Results 41 to 50 of about 13,288 (170)
KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons
Frontiers in Cellular Neuroscience, 2014 Medial temporal lobe structures are essential for memory formation which is associated with coherent network oscillations. During ontogenesis, these highly organized patterns develop from distinct, less synchronized forms of network activity.
Maria S. Lemak +6 more
doaj +1 more source
BK channels reveal novel phosphate sensitivity in SNr neurons. [PDF]
PLoS ONE, 2012 Whether large conductance Ca(2+)-activated potassium (BK) channels are present in the substantia nigra pars reticulata (SNr) is a matter of debate. Using the patch-clamp technique, we examined the functional expression of BK channels in neurons of the ...
Juan Juan Ji +9 more
doaj +1 more source
Scientific Reports, 2021 Teucrium yemense, a medicinal plant commonly grown in Saudi Arabia and Yemen, is traditionally used to treat infections, kidney diseases, rheumatism, and diabetes.
Mohammad Nur-e-Alam +8 more
doaj +1 more source
Cisapride induced hypoglycemia via the KCNH6 potassium channel
Frontiers in Endocrinology, 2022 Mutations in KCNH6 has been proved to cause hypoinsulinemia and diabetes in human and mice. Cisapride is a stomach–intestinal motility drug used to treat gastrointestinal dysfunction.
Jing Lu +7 more
doaj +1 more source
eFood, Volume 7, Issue 3, June 2026.Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy +7 more
wiley +1 more source
Dose Dependent Effect of Sulfamethoxazole on Inhibiting K Channel of Mouse Pancreatic β Cell
Dose-Response, 2023 Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin ...
Hiroshi Ogata +7 more
doaj +1 more source
Cardiovascular Diabetology, 2010 Background The optimum oral pharmacological treatment of diabetes mellitus to reduce cardiovascular disease and mortality following myocardial infarction has not been established.
Jørgensen Casper H +9 more
doaj +1 more source
Post-hypoxic recovery of respiratory rhythm generation is gender dependent. [PDF]
PLoS ONE, 2013 The preBötzinger complex (preBötC) is a critical neuronal network for the generation of breathing. Lesioning the preBötC abolishes respiration, while when isolated in vitro, the preBötC continues to generate respiratory rhythmic activity.
Alfredo J Garcia +3 more
doaj +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Frontiers in Pharmacology, 2018 Since the implementation of several legislations to improve pediatric drug research, more pediatric clinical trials are being performed. In order to optimize these pediatric trials, adequate preclinical data are necessary, which are usually obtained by ...
Joske Millecam +10 more
doaj +1 more source