive component of L. aggregate, is a mechanism-based inactivator of CYP2C9 in vitro, indicating the occurrence of herb-drug interactions.
Tingting Zhang +4 more
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