Results 11 to 20 of about 20,169 (222)

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms. [PDF]

J Neuroendocrinol
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Lavoie O, Turmel A, Khouma A, Minbashi Moeini M, Liu C, Michael NJ, Caron A.   +6 more
europepmc   +2 more sources

Maternal-to-Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines. [PDF]

Clin Pharmacol Ther
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Richardson K, Kiptoo J, Mpora Odongkara B, Ojara FW, Waitt C.   +4 more
europepmc   +2 more sources

Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats

BMC Endocrine Disorders, 2005
Background Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia. Increased oxidative stress and decreased antioxidant levels are the leading cause of diabetes and diabetic complications.
Vardhan Vishnu A, Kilari Eswar K, Sreemantula Satyanarayana, Jaladi Rajasekhar   +3 more
doaj   +1 more source

Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres [PDF]

, 1989
The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as K+ channel openers, on the electrical activity of human skeletal muscle.
Grafe, Peter, Lehmann-Horn, Frank, Spuler, A.   +2 more
core   +1 more source

Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo

Frontiers in Pharmacology, 2020
BackgroundVonoprazan fumarate is a potassium-competitive acid blocker that was developed as a novel acid-suppressing drug for multiple indications. As a potential alternative to proton-pump inhibitors, the determination of the drug-drug interactions is ...
Yiran Wang, Changxiong Wang, Shuanghu Wang, Quan Zhou, Dapeng Dai, Jihua Shi, Xue Xu, Qingfeng Luo   +7 more
doaj   +1 more source

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Altan, Aoki, Avruch, Bak, Begum, Brown, Caren, Clancy, Cooper, Cushman, Daniels, Davidson, Farese, Feldman, Feldman, Gavin, Geisen, Gould, Guinovart, Hirshman, Honnor, Jacobs, Jacobs, Jacobs, James, James, Karnieli, Kirsch, Klip, Kolterman, Kono, Lane, Larner, Lawrence, Lawson, Lebovitz, Leichter, Maloff, Mandarino, Misek, Moody, Müller, Müller, Müller, Müller, Müller, Okuno, Oron, Osegawa, Panten, Popov, Putnam, Reusch, Rogers, Roskoski, Saltiel, Saltiel, Saltiel, Simonson, Smith, Solomon, Standing, Suissa, Suzuki, Tordjman, Towbin, Van Putten, Vila, Villalba, Wang, Wang, Wieland, Wray, Yalow, Zinman, Zuber   +75 more
core   +1 more source

Crystal structure of 4-bromo-N-(propylcarbamoyl)benzenesulfonamide

Acta Crystallographica Section E: Crystallographic Communications, 2022
The title compound, C10H13BrN2O3S, 1, contains a sulfonyl urea moiety, which possesses potential therapeutic functions (e.g., anti-diabetic and herbicidal).
Mustafa Bookwala, Saloni Patel, Patrick T. Flaherty, Peter L. D. Wildfong   +3 more
doaj   +1 more source

The glycemic elemental profile of trichosanthes dioica: a LIBS-based study [PDF]

, 2010
The scientific evaluation of the antidiabetic efficacy of aqueous extract of Trichosanthes dioica fruits on streptozotocin-induced diabetic rats is being presented. The graded doses of the extract, viz., 500, 750, 1,000, and 1,250 mg/kg body weight (bw),
Bicanic, D.D., Chatterji, S., Rai, N.K., Rai, P.K., Watal, G.   +4 more
core   +2 more sources

Xiao chai hu tang for liver diseases: A literature review

World Journal of Traditional Chinese Medicine, 2017
The objective of this study is to summarize the pharmacological effects and the mechanisms of action of Xiao Chai Hu Tang (XCHT, Minor Bupleurum Decoction) on liver diseases, so as to give relevant researchers a valuable insight and benefit patients with
Yi Wang, Li Li, Yan-Mei Cheng, Sheng-Liang Zhu   +3 more
doaj   +1 more source

Within-Sulfonylurea-Class Evaluation of Time to Intensification with Insulin (ZODIAC-43). [PDF]

PLoS ONE, 2016
Previous studies have shown that many within-class differences exist between sulfonylureas (SUs), however, whether differences exist regarding the time it takes between initiating an SU and the need to intensify treatment with insulin is unclear. The aim
Dennis Schrijnders, Laura C Hartog, Nanne Kleefstra, Klaas H Groenier, Gijs W D Landman, Henk J G Bilo   +5 more
doaj   +1 more source