Results 41 to 50 of about 15,995 (210)

Synthesis and characterization of tolbutamide–molybdenum complex by thermal, spectral and X-ray studies

Journal of Saudi Chemical Society, 2010
Synthesis and characterization of molybdenum complex with tolbutamide (an oral antidiabetic drug) have been studied. The conductometric titration using monovariation method indicates that complex is non-ionic and of L2M type.
S. A. Iqbal, George Jacob, I. Zaafarany
doaj   +1 more source

Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs

Frontiers in Pharmacology, 2022
Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, and time-consuming procedures, pharmacokinetic profiling is still irreplaceable in ...
Yawen Yuan, Yawen Yuan, Qingfeng He, Shunguo Zhang, Min Li, Zhijia Tang, Xiao Zhu, Zheng Jiao, Weimin Cai, Xiaoqiang Xiang   +9 more
doaj   +1 more source

An antioxidant activity of Cinnamonum tamala improves histopathological alterations and biochemical parameters in alloxan induced diabetic rats

Asian Journal of Medical Sciences, 2019
Background: Diabetic mellitus is a multifactorial disorder associated with its devastating consequences has assumed epidemic proportion. Diabetes mellitus (DM) is a global health problem and the incidence of DM is increasing at alarming rate all over the
Mamata Laxmikant Pochhi
doaj   +1 more source

High‐Throughput Multi‐Capillary Electrophoresis

ELECTROPHORESIS, EarlyView.
Multi‐capillary electrophoresis enables high‐throughput pharmaceutical analysis through simultaneous multi‐capillary operation, achieving a five‐fold reduction in run time per sample with improved sensitivity and linearity. Method transfer from single‐capillary systems is straightforward, supporting rapid and accurate quantification across diverse ...
Jana Drewes, Sarah Meyer, Isobel Roberts, Cleo Fanny, Philip A. Doble, Dayanne Mozaner Bordin, Janice I. McCauley   +6 more
wiley   +1 more source

Cytochrome P-450 2C9 phenotyping using low-dose tolbutamide

, 2004
Objectives. The hypoglycaemic drug tolbutamide is used for assessment of CYP2C9 activity in vivo. However, therapeutically active doses of 500 mg bear the risk of hypoglycaemia, and a tolbutamide-derived parameter based on a single plasma or urine ...
Jabrane, W., Jetter, A., Kirchheiner, Julia, Brockmoeller, Juergen, Kasel, D., Hering, U., Lazar, A., Jakob, V., Skott, A., Rodamer, M., Sorgel, F., Tomalik-Scharte, D., Fuhr, Uwe, Kinzig-Schippers, M., Walchner-Bonjean, M.   +14 more
core   +1 more source

The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats

Integrative Medicine Research, 2017
Background: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and ...
Manodeep Chakraborty, Mohammed Gulzar Ahmed, Ananya Bhattacharjee   +2 more
doaj   +1 more source

Natural products embedded crown ethers as potent insulin secretory agents

Pakistan Journal of Pharmaceutical Sciences, 2021
Natural products embedded crown ethers were prepared by utilizing bioactive natural products including chrysin, tetrahydroisoquinoline (THIQ), and biochanin-A.
Nuzhat Arshad, Abdul Hameed, Jamshed Hashim, Tahseen Iqbal, Iqra Munir, Syed Abid Ali, Maha Sharif, Deedar Ali, Shumaila Javed, Rahman M Hafizur   +9 more
doaj   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Population-based modeling to demonstrate extrapancreatic effects of tolbutamide

, 1998
Tolbutamide is used increasingly as an investigative tool in in vivo studies of the physiology of glucose tolerance. Its hypoglycemic effect in nondiabetic subjects is widely variable, reflecting possible variability in its pharmacokinetics, an ...
G. T. Tucker, S. R. Peacey, A. Rostami-Hodjegan, E. George, S. R. Heller   +4 more
core   +1 more source

KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons

Frontiers in Cellular Neuroscience, 2014
Medial temporal lobe structures are essential for memory formation which is associated with coherent network oscillations. During ontogenesis, these highly organized patterns develop from distinct, less synchronized forms of network activity.
Maria S. Lemak, Maria S. Lemak, Oksana eVoloshanenko, Andreas eDraguhn, Andreas eDraguhn, Alexei V. Egorov, Alexei V. Egorov   +6 more
doaj   +1 more source