Host-Guest Chemistry of Tolbutamide
Molecules, 2006 The molecular recognition features of tolbutamide with four synthetic hosts have been studied by means of NMR titrations, NOESY experiments and Monte Carlo (MC) conformational search.
Rosa M. Claramunt +2 more
doaj +2 more sources
Effect of Temperature on Tolbutamide Binding to Glycated Serum Albumin [PDF]
Molecules, 2017 Glycation process occurs in protein and becomes more pronounced in diabetes when an increased amount of reducing sugar is present in bloodstream. Glycation of protein may cause conformational changes resulting in the alterations of its binding properties
Agnieszka Szkudlarek +4 more
doaj +2 more sources
High-Throughput Multi-Capillary Electrophoresis. [PDF]
ElectrophoresisMulti‐capillary electrophoresis enables high‐throughput pharmaceutical analysis through simultaneous multi‐capillary operation, achieving a five‐fold reduction in run time per sample with improved sensitivity and linearity. Method transfer from single‐capillary systems is straightforward, supporting rapid and accurate quantification across diverse ...
Drewes J +6 more
europepmc +2 more sources
The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin. [PDF]
Clin Pharmacol TherDicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Shaul C +5 more
europepmc +2 more sources
Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb-Drug Interaction Investigation. [PDF]
Biopharm Drug DisposPharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Gajula SNR +4 more
europepmc +2 more sources
Applications of human microdosing with accelerator mass spectrometry: assessment of ability to predict drug-drug interactions and determine the pharmacokinetics of enantiomers [PDF]
, 2012 In this thesis, new applications of microdosing were explored in two clinical trials. Methods were developed for the separation and quantification of 14C-labelled analytes in human plasma using two-dimensional HPLC and accelerator mass ...
Croft, M L
core +6 more sources
Genetic and Clinical Determinants of Variation in Drug Response in Type 2 Diabetes: Insights From the Scottish and UK Biobank Cohorts. [PDF]
Diabetes Obes MetabABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
Garg S +4 more
europepmc +2 more sources
Journal of Analytical Methods in Chemistry, 2022 Linderane (LDR), the main active and distinctive component of L. aggregate, is a mechanism-based inactivator of CYP2C9 in vitro, indicating the occurrence of herb-drug interactions.
Tingting Zhang +4 more
doaj +1 more source
Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]
, 1994 The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen +5 more
core +1 more source